Výsledky vyhledávání - "Takao Matsuzaki"

Antiviral activity of curcumin and its analogs selected by an artificial intelligence-supported activity prediction system in SARS-CoV-2-infected VeroE6 cells

Autor: Koji Teshima, Takeshi Tanaka, Zhengmao Ye, Ken Ikeda, Takao Matsuzaki, Tamotsu Shiroma, Ayumu Muroya, Masato Hosoda, Mayo Yasugi, Hirotsugu Komatsu

Curcumin has been reported to exert its anti-SARS-CoV-2 activity by inhibiting the binding of spike receptor-binding domain (RBD) to angiotensin-converting enzyme-2 (ACE2). To identify more potent compounds, we evaluated the antiviral activities of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a56a345ea4f08d82515e295666d3fce

Zobrazit plný text záznamu

Identification of SARS-CoV-2 main protease inhibitors from FDA-approved drugs by artificial intelligence-supported activity prediction system

Autor: Hirotsugu Komatsu, Takeshi Tanaka, Zhengmao Ye, Ken Ikeda, Takao Matsuzaki, Mayo Yasugi, Masato Hosoda

Publikováno v: Journal of biomolecular structuredynamics.

Although a certain level of efficacy and safety of several vaccine products against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have been established, unmet medical needs for orally active small molecule therapeutic drugs are still v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b320e46c9d9f6387a871538420563c
https://pubmed.ncbi.nlm.nih.gov/34984963

Zobrazit plný text záznamu

Discovery of a Novel Small-molecule Interleukin-6 Inhibitor Through Virtual Screening Using Artificial Intelligence

Autor: Ikuo Kashiwakura, Hironori Yoshino, Masato Hosoda, Zhengmao Ye, Ken Ikeda, Takao Matsuzaki, Takeshi Tanaka, Masaru Yamaguchi, Hirotsugu Komatsu, Yoshiaki Sato

Publikováno v: Medicinal chemistry (Shariqah (United Arab Emirates)). 18(6)

Background: Interleukin-6 (IL-6) is a multifunctional cytokine involved in various cell functions and diseases. Thus far, several IL-6 inhibitors, such as humanized monoclonal antibody have been used to block excessive IL-6 signaling causing autoimmu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84f15409e18f70136120b387092b526
https://pubmed.ncbi.nlm.nih.gov/34784877

Zobrazit plný text záznamu

Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3β

Autor: Chizuko Sasaki, Masaaki Aoki, Ikuko Sugiura, Takehiro Yokota, Koichi Ishiguro, Takao Matsuzaki, Shigetoshi Sugio, Chieko Okumura, Tsukasa Hasegawa, Toshiyuki Kohno

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 60:439-446

Human tau-protein kinase I (TPK I; also known as glycogen synthase kinase 3 beta; GSK3 beta) is a serine/threonine protein kinase that participates in Alzheimer's disease. Here, binary complex structures of full-length TPK I/GSK3 beta with the ATP an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d856c4ae43b3c5ce4b795f8effba5815
https://doi.org/10.1107/s090744490302938x

Zobrazit plný text záznamu

Proteomic analysis of Epstein‐Barr virus‐transformed human B‐lymphoblastiod cell lines before and after immortalization

Autor: Akira Omori, Tosifusa Toda, Narimichi Kimura, Masanobu Sugimoto, Yasuhiro Furuichi, Takao Matsuzaki

Publikováno v: ELECTROPHORESIS. 21:1814-1822

Infection of human B lymphocytes with Epstein-Barr virus (EBV) induces proliferative B-lymphoblastoid cell lines (LCLs). However, the majority of EBV-transformed LCLs are mortal and unable to avoid cellular senescence. In our previous experiment, thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29e7c591c8e1f86e6b3d08699d24016b
https://doi.org/10.1002/(sici)1522-2683(20000501)21:9<1814::aid-elps1814>3.0.co

Zobrazit plný text záznamu

Crystallization and preliminary X-ray investigation of six new crystal forms of ribonuclease U2 from Ustilago sphaerogena

Autor: Shuji Noguchi, Yoshinori Satow, Chizuko Sasaki, Tsuneko Uchida, Takao Matsuzaki

Publikováno v: Journal of Crystal Growth. 168:270-274

Ribonuclease (RNase) U 2 is a purine-specific endoribonuclease secreted by Ustilago sphaerogena . In addition to type I and II crystals, six new crystal types of III, IV, V, VI, VII, and VIII have been obtained with the hanging-drop vapor-diffusion m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c6b4fe690de306a8eeeeca9d6b992a7
https://doi.org/10.1016/0022-0248(96)00330-2

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání