Výsledky vyhledávání - "Takao, Nammo"

Akademický článek

Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells

Autor: Haruhide Udagawa, Nobuaki Funahashi, Wataru Nishimura, Takashi Uebanso, Miho Kawaguchi, Riku Asahi, Shigeru Nakajima, Takao Nammo, Masaki Hiramoto, Kazuki Yasuda

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract The mechanisms of impaired glucose-induced insulin secretion from the pancreatic β-cells in obesity have not yet been completely elucidated. Here, we aimed to assess the effects of adipocyte-derived factors on the functioning of pancreatic

Externí odkaz: https://doaj.org/article/776401123a8948508e6b6a6f4767a61c

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Akademický článek

Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes

Autor: Harutoshi Ozawa, Kenji Fukui, Yukari Fujita, Chisaki Ishibashi, Sho Yoneda, Takao Nammo, Shingo Fujita, Megu Yamaguchi Baden, Takekazu Kimura, Ayumi Tokunaga, Junji Kozawa, Hidetoshi Eguchi, Iichiro Shimomura

Publikováno v: Journal of Diabetes, Vol 15, Iss 3, Pp 277-282 (2023)

Highlights We examined whether maximum body mass index (BMI) before the onset of diabetes (MBBO) affects histological findings of islet cells. We divided patients into two groups according to an MBBO cutoff of 25 kg/m2 or BMI cutoff of 21 kg/m2. We c

Externí odkaz: https://doaj.org/article/1c0df11db2564474beeb95b1b8a5ef8b

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Akademický článek

Relationships between intra-pancreatic fat deposition and lifestyle factors: a cross-sectional study

Autor: Kento Mitsushio, Megu Y. Baden, Sarasa Kato, Akiko Niki, Harutoshi Ozawa, Saori Motoda, Chisaki Ishibashi, Yoshiya Hosokawa, Yukari Fujita, Ayumi Tokunaga, Takao Nammo, Junji Kozawa, Iichiro Shimomura

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

AimsThe excess deposition of intra-pancreatic fat deposition (IPFD) has been reported to be associated with type 2 diabetes, chronic pancreatitis, and pancreatic ductal adenocarcinoma. In the current study, we aimed to identify a relationship between

Externí odkaz: https://doaj.org/article/8f374f4198ed4ecda99749d79dddb691

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Akademický článek

Lipid droplet accumulation in β cells in patients with type 2 diabetes is associated with insulin resistance, hyperglycemia and β cell dysfunction involving decreased insulin granules

Autor: Tomomi Horii, Junji Kozawa, Yukari Fujita, Satoshi Kawata, Harutoshi Ozawa, Chisaki Ishibashi, Sho Yoneda, Takao Nammo, Jun-ichiro Miyagawa, Hidetoshi Eguchi, Iichiro Shimomura

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Background and objectivePancreatic fat is a form of ectopic fat. Lipid droplets (LDs) are also observed in β cells; however, the pathophysiological significance, especially for β cell function, has not been elucidated. Our aim was to assess LD accu

Externí odkaz: https://doaj.org/article/05f477787fe140489215f8e58ca8e31d

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Akademický článek

Consumption of two meals per day is associated with increased intrapancreatic fat deposition in patients with type 2 diabetes: a retrospective study

Autor: Tomomi Horii, Yukari Fujita, Chisaki Ishibashi, Kenji Fukui, Junji Kozawa, Iichiro Shimomura, Harutoshi Ozawa, Shingo Fujita, Takekazu Kimura, Ayumi Tokunaga, Akiko Niki, Megu Y Baden, Sarasa Kato, Kento Mitsushio, Takao Nammo

Publikováno v: BMJ Open Diabetes Research & Care, Vol 10, Iss 5 (2022)

Introduction This study aimed to identify the associations between lifestyle factors and intrapancreatic fat deposition in patients with type 2 diabetes.Research design and methods The participants were 185 patients with type 2 diabetes who were hosp

Externí odkaz: https://doaj.org/article/870a4a60a76040bfb30a0fa66f43b58a

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Akademický článek

Characterization of the taste receptor‐related G‐protein, α‐gustducin, in pancreatic β‐cells

Autor: Haruhide Udagawa, Masaki Hiramoto, Miho Kawaguchi, Takashi Uebanso, Mica Ohara‐Imaizumi, Takao Nammo, Wataru Nishimura, Kazuki Yasuda

Publikováno v: Journal of Diabetes Investigation, Vol 11, Iss 4, Pp 814-822 (2020)

Abstract Aims/Introduction Taste receptors, T1rs and T2rs, and the taste‐selective G‐protein, α‐gustducin, are expressed outside the taste‐sensing system, such as enteroendocrine L cells. Here, we examined whether α‐gustducin also affects

Externí odkaz: https://doaj.org/article/95d7e6014abe493b8c3c067043a71b4d

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