Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Takanori Maejima"'
Autor:
Toshinori Agatsuma, Yuki Abe, Takashi Nakada, Ichiro Hayakawa, Tetsuo Aida, Tomoko Shibutani, Yumi Nishiya, Akiko Watanabe, Kazuyoshi Kumagai, Chiharu Hattori, Takanori Maejima, Jun Hasegawa, Michiko Yamato
Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2555c866d4671115aaf3d352455d62eb
https://doi.org/10.1158/1535-7163.22521898.v1
https://doi.org/10.1158/1535-7163.22521898.v1
Autor:
Toshinori Agatsuma, Yuki Abe, Masato Murakami, Yutaka Noguchi, Hirofumi Hamada, Miki Yamaguchi, Shu Takahashi, Riki Goto, Takashi Nakada, Sumie Muramatsu, Tomoko Shibutani, Tomoyo Honda, Tomomichi Fujitani, Reiko Kamei, Michiko Kitamura, Junko Yamaguchi, Tadashi Toki, Tetsuo Aida, Ken Sakurai, Tsuyoshi Karibe, Takanori Maejima, Satoru Yasuda, Daisuke Okajima
Supplementary Data from Datopotamab Deruxtecan, a Novel TROP2-directed Antibody–drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1858eb2b81f8b7c3ad2bbf1d6159d0
https://doi.org/10.1158/1535-7163.22521904
https://doi.org/10.1158/1535-7163.22521904
Autor:
Toshinori Agatsuma, Yuki Abe, Takashi Nakada, Ichiro Hayakawa, Tetsuo Aida, Tomoko Shibutani, Yumi Nishiya, Akiko Watanabe, Kazuyoshi Kumagai, Chiharu Hattori, Takanori Maejima, Jun Hasegawa, Michiko Yamato
B7-H3 is overexpressed in various solid tumors and has been considered as an attractive target for cancer therapy. Here, we report the development of DS-7300a, a novel B7-H3–targeting antibody–drug conjugate with a potent DNA topoisomerase I inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a31bd9f9c43f7e981e6be14ca30c4b1
https://doi.org/10.1158/1535-7163.c.6543217
https://doi.org/10.1158/1535-7163.c.6543217
Autor:
Michiko Yamato, Jun Hasegawa, Takanori Maejima, Chiharu Hattori, Kazuyoshi Kumagai, Akiko Watanabe, Yumi Nishiya, Tomoko Shibutani, Tetsuo Aida, Ichiro Hayakawa, Takashi Nakada, Yuki Abe, Toshinori Agatsuma
Publikováno v:
Molecular Cancer Therapeutics. 21:635-646
B7-H3 is overexpressed in various solid tumors and has been considered as an attractive target for cancer therapy. Here, we report the development of DS-7300a, a novel B7-H3–targeting antibody–drug conjugate with a potent DNA topoisomerase I inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3759d969aadf128e10d9488ca610c7
https://doi.org/10.1158/1535-7163.mct-21-0554
https://doi.org/10.1158/1535-7163.mct-21-0554
Autor:
Takanori Maejima1, Kazuyoshi Kumagai1 kumagai.kazuyoshi.k6@daiichisankyo.co.jp, Koichi Yabe1, Kyohei Yasuno1, Kayoko Ishikawa1, Keiko Okado2, Noriko Sasaki2, Kiyonori Kai1, Kazuhiko Mori1
Publikováno v:
Journal of Toxicologic Pathology. 2020, Vol. 33 Issue 1, p21-24. 4p.
Autor:
Daisuke Okajima, Satoru Yasuda, Takami Suzuki, Michiko Kitamura, Junko Yamaguchi, Takanori Maejima, Tsuyoshi Karibe, Tadashi Toki, Penny Phillips, Toshinori Agatsuma
Publikováno v:
Cancer Research. 83:2932-2932
Background: Trophoblast cell surface antigen 2 (TROP2) is highly expressed in various epithelial tumors, including non-small cell lung cancer (NSCLC) and triple negative breast cancer (TNBC), and correlates with poor prognosis. Datopotamab deruxtecan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5657bb755ef7276704e9385af76187e0
https://doi.org/10.1158/1538-7445.am2023-2932
https://doi.org/10.1158/1538-7445.am2023-2932
Autor:
Chiharu Kuwata, Takanori Maejima, Shinobu Hakamata, Satoko Yahagi, Toshiki Matsuoka, Yoshimi Tsuchiya
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 112
We previously revealed that insulin-induced severe and long-lasting maternal hypoglycemia in rats caused anophthalmia and microphthalmia in fetuses; however, it remained unclear whether hypoglycemia-induced eye anomalies were developmental retardatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d6cfd24c6c735bd58d5bc111591c35
https://pubmed.ncbi.nlm.nih.gov/35738499
https://pubmed.ncbi.nlm.nih.gov/35738499
Autor:
Koichi Yabe, Kazuhiko Mori, Noriko Sasaki, Kazuyoshi Kumagai, Kayoko Ishikawa, Kiyonori Kai, Takanori Maejima, Keiko Okado, Kyohei Yasuno
Publikováno v:
Journal of Toxicologic Pathology
A 40-week-old male spontaneous diabetic Torii rat, an animal model of type 2 diabetes mellitus, was found to have marked urinary calculi with hematuria in the urinary bladder on necropsy. Histological findings in the urinary bladder included a papill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad40e116032b1f5f932f4ac3918812d
https://doi.org/10.1293/tox.2019-0057
https://doi.org/10.1293/tox.2019-0057
Autor:
Miki Yamaguchi, Reiko Kamei, Ken Sakurai, Tsuyoshi Karibe, Satoru Yasuda, Michiko Kitamura, Daisuke Okajima, Toshinori Agatsuma, Shu Takahashi, Tetsuo Aida, Sumie Muramatsu, Tomomichi Fujitani, Junko Yamaguchi, Hirofumi Hamada, Yutaka Noguchi, Takashi Nakada, Tomoyo Honda, Takanori Maejima, Masato Murakami, Tomoko Shibutani, Riki Goto, Yuki Abe, Tadashi Toki
Publikováno v:
Molecular cancer therapeutics. 20(12)
Trophoblast cell surface antigen 2 (TROP2) is highly expressed on various epithelial tumors and correlates with poor prognosis. We developed the novel TROP2-directed antibody–drug conjugate (ADC), datopotamab deruxtecan (Dato-DXd, DS-1062a), with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90ecc9437d6afefc94a4dc176e9af3d
https://pubmed.ncbi.nlm.nih.gov/34413126
https://pubmed.ncbi.nlm.nih.gov/34413126
Autor:
Reiko Kamei, Daisuke Okajima, Yuki Abe, Tomoko Shibutani, Tomomichi Fujitani, Junko Yamaguchi, Takashi Nakada, Toshinori Agatsuma, Takanori Maejima, Riki Goto, Tadashi Toki, Tsuyoshi Karibe, Yutaka Noguchi, Michiko Kitamura, Satoru Yasuda
Publikováno v:
Molecular Cancer Therapeutics. 18:C026-C026
Background: A trophoblast cell surface antigen 2 (TROP2) is a 36-kDa single-pass transmembrane protein overexpressed in various epithelial tumors including non-small cell lung cancer (NSCLC) with relatively low and restricted expression in normal tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e64148ac06d2c67a0618f656f13c1f6
https://doi.org/10.1158/1535-7163.targ-19-c026
https://doi.org/10.1158/1535-7163.targ-19-c026