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Akademický článek

The GLP-1 Receptor Agonist Liraglutide Decreases Primary Bile Acids and Serotonin in the Colon Independently of Feeding in Mice

Autor: Katsunori Nonogaki, Takao Kaji

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 14, p 7784 (2024)

Liraglutide, a glucagon-like peptide 1 analog used to treat type 2 diabetes and obesity, is a potential new treatment modality for bile acid (BA) diarrhea. Here, we show that administration of liraglutide significantly decreased total BAs, especially

Externí odkaz: https://doaj.org/article/fbaa668a32204fec80e521f28802673e

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Akademický článek

Ingestion of whey protein and β-conglycinin exerts opposite effects on intestinal FGF15 and serotonin secretion in mice

Autor: Katsunori Nonogaki, Takao Kaji

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

Farnesoid X receptor (FXR) and Takeda G protein-coupled Receptor 5 (TGR5), the intestinal bile acid (BA) receptors, regulate the gut-derived hormones including fibroblast growth factor 15/19 (FGF15/19) and serotonin (5-hydrooxytryptamine, 5-HT). Here

Externí odkaz: https://doaj.org/article/18907a92c5bf4bad87e66f4ff99023e1

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Akademický článek

Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and KKAy mice

Autor: Katsunori Nonogaki, Takao Kaji

Publikováno v: Heliyon, Vol 6, Iss 12, Pp e05774- (2020)

Plasma fibroblast growth factor 21 (FGF21) levels and hepatic FGF21, serotonin 2a receptor (htr2a), and stromal cell-derived factor 2 like 1 (Sdf2l1) expression are increased in insulin-resistant C57BL6J mice fed a high-fat diet. Here we show that pl

Externí odkaz: https://doaj.org/article/be26db61e8d34ca2be453e89f10d570f

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Akademický článek

Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice

Autor: Katsunori Nonogaki, Takao Kaji

Publikováno v: Journal of Diabetes Research, Vol 2018 (2018)

A recent report suggested that brain-derived serotonin (5-HT) is critical for maintaining weight loss induced by glucagon-like peptide-1 (GLP-1) receptor activation in rats and that 5-HT2A receptors mediate the feeding suppression and weight loss ind

Externí odkaz: https://doaj.org/article/f5bb7b12208a44a58e2ab3b5aa8f9f16

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Ingestion of whey protein and beta-conglycinin exerts opposite effects on intestinal FGF15-mediated hepatic bile acid synthesis in mice

Autor: Katsunori Nonogaki, Takao Kaji

Farnesoid X receptor (FXR), a BA receptor, and fibroblast growth factor 15 (FGF15) regulate enterohepatic circulation of BAs, glucose, and lipid metabolism. Here we show that ingestion of whey protein isolate, a milk protein, significantly increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c3014a0e6a385c97bfa63f5a6408c93
https://doi.org/10.21203/rs.3.rs-1769210/v1

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Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and KKAy mice

Autor: Takao Kaji, Katsunori Nonogaki

Publikováno v: Heliyon, Vol 6, Iss 12, Pp e05774-(2020)
Heliyon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d1d0ef99b180cd7c72c86029eb63fe
http://www.sciencedirect.com/science/article/pii/S2405844020326177

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Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet

Autor: Katsunori Nonogaki, Takao Kaji

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)

Insufficient expression of hepatic fibroblast growth factor 21 (FGF21) and stromal cell-derived factor 2 like 1 (Sdf2l1) reportedly leads to insulin resistance and hepatosteatosis in obesity and type 2 diabetes. On the other hand, increased expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e4a6d4580fd589ead18a6a6c57093a
https://doi.org/10.1038/s41598-020-72975-8

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Akademický článek

Amphioxus mouth after dorso-ventral inversion.

Autor: Takao Kaji^1,2, Reimer, James D.³, Morov, Arseniy R.^1,4, Shigeru Kuratani⁵, Kinya Yasui¹ furaha@sci.hiroshima-u.ac.jp

Publikováno v: Zoological Letters. 2/6/2016, Vol. 2, p1-14. 14p.

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A Tryptophan Hydroxylase Inhibitor Increases Hepatic FGF21 Production and Decreases Hepatic Gluconeogenesis Independently of Insulin in db/db Mice

Autor: Katsunori Nonogaki, Takao Kaji, Mari Murakami

Publikováno v: Neuropsychiatry.

Background The aim of our study is to determine circulating fibroblast growth factor (FGF21) levels in obese and diabetic db/db mice, and role of serotonin (5-HT) in the regulation of hepatic FGF21 expression and circulating FGF21 levels in relation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0932930d361ed7c0c2312662a7e0ab9
https://doi.org/10.4172/neuropsychiatry.1000480

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A Tryptophan Hydroxylase Inhibitor Decreases Hepatic FGF21 Expression and Circulating FGF21 in Mice Fed A High-Fat Diet

Autor: Katsunori Nonogaki, Mari Murakami, Takao Kaji

Publikováno v: Neuropsychiatry.

Background: Fibroblast growth factor 21 (FGF21) is primarily secreted by the liver as an endocrine hormone, and circulating FGF21 levels are elevated in mice with diet-induced obesity and an insulin-resistant state. The aim of our study was to determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c40de8e280d1cb9242af5004c3164fe6
https://doi.org/10.4172/neuropsychiatry.1000358

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