Výsledky vyhledávání - "Takao Mandai"

Akademický článek

T‐495, a novel low cooperative M1 receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointestinal side effect risk

Autor: Takao Mandai, Yuu Sako, Emi Kurimoto, Yuji Shimizu, Minoru Nakamura, Makoto Fushimi, Ryouta Maeda, Maki Miyamoto, Haruhide Kimura

Publikováno v: Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)

Abstract M1 muscarinic acetylcholine receptor (M1R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M1R activation causes gastrointestinal (GI) side effects in an

Externí odkaz: https://doaj.org/article/1996db5c1bb74209a2c1a0e72f2d9b18

Zobrazit plný text záznamu

In Vivo Pharmacological Comparison of TAK-071, a Positive Allosteric Modulator of Muscarinic M1 Receptor, and Xanomeline, an Agonist of Muscarinic M1/M4 Receptor, in Rodents

Autor: Takao Mandai, Maiko Tanaka, Haruhide Kimura, Motohisa Suzuki, Maki Kasahara, Atsushi Nakatani, Emi Kurimoto

Publikováno v: Neuroscience. 414:60-76

Activation of the M1 muscarinic acetylcholine receptor (M1R) may be an effective therapeutic approach for Alzheimer's disease (AD), dementia with Lewy bodies, and schizophrenia. Previously, the M1R/M4R agonist xanomeline was shown to improve cognitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::244f3a1fc436e426d825bddb766b56e5
https://doi.org/10.1016/j.neuroscience.2019.07.003

Zobrazit plný text záznamu

Autor: Yuji Shimizu, Yuu Sako, Takao Mandai, Haruhide Kimura, Emi Kurimoto, Ryouta Maeda, Maki Miyamoto, Makoto Fushimi, Minoru Nakamura

Publikováno v: Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)

M1 muscarinic acetylcholine receptor (M1R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M1R activation causes gastrointestinal (GI) side effects in animals. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72150c40b53a4ad05b7794f62f164063
https://doaj.org/article/1996db5c1bb74209a2c1a0e72f2d9b18

Zobrazit plný text záznamu

T-495, a novel low cooperative M

Autor: Takao, Mandai, Yuu, Sako, Emi, Kurimoto, Yuji, Shimizu, Minoru, Nakamura, Makoto, Fushimi, Ryouta, Maeda, Maki, Miyamoto, Haruhide, Kimura

Publikováno v: Pharmacology Research & Perspectives

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37e078f1c932cf86cd270bd3cd9e9cd6
https://pubmed.ncbi.nlm.nih.gov/31990455

Zobrazit plný text záznamu

TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects

Autor: Atsushi Suzuki, Haruhide Kimura, Motohisa Suzuki, Yuu Sako, Takao Mandai, Masami Yamada, Maiko Tanaka, Emi Kurimoto, Yuji Shimizu

Publikováno v: Neuropsychopharmacology. 44:950-960

The muscarinic M(1) receptor (M(1)R) is a promising target for treating cognitive impairment associated with cholinergic deficits in disorders such as Alzheimer’s disease and schizophrenia. We previously reported that cooperativity (α-value) was k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5f4946428dada431d0c6c8b5684cd2
https://doi.org/10.1038/s41386-018-0168-8

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání