Identification and clinical significance of somatic oncogenic mutations in epithelial ovarian cancer

Autor: Takafumi Watanabe, Hideaki Nanamiya, Yuta Endo, Manabu Kojima, Shinji Nomura, Shigenori Furukawa, Shu Soeda, Hirosumi Tamura, Masae Ryufuku, Daisuke Tanaka, Takao Isogai, Jun-ichi Imai, Shinya Watanabe, Keiya Fujimori

Publikováno v: Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-9 (2021)

Abstract Objective Epithelial ovarian cancer (EOC) is a heterogeneous disease with diverse clinicopathological features and behaviors, and its heterogeneity may be concerned with the accumulation of multiple somatic oncogenic mutations. The major goa

Externí odkaz: https://doaj.org/article/8cce3126c5654d118cdfe764c677a547

Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter.

Autor: Chikara Kaito, Hirono Yoshikai, Ai Wakamatsu, Atsushi Miyashita, Yasuhiko Matsumoto, Tomoko Fujiyuki, Masaru Kato, Yoshitoshi Ogura, Tetsuya Hayashi, Takao Isogai, Kazuhisa Sekimizu

Publikováno v: PLoS Pathogens, Vol 16, Iss 4, p e1008469 (2020)

The molecular mechanisms that allow pathogenic bacteria to infect animals have been intensively studied. On the other hand, the molecular mechanisms by which bacteria acquire virulence functions are not fully understood. In the present study, we expe

Externí odkaz: https://doaj.org/article/623eabb0e7f449289d218cf660bd2477

Integrative annotation of 21,037 human genes validated by full-length cDNA clones.

Autor: Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O Koyanagi, Roberto A Barrero, Takuro Tamura, Yumi Yamaguchi-Kabata, Motohiko Tanino, Kei Yura, Satoru Miyazaki, Kazuho Ikeo, Keiichi Homma, Arek Kasprzyk, Tetsuo Nishikawa, Mika Hirakawa, Jean Thierry-Mieg, Danielle Thierry-Mieg, Jennifer Ashurst, Libin Jia, Mitsuteru Nakao, Michael A Thomas, Nicola Mulder, Youla Karavidopoulou, Lihua Jin, Sangsoo Kim, Tomohiro Yasuda, Boris Lenhard, Eric Eveno, Yoshiyuki Suzuki, Chisato Yamasaki, Jun-ichi Takeda, Craig Gough, Phillip Hilton, Yasuyuki Fujii, Hiroaki Sakai, Susumu Tanaka, Clara Amid, Matthew Bellgard, Maria de Fatima Bonaldo, Hidemasa Bono, Susan K Bromberg, Anthony J Brookes, Elspeth Bruford, Piero Carninci, Claude Chelala, Christine Couillault, Sandro J de Souza, Marie-Anne Debily, Marie-Dominique Devignes, Inna Dubchak, Toshinori Endo, Anne Estreicher, Eduardo Eyras, Kaoru Fukami-Kobayashi, Gopal R Gopinath, Esther Graudens, Yoonsoo Hahn, Michael Han, Ze-Guang Han, Kousuke Hanada, Hideki Hanaoka, Erimi Harada, Katsuyuki Hashimoto, Ursula Hinz, Momoki Hirai, Teruyoshi Hishiki, Ian Hopkinson, Sandrine Imbeaud, Hidetoshi Inoko, Alexander Kanapin, Yayoi Kaneko, Takeya Kasukawa, Janet Kelso, Paul Kersey, Reiko Kikuno, Kouichi Kimura, Bernhard Korn, Vladimir Kuryshev, Izabela Makalowska, Takashi Makino, Shuhei Mano, Regine Mariage-Samson, Jun Mashima, Hideo Matsuda, Hans-Werner Mewes, Shinsei Minoshima, Keiichi Nagai, Hideki Nagasaki, Naoki Nagata, Rajni Nigam, Osamu Ogasawara, Osamu Ohara, Masafumi Ohtsubo, Norihiro Okada, Toshihisa Okido, Satoshi Oota, Motonori Ota, Toshio Ota, Tetsuji Otsuki, Dominique Piatier-Tonneau, Annemarie Poustka, Shuang-Xi Ren, Naruya Saitou, Katsunaga Sakai, Shigetaka Sakamoto, Ryuichi Sakate, Ingo Schupp, Florence Servant, Stephen Sherry, Rie Shiba, Nobuyoshi Shimizu, Mary Shimoyama, Andrew J Simpson, Bento Soares, Charles Steward, Makiko Suwa, Mami Suzuki, Aiko Takahashi, Gen Tamiya, Hiroshi Tanaka, Todd Taylor, Joseph D Terwilliger, Per Unneberg, Vamsi Veeramachaneni, Shinya Watanabe, Laurens Wilming, Norikazu Yasuda, Hyang-Sook Yoo, Marvin Stodolsky, Wojciech Makalowski, Mitiko Go, Kenta Nakai, Toshihisa Takagi, Minoru Kanehisa, Yoshiyuki Sakaki, John Quackenbush, Yasushi Okazaki, Yoshihide Hayashizaki, Winston Hide, Ranajit Chakraborty, Ken Nishikawa, Hideaki Sugawara, Yoshio Tateno, Zhu Chen, Michio Oishi, Peter Tonellato, Rolf Apweiler, Kousaku Okubo, Lukas Wagner, Stefan Wiemann, Robert L Strausberg, Takao Isogai, Charles Auffray, Nobuo Nomura, Takashi Gojobori, Sumio Sugano

Publikováno v: PLoS Biology, Vol 2, Iss 6, p e162 (2004)

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigatio

Externí odkaz: https://doaj.org/article/06eb24ad78484cfc8526622555aa94d3

Tumor β‑catenin expression is associated with immune evasion in non‑small cell lung cancer with high tumor mutation burden

Autor: Satoshi Muto, Hiroyuki Suzuki, Hikaru Yamaguchi, Takeo Hasegawa, Yuki Ozaki, Yuki Matsumura, Takao Isogai, Mitsunori Higuchi, Mika Hoshino, Mitsuro Fukuhara, Takumi Yamaura, Jun-ichi Imai, Masayuki Watanabe, Shinya Watanabe, Hideaki Nanamiya, Hayato Mine, Jun Osugi, Takuya Inoue, Hironori Takagi, Yutaka Shio, Naoyuki Okabe

Publikováno v: Oncology Letters

β-catenin expression by tumor cells suppressed dendritic cell recruitment to the tumor microenvironment in a melanoma model, resulting in fewer tumor-infiltrating lymphocytes. Immunohistochemistry was used in the present study to examine the associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b8a3396a5fc226b40c9878fd3b31d8
https://doi.org/10.3892/ol.2021.12464

Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter

Autor: Kazuhisa Sekimizu, Takao Isogai, Tetsuya Hayashi, Hirono Yoshikai, Masaru Kato, Tomoko Fujiyuki, Atsushi Miyashita, Chikara Kaito, Yoshitoshi Ogura, Ai Wakamatsu, Yasuhiko Matsumoto

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 4, p e1008469 (2020)

The molecular mechanisms that allow pathogenic bacteria to infect animals have been intensively studied. On the other hand, the molecular mechanisms by which bacteria acquire virulence functions are not fully understood. In the present study, we expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c3d968b2eef509e2f8337f944b9030
http://europepmc.org/articles/PMC7179839