Zobrazeno 1 - 10
of 339
pro vyhledávání: '"Takao Hamakubo"'
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 973 (2024)
Background: Photodynamic therapy (PDT) is a cancer-targeted treatment that uses a photosensitizer (PS) and irradiation of a specific wavelength to exert cytotoxic effects. To enhance the antitumor effect against head and neck squamous cell carcinoma
Externí odkaz:
https://doaj.org/article/efdd13239dda42a0abae7b5d8de95bee
Autor:
Titouan Jaunet-Lahary, Tatsuro Shimamura, Masahiro Hayashi, Norimichi Nomura, Kouta Hirasawa, Tetsuya Shimizu, Masao Yamashita, Naotaka Tsutsumi, Yuta Suehiro, Keiichi Kojima, Yuki Sudo, Takashi Tamura, Hiroko Iwanari, Takao Hamakubo, So Iwata, Kei-ichi Okazaki, Teruhisa Hirai, Atsuko Yamashita
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract An oxalate-degrading bacterium in the gut microbiota absorbs food-derived oxalate to use this as a carbon and energy source, thereby reducing the risk of kidney stone formation in host animals. The bacterial oxalate transporter OxlT selectiv
Externí odkaz:
https://doaj.org/article/de2c77162a52411e8b5bf5628545b201
Publikováno v:
Thoracic Cancer, Vol 14, Iss 7, Pp 645-653 (2023)
Abstract Background Photodynamic therapy (PDT) is a cancer‐targeted treatment that uses a photosensitizer (PS) and laser irradiation. The effectiveness of current PDT using red light for advanced cancers is limited, because red light can only reach
Externí odkaz:
https://doaj.org/article/dd8fce0c5bbd4975b201f689f532afd3
Autor:
Titouan Jaunet-Lahary, Tatsuro Shimamura, Masahiro Hayashi, Norimichi Nomura, Kouta Hirasawa, Tetsuya Shimizu, Masao Yamashita, Naotaka Tsutsumi, Yuta Suehiro, Keiichi Kojima, Yuki Sudo, Takashi Tamura, Hiroko Iwanari, Takao Hamakubo, So Iwata, Kei-ichi Okazaki, Teruhisa Hirai, Atsuko Yamashita
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/9be3c076e3ae4fe6ae061a608a4997d4
Autor:
Toshiyuki Kitoh, Tsuyoshi Ohara, Taichiro Muto, Akihisa Okumura, Reizo Baba, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo, Kenji Daigo, Takao Hamakubo
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Kawasaki disease (KD) is a febrile disease of childhood characterized by systemic vasculitis that can lead to coronary artery lesions (CAL). This was a prospective cohort study to determine the levels of the pentraxin 3 (PTX3), soluble CD24-Subtype (
Externí odkaz:
https://doaj.org/article/715bd78a8b214f3a8b57ab825301d468
Publikováno v:
Biochemistry and Biophysics Reports, Vol 24, Iss , Pp 100850- (2020)
Angiotensin II (Ang II) type 2 receptor (AT2R) is one of the major components of the renin-angiotensin-aldosterone system. Nevertheless, the physiological role is not well defined compared to the understanding of the Ang II type 1 receptor (AT1R), wh
Externí odkaz:
https://doaj.org/article/49d46f3fbaa64f5cba08ea68919ac2b1
Autor:
Hiroki Akiba, Kensuke Takayanagi, Osamu Kusano-Arai, Hiroko Iwanari, Takao Hamakubo, Kouhei Tsumoto
Publikováno v:
Biotechnology Reports, Vol 25, Iss , Pp - (2020)
Biparatopic fragment antibodies can overcome deficiencies in avidity of conventional antibody fragments. Here, we describe a technology for generating biparatopic antibodies through two-step targeting using a pair of polypeptides, SpyTag and SpyCatch
Externí odkaz:
https://doaj.org/article/9d3f9c99a3f54c199b1c54719f8bac67
Autor:
Taichi Miura, Masahiko Kume, Takeshi Kawamura, Kazuo Yamamoto, Takao Hamakubo, Shoko Nishihara
Publikováno v:
Stem Cell Reports, Vol 10, Iss 1, Pp 272-286 (2018)
Summary: Mouse embryonic stem cells (ESCs) differentiate into multiple cell types during organismal development. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from ESCs via the phosphorylation of downstream molecules such as mit
Externí odkaz:
https://doaj.org/article/c0cd61de082b4e72af90d2b34493aa99
Autor:
Ayano Kondo, Shogo Yamamoto, Ryo Nakaki, Teppei Shimamura, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Tetsuo Yoshida, Hiroyuki Aburatani, Tsuyoshi Osawa
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2228-2242 (2017)
Summary: Conditions of the tumor microenvironment, such as hypoxia and nutrient starvation, play critical roles in cancer progression. However, the role of acidic extracellular pH in cancer progression is not studied as extensively as that of hypoxia
Externí odkaz:
https://doaj.org/article/7715b4e13e444487bfa1d5e7a4016e8e
Autor:
Riuko Ohashi, Hajime Umezu, Ayako Sato, Tatsuya Abé, Shuhei Kondo, Kenji Daigo, Seijiro Sato, Norikazu Hara, Akinori Miyashita, Takeshi Ikeuchi, Teiichi Motoyama, Masashi Kishi, Tadahiro Nagaoka, Keiko Horiuchi, Atsushi Shiga, Shujiro Okuda, Tomoki Sekiya, Aya Ohtsubo, Kosuke Ichikawa, Hiroshi Kagamu, Toshiaki Kikuchi, Satoshi Watanabe, Jun-Ichi Tanuma, Peter Schraml, Takao Hamakubo, Masanori Tsuchida, Yoichi Ajioka
Publikováno v:
Cells, Vol 9, Iss 11, p 2409 (2020)
Ribosomal RNA (rRNA), the most abundant non-coding RNA species, is a major component of the ribosome. Impaired ribosome biogenesis causes the dysfunction of protein synthesis and diseases called “ribosomopathies,” including genetic disorders with
Externí odkaz:
https://doaj.org/article/bbb0d54a6cf148f4a62a2177a1c8183c