Výsledky vyhledávání - "Takanori Muto"

Site-specific unglycosylation to improve crystallization of the metabotropic glutamate receptor 3 extracellular domain

Autor: Hisato Jingami, Kosuke Morikawa, Daisuke Tsuchiya, Takanori Muto

Publikováno v: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 65:236-241

Metabotropic glutamate receptors (mGluRs) are involved in the regulation of many physiological and pathological processes in the central nervous system. The extracellular domain (ECD) of mGluR subtype 3 (mGluR3) was produced using the baculovirus exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a80a97d9a9022cbc656e199fc9dd43b
https://doi.org/10.1107/s1744309109002267

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Expression, purification, crystallization and preliminary X-ray analysis of the ligand-binding domain of metabotropic glutamate receptor 7

Autor: Kosuke Morikawa, Takanori Muto, Daisuke Tsuchiya, Hisato Jingami

Publikováno v: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 63:627-630

Glutamate is the major excitatory neurotransmitter and its metabotropic glutamate receptor (mGluR) plays an important role in the central nervous system. The ligand-binding domain (LBD) of mGluR subtype 7 (mGluR7) was produced using the baculovirus e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82473ff961e0fa5cb35bee3691449cb9
https://doi.org/10.1107/s1744309107030059

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Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation

Autor: Takanori Muto, Takuji Oyama, Hisato Jingami, Takuma Sugi, Shigetada Nakanishi, Kosuke Morikawa

Publikováno v: The EMBO Journal. 26:2192-2205

Metabotropic glutamate receptors (mGluRs) function as neuronal G-protein-coupled receptors and this requires efficient membrane targeting through associations with cytoplasmic proteins. However, the molecular mechanism regulating mGluR cell-surface t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888f0f0444f4f72c21654c32d6f05455
https://doi.org/10.1038/sj.emboj.7601651

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Phosphorylation and Recruitment of Syk by Immunoreceptor Tyrosine-based Activation Motif-based Phosphorylation of Tamalin

Autor: Masayuki Hirose, Shigeru Yanagi, Takanori Muto, Yoshiaki Nakajima, Hirohei Yamamura, Koki Moriyoshi, Jun Kitano, Shigetada Nakanishi, Hisato Jingami

Publikováno v: Journal of Biological Chemistry. 279:32308-32315

Tamalin is a scaffold protein that forms a multiple protein assembly including metabotropic glutamate receptors (mGluRs) and several postsynaptic and protein-trafficking scaffold proteins in distinct mode of protein-protein association. In the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35099f57edc13351f40d7b2f4e1992e7
https://doi.org/10.1074/jbc.m400547200

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Mutant FGF-23 Responsible for Autosomal Dominant Hypophosphatemic Rickets Is Resistant to Proteolytic Cleavage and Causes Hypophosphatemia in Vivo

Autor: Seiji Fukumoto, Takashi Shimada, Takanori Muto, Yuji Yamazaki, Katsuya Okawa, Takashi Yoneya, Yasuhiro Takeuchi, Itaru Urakawa, Toshiro Fujita, Takeyoshi Yamashita

Publikováno v: Endocrinology. 143:3179-3182

FGF-23 is involved in the pathogenesis of two similar hypophosphatemic diseases, autosomal dominant hypophosphatemic rickets/osteomalacia (ADHR) and tumor-induced osteomalacia (TIO). We have shown that the overproduction of FGF-23 by tumors causes TI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83806d5c876cb4e4de9adcdc0907d9cd
https://doi.org/10.1210/endo.143.8.8795

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NMR identification of the Tom20 binding segment in mitochondrial presequences

Autor: Takayuki Obita, Daisuke Kohda, Takanori Muto, Toshiya Endo, Toshihiro Shodai, Yoshito Abe

Publikováno v: Journal of Molecular Biology. 306:137-143

Many mitochondrial proteins are synthesized in the cytosol as precursors with N-terminal presequences, and are imported into mitochondria with the aid of translocator protein complexes containing presequence-binding proteins. Tom20, a receptor protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367b9ccb152400c30453de304a9c23f0
https://doi.org/10.1006/jmbi.2000.4397

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Functional Analysis of the C-terminal Region of Recombinant Human Thrombopoietin

Autor: Tadashi Ozawa, Youko Kudou, Yoshihiro Shimada, Takanori Muto, Takashi Kato, Michael D. Feese, Hiroshi Miyazaki, Tomoyuki Okamoto, Kinya Ogami, Hideya Ohashi, Ryota Kuroki, Tomoyuki Tahara

Publikováno v: Journal of Biological Chemistry. 275:12090-12094

Thrombopoietin (TPO) is a cytokine that primarily stimulates megakaryocytopoiesis and thrombopoiesis. TPO has a unique C-terminal tail peptide of about 160 amino acids that consists mostly of hydrophilic residues and contains six N-linked sugar chain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ede19990d48d1a777a4c5b31e7b45bbe
https://doi.org/10.1074/jbc.275.16.12090

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Crystallographic and Functional Studies of Very Short Patch Repair Endonuclease

Autor: Takanori Muto, Susan E. Tsutakawa, Mariko Ariyoshi, Kosuke Morikawa, Hisato Jingami, Naoki Kunishima, Tomohiko Kawate, Daisuke Kohda, Masako Nakagawa

Publikováno v: Molecular Cell. 3(5):621-628

Vsr endonuclease plays a crucial role in the repair of TG mismatched base pairs, which are generated by the spontaneous degradation of methylated cytidines; Vsr recognizes the mismatched base pair and cleaves the phosphate backbone 5' to the thymidin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7e3dc6e6f9d6af84fbd521e67fafc2

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