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Botulinum toxin injections for Japanese patients with urinary incontinence caused by neurogenic detrusor overactivity: Clinical evaluation of onabotulinumtoxinA in a randomized, placebo‐controlled, double‐blind trial with an open‐label extension

Autor: Osamu Yokoyama, Masashi Honda, Takao Mogi, Takashi Nakayama, Ryosuke Takahashi, Tatsuma Matsuda

Publikováno v: International Journal of Urology

Objective To assess the efficacy and safety of botulinum toxin treatment (onabotulinumtoxinA 200 units) for Japanese patients with neurogenic detrusor overactivity caused by spinal cord injury or multiple sclerosis. Methods Patients with urinary inco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ecf6b188fa52b59593fecda8440b58
http://europepmc.org/articles/PMC8453759

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OnabotulinumtoxinA (botulinum toxin type A) for the treatment of Japanese patients with overactive bladder and urinary incontinence: Results of single‐dose treatment from a phase III, randomized, double‐blind, placebo‐controlled trial (interim analysis)

Autor: Osamu Yokoyama, Masashi Honda, Tomonori Yamanishi, Yuki Sekiguchi, Kenji Fujii, Takashi Nakayama, Takao Mogi, Takeya Kitta, Chikara Ohyama, Koichi Kambe, Yoshikatsu Tanahashi, Isoji Sasagawa, Mikinobu Ootani, Eiyu Nozawa, Toshihiko Saito, Fumio Manabe, Yasutomo Suzuki, Hikaru Tomoe, Satoru Takahashi, Nozomu Kawata, Hisashi Matsushima, Taketo Kawai, Manami Kinjo, Takashi Fukagai, Atsuko Takahashi, Fumio Nakajima, Haruaki Sasaki, Norihiko Okuno, Toshiyuki Itoi, Yoshiyuki Ishiura, Atsushi Mizokami, Yosuke Matsuta, Norifumi Sawada, Kosei Miwa, Atsushi Otsuka, Yasuhito Funahashi, Masaki Yoshida, Motoi Tobiume, Akihiro Kawauchi, Hiroshi Okuno, Terukazu Nakamura, Noriko Ninomiya, Chie Matsushita, Atsushi Takenaka, Takeshi Watanabe, Toyohiko Watanabe, Noritaka Ishito, Yasuyo Yamamoto, Hiroshi Ikeda, Narihito Seki, Shigehiro Kanegae, Kenichi Suyama, Kazuyuki Sagiyama, Noriaki Tokuda, Hideki Sakai, Hiroaki Nishimura, Motoshi Kawahara

Publikováno v: International Journal of Urology

OBJECTIVE To evaluate the efficacy and safety of onabotulinumtoxinA (botulinum toxin type A) 100 U in patients with overactive bladder and urinary incontinence. METHODS This was a phase III, randomized, double-blind, placebo-controlled trial in Japan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5945ddc99d0d90ffd95556e9c059fe0c
https://doi.org/10.1111/iju.14176

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Pulsatile drug release from poly (lactide-co-glycolide) microspheres: how does the composition of the polymer matrices affect the time interval between the initial burst and the pulsatile release of drugs?

Autor: Takehisa Nakajima, Masaru Yoshida, Kimiko Makino, Shizutoshi Ando, Takao Mogi, Hiroyuki Ohshima, Naoko Ohtake

Publikováno v: Colloids and Surfaces B: Biointerfaces. 19:173-179

Pulsatile release of estradiol was observed from poly (lactide-co-glycolide) microspheres, of which the monomer composition was 75% lactide and 25% glycolide. Estradiol was monolithically dissolved in the polymer matrices. The microspheres were immer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d99dba33ae73065e493153aefe1029f
https://doi.org/10.1016/s0927-7765(00)00148-x

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Sustained release of 17β-estradiol from poly (lactide-co-glycolide) microspheres in vitro and in vivo

Autor: Takao Mogi, Shizutoshi Ando, Takehisa Nakajima, Takeyo Tsukamoto, Naoko Ohtake, Rumi Chimura, Hiroyuki Ohshima, Yumi Kamaga, Hiroyuki Uenodan, Kimiko Makino, Masaru Yoshida, Yoshihisa Matsuda, Makoto Otsuka

Publikováno v: Colloids and Surfaces B: Biointerfaces. 17:153-165

Poly (lactide-co-glycolide) microspheres containing four different concentrations (0.15, 0.3, 1.5, 2.25% (w/w)) of 17β-estradiol, all of which are monolithic devices, were prepared by a solvent evaporation method. In the preparation process, poly (l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e56870bffd096a9c43cf8ec3f32290cf
https://doi.org/10.1016/s0927-7765(99)00105-8

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Therapeutic effect of in vivo sustained estradiol release from poly (lactide-co-glycolide) microspheres on bone mineral density of osteoporosis rats

Autor: Makoto, Otsuka, Hiroyuki, Uenodan, Yoshihisa, Matsuda, Takao, Mogi, Hiroyuki, Ohshima, Kimiko, Makino

Publikováno v: Bio-medical materials and engineering. 12(2)

Poly (lactide-co-glycolide or PLGA) microspheres containing 0.3% (w/w) of estradiol were prepared by a solvent evaporation method. These PLGA microspheres had a wide particle distribution between 0.5 and more than 100 microm. The average size was 76

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64fcef7bbff8b5e6c7d6669e0c1b325e
https://pubmed.ncbi.nlm.nih.gov/12122239

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Light scattering of a single microcapsule with a hydrogel membrane

Autor: Junko Masuda, Mikihito Takenaka, Kimiko Makino, Hiroyuki Ohshima, Benjamin Chu, Toshiaki Dobashi, Takayuki Narita, Takao Mogi

Publikováno v: Scopus-Elsevier

We have developed a light-scattering apparatus using a capillary tubing sample cell that is particularly suitable for investigating the structure of a single microcapsule. This approach is capable of determining the individual structures of polydispe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de469317d96013cf6154f1021cffa743
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031998856&partnerID=MN8TOARS

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