Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Takao Shishido"'
Autor:
Keita Fukao, Takeshi Noshi, Shinya Shano, Kaoru Baba, Kenji Sato, Masashi Sakuramoto, Naohisa Kitade, Hideki Tanioka, Shinji Kusakabe, Takao Shishido
Publikováno v:
Viruses, Vol 15, Iss 11, p 2264 (2023)
Influenza remains a worldwide health concern. Antiviral drugs are considered as one of the useful options for its prevention as a complementary measure to vaccination. Baloxavir acid selectively inhibits the cap-dependent endonuclease of influenza vi
Externí odkaz:
https://doaj.org/article/3d0f8d5ec5c64235aeaaa042d9b2f1f0
Autor:
Harry L. Stannard, Edin J. Mifsud, Steffen Wildum, Sook Kwan Brown, Paulina Koszalka, Takao Shishido, Satoshi Kojima, Shinya Omoto, Keiko Baba, Klaus Kuhlbusch, Aeron C. Hurt, Ian G. Barr
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
A clinical influenza isolate with dual antiviral resistant mutations displays a moderate loss of viral fitness in ferrets compared to wild-type virus, suggesting widespread community transmission of this dual mutant is unlikely.
Externí odkaz:
https://doaj.org/article/450f13fea2434b3a881cfa9fa16c3fa5
Autor:
Keita Fukao, Haruaki Nobori, Takayuki Kuroda, Kaoru Baba, Kazumi Matsumoto, Yukari Tanaka, Yuki Tachibana, Teruhisa Kato, Takao Shishido
Publikováno v:
Viruses, Vol 15, Iss 10, p 2052 (2023)
The small-molecule antiviral drug ensitrelvir targets the 3C-like protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study evaluated its inhibitory effect on viral replication in a delayed-treatment mouse model and investi
Externí odkaz:
https://doaj.org/article/d5518e9b9d154508a307272554b1b36c
Autor:
Takayuki Kuroda, Keita Fukao, Shinpei Yoshida, Ryoko Oka, Kaoru Baba, Yoshinori Ando, Keiichi Taniguchi, Takeshi Noshi, Takao Shishido
Publikováno v:
Viruses, Vol 15, Iss 5, p 1154 (2023)
Although the prevalence of polymerase acidic (PA)/I38T strains of influenza virus with reduced susceptibility to baloxavir acid is low, there is a possibility of emergence under selective pressure. Furthermore, the virus may be transmitted between hu
Externí odkaz:
https://doaj.org/article/10d935ba69ee4c45b0ca89d03f84d577
Autor:
Leo Y Lee, Jie Zhou, Paulina Koszalka, Rebecca Frise, Rubaiyea Farrukee, Keiko Baba, Shahjahan Miah, Takao Shishido, Monica Galiano, Takashi Hashimoto, Shinya Omoto, Takeki Uehara, Edin J Mifsud, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Steffen Wildum, Wendy S Barclay, Aeron C Hurt
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009527 (2021)
Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patients. Treatment-emergent viruses with reduced susceptibility to baloxavir have been detected in clinical trials, but the li
Externí odkaz:
https://doaj.org/article/6a080755b2e74791b2fa666dd6d94232
Autor:
Keiichi Taniguchi, Yoshinori Ando, Masanori Kobayashi, Shinsuke Toba, Haruaki Nobori, Takao Sanaki, Takeshi Noshi, Makoto Kawai, Ryu Yoshida, Akihiko Sato, Takao Shishido, Akira Naito, Keita Matsuno, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida
Publikováno v:
Viruses, Vol 14, Iss 1, p 111 (2022)
Human infections caused by the H5 highly pathogenic avian influenza virus (HPAIV) sporadically threaten public health. The susceptibility of HPAIVs to baloxavir acid (BXA), a new class of inhibitors for the influenza virus cap-dependent endonuclease,
Externí odkaz:
https://doaj.org/article/2992f7db62694e5e81d10f333c956cd5
Autor:
Leo Yi Yang Lee, Jie Zhou, Rebecca Frise, Daniel H Goldhill, Paulina Koszalka, Edin J Mifsud, Kaoru Baba, Takahiro Noda, Yoshinori Ando, Kenji Sato, Aoe-Ishikawa Yuki, Takao Shishido, Takeki Uehara, Steffen Wildum, Elke Zwanziger, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Aeron C Hurt, Wendy S Barclay
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008395 (2020)
Influenza viruses cause seasonal outbreaks and pose a continuous pandemic threat. Although vaccines are available for influenza control, their efficacy varies each season and a vaccine for a novel pandemic virus manufactured using current technology
Externí odkaz:
https://doaj.org/article/61b97708882143f882083c1fe0a052d6
Autor:
Keita Fukao, Yoshinori Ando, Takeshi Noshi, Mitsutaka Kitano, Takahiro Noda, Makoto Kawai, Ryu Yoshida, Akihiko Sato, Takao Shishido, Akira Naito
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217307 (2019)
Baloxavir marboxil (BXM) is an orally available small molecule inhibitor of cap-dependent endonuclease (CEN), an essential enzyme in the initiation of mRNA synthesis of influenza viruses. In the present study, we evaluated the efficacy of BXM against
Externí odkaz:
https://doaj.org/article/8b11bc6137a14a9da7d69f51f9499fe9
Autor:
Takayuki Kuroda, Haruaki Nobori, Keita Fukao, Kaoru Baba, Kazumi Matsumoto, Shinpei Yoshida, Yukari Tanaka, Ryosuke Watari, Ryoko Oka, Yasuyuki Kasai, Kae Inoue, Sho Kawashima, Alice Shimba, Yoko Hayasaki-Kajiwara, Miki Tanimura, Qianhui Zhang, Yuki Tachibana, Teruhisa Kato, Takao Shishido
Publikováno v:
Journal of Antimicrobial Chemotherapy. 78:946-952
Objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become established in the human population, making the need to develop safe and effective treatments critical. We have developed the small-molecule antiviral ensitrelvir, whi
Publikováno v:
YAKUGAKU ZASSHI. 142:691-696
Overcoming serious infectious diseases such as malaria, tuberculosis, and other neglected tropical diseases (NTDs) that threaten human life around the world is an important issue in global health. Most of these diseases are concentrated in developing