Výsledky vyhledávání

Structural optimization of alkyl-substituted 2-(7-5H-[1]benzopyrano[2,3-b]pyridyl)propionic acid as anti-inflammatory agents

Autor: Yuko Nagamatsu, Ichimaro Yamada, Takanori Oe, Mamoru Matsuura, Hiroshi Ochi, Yoichi Naka

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:959-962

Several alkyl-analogues of pranoprofen were synthesized and their cyclooxygenase inhibitory activities were evaluated in a screening test. The chosen compounds were analyzed on the relationships between structure, lipophilicity (log P) and cell bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a3b61f4c019da9fa9fdc8f2353e5473
https://doi.org/10.1016/0960-894x(95)00141-f

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of 1-Phenylpyrazoles as Xanthine Oxidase Inhibitors

Autor: Atsushi Fukunari, Takanori Oe, Yoichi Naka, Seigo Ishibuchi, Tsuguo Ikebe, Hiroshi Morimoto, Ichimaro Yamada, Miho Kamezawa, Hiroyoshi Inoue

Publikováno v: ChemInform. 32

A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78fdbfd650314b9307c626149025262b
https://doi.org/10.1002/chin.200150107

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Enhancement of host defense by Y-25510, (±)-3-[4-(2-dimethylamino-1-methylethoxy) phenyl]-1H-pyrazolo[3, 4-b]pyridine-1-acetic acid, a novel synthetic compound. A comparison with recombinant human granulocyte colony-stimulating factor in 5-fluorouracil-treated mice

Autor: Masao Hisadome, Tetsuko Fukuda, Takanori Oe, Michio Terasawa, Kazuhiro Goto, Hiromi Takahata, Kikuo Nomoto, Sumiaki Tsuru

Publikováno v: International Journal of Immunopharmacology. 14:1195-1201

The effect of a novel synthetic compound, Y-25510, (+-)-3-[4-(2-dimethylamino-1-methylethoxy)phenyl]-1H-pyrazolo[3,4 -b] pyridine-1-acetic acid, on recovery from long-lasting leukopenia induced by 5-fluorouracil was compared with that of recombinant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b601ab9dd0dd0dfdfe903eb1e4ef8a
https://doi.org/10.1016/0192-0561(92)90055-p

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Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors

Autor: Hiroshi Morimoto, Tsuguo Ikebe, Atsushi Fukunari, Yoichi Naka, Takanori Oe, Ichimaro Yamada, Seigo Ishibuchi, Hiroyoshi Inoue, Miho Kamezawa

Publikováno v: Bioorganicmedicinal chemistry letters. 11(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7106faab40971656ad68c7636cf3101a
https://pubmed.ncbi.nlm.nih.gov/11294382

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Anti-allergic activity of 7-acetyl-5-oxo-5H-[1]benzopyrano[2, 3-b]pyridine(Y-9000)

Autor: Takanori Oe, Michio Terasawa, Kazuhiro Goto, Yutaka Maruyama

Publikováno v: Folia Pharmacologica Japonica. 74:179-191

新規化合物7-acctyl-5-oxo・5H[1]benzopyrano[2,3-b]pyridine（Y-9000）の抗アレルギー作用について，disodium cromoglycate（DSCG）と比較検討した．Y-9000はegg albuminおよびDNP-ascarisを抗原として用いたラット�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::341bd6dccc65d4f3220fe2a8989ebaa7
https://doi.org/10.1254/fpj.74.179

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Thromboxane Synthetase Inhihitors. I. Synthesis of Some Imidazolylarylmethanols and Their Inhihitory Activity on Platelet Aggregation

Autor: Tetsuya Tahara, Shinro Setoguchi, Hiroshi Mikashima, Yoichi Naka, Kazuyuki Kawasaki, Takanori Oe, Mineo Tsuruda

Publikováno v: YAKUGAKU ZASSHI. 109:33-45

Several imidazolylpyridinemethanols and imidazolylbenzenemethanols were prepared and evaluated for an inhibitory activity against arachidonic acid-induced platelet aggregation. The result shows that the arylmethanol moiety is essential for the activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d0d4e8699f9d549f843fd99558ddd9
https://doi.org/10.1248/yakushi1947.109.1_33

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[Studies on anti-inflammatory agents. XXXI. Studies on the synthesis and anti-inflammatory activity of xanthenyl- and benzopyranopyridinylacetic acid derivatives (author's transl)]

Autor: MICHIO NAKANISHI, TAKANORI OE, MINEO TSURUDA, HIROSHI MATSUO, SHUNJI SAKURAGI, YUTAKA MARUYAMA

Publikováno v: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 96(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5271764a7f68c3dbb29a47bfd1e8c619
https://pubmed.ncbi.nlm.nih.gov/943518

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ChemInform Abstract: Thromboxane Synthetase Inhibitors. Part 1. Synthesis of Some Imidazolylarylmethanols and Their Inhibitory Activity on Platelet Aggregation

Autor: K. Kawasaki, Takanori Oe, Shinro Setoguchi, Y. Naka, T. Tahara, Mineo Tsuruda, H. Mikashima

Publikováno v: ChemInform. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bebcf9e9c369cca2819929ff551b860
https://doi.org/10.1002/chin.198937218

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ChemInform Abstract: STUDIES ON ANTI-INFLAMMATORY AGENTS. XXXI. STUDIES ON THE SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF XANTHENYL- AND BENZOPYRANOPYRIDINYLACETIC ACID DERIVATIVES

Autor: S. Sakuragi, Michio Nakanishi, Y. Maruyama, Mineo Tsuruda, Takanori Oe, H. Matsuo

Publikováno v: Chemischer Informationsdienst. 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5585c02e3c9b4bc97a93f6fc50ef52d1
https://doi.org/10.1002/chin.197625360

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