Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Takanobu Kobayashi"'
Autor:
Taishu Kawada, Katsuhito Kino, Kyousuke Tokorodani, Ryuto Anabuki, Masayuki Morikawa, Takanobu Kobayashi, Kazuaki Ohara, Takayuki Ohshima, Hiroshi Miyazawa
Publikováno v:
Genes and Environment, Vol 44, Iss 1, Pp 1-8 (2022)
Abstract Urea (Ua) is produced in DNA as the result of oxidative damage to thymine and guanine. It was previously reported that Klenow fragment (Kf) exo− incorporated dATP opposite Ua, and that DNA polymerase β was blocked by Ua. We report here th
Externí odkaz:
https://doaj.org/article/f70cd6ac609e4fbc91bb357755f3599f
Autor:
Taishu Kawada, Katsuhito Kino, Yoshihiko Matsuzawa, Masayuki Morikawa, Yasuko Okamoto, Takanobu Kobayashi, Yoshiyuki Tanaka
Publikováno v:
Molbank, Vol 2022, Iss 3, p M1436 (2022)
The title compound, N′1,N′4-bis(2-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethylidene)succinohydrazide (1), was obtained by the reaction of formylmethylflavin and succinic acid dihydrazide. The product 1 was characterized by
Externí odkaz:
https://doaj.org/article/d6d52cf689e34e098e46879a776a2dc8
Autor:
Katsuhito Kino, Takayuki Ohshima, Hajime Takeuchi, Takanobu Kobayashi, Taishu Kawada, Masayuki Morikawa, Hiroshi Miyazawa
Publikováno v:
Challenges, Vol 12, Iss 2, p 33 (2021)
The linear no-threshold (LNT) theory describes the linear relationship between a radiation dose and its effects. However, whether the linear relationship is maintained at low radiation doses has yet to be determined. Many previous studies support the
Externí odkaz:
https://doaj.org/article/68d8f8eb12b341808e592a00db9ae84a
Publikováno v:
Molecules, Vol 19, Iss 8, Pp 11030-11044 (2014)
DNA is constantly being oxidized, and oxidized DNA is prone to mutation; moreover, guanine is highly sensitive to several oxidative stressors. Several oxidatively damaged forms of guanine—including 2,2,4-triamino-5(2H)-oxazolone (Oz), iminoallantoi
Externí odkaz:
https://doaj.org/article/1e04d8a19075407999f0944220558634
Autor:
Masayuki Morikawa, Katsuhito Kino, Takeshi Senda, Masayo Suzuki, Takanobu Kobayashi, Hiroshi Miyazawa
Publikováno v:
Molecules, Vol 19, Iss 7, Pp 9552-9561 (2014)
In a previous study, we showed that formylmethylflavin (FMF) can bind to cysteine. In this study, FMF was reacted with native peptides (CG and CKLVFF) containing an N-terminal cysteine. The formation of flavin-CG and flavin-CKLVFF was confirmed using
Externí odkaz:
https://doaj.org/article/a88700b218cc43869acbab03920e6acd
Autor:
Hiroshi Miyazawa, Rie Komori, Takanobu Kobayashi, Katsuhito Kino, Masayuki Morikawa, Masayo Suzuki
Publikováno v:
Molecules, Vol 17, Iss 6, Pp 6705-6715 (2012)
DNA is constantly exposed to endogenous and exogenous oxidative stresses. Damaged DNA can cause mutations, which may increase the risk of developing cancer and other diseases. G:C-C:G transversions are caused by various oxidative stresses. 2,2,4-Tria
Externí odkaz:
https://doaj.org/article/b6ffe5e09fbf4f9da33a17ee52856ad5
Autor:
Masayuki Morikawa, Katsuhito Kino, Eriko Asada, Kosuke Katagiri, Kanami Mori-Yasumoto, Masayo Suzuki, Takanobu Kobayashi, Hiroshi Miyazawa
Publikováno v:
Molbank, Vol 2014, Iss 4, p M836 (2014)
The title compound, N'-[2-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin- 10(2H)-yl)ethylidene]-4-nitrobenzohydrazide (1), was obtained by the reaction of formylmethylflavin and p-nitrobenzohydrazide. The product 1 inhibited the DNA binding of n
Externí odkaz:
https://doaj.org/article/eef591643a2f43df8b73cd43f93ec5d3
Autor:
Masayo Suzuki, Kazuya Ohtsuki, Katsuhito Kino, Teruhiko Kobayashi, Masayuki Morikawa, Takanobu Kobayashi, Hiroshi Miyazawa
Publikováno v:
Journal of Nucleic Acids, Vol 2014 (2014)
Externí odkaz:
https://doaj.org/article/8562839eecad4103b3540d6b39486ac1
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61938 (2013)
κ-Casein (CSN3) is known to play an essential role in controlling the stability of the milk micelles. We found that the expression of Csn3 was induced by all-trans retinoic acid (ATRA) during neural differentiation in P19 embryonal carcinoma cells f
Externí odkaz:
https://doaj.org/article/78cf5d35a2844b9f88cdaa887aa6beb4
Autor:
Taishu Kawada, Katsuhito Kino, Kyousuke Tokorodani, Ryuto Anabuki, Masayuki Morikawa, Takanobu Kobayashi, Kazuaki Ohara, Takayuki Ohshima, Hiroshi Miyazawa
Publikováno v:
Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 44(1)
Abstract Urea (Ua) is produced in DNA as the result of oxidative damage to thymine and guanine. It was previously reported that Klenow fragment (Kf) exo− incorporated dATP opposite Ua, and that DNA polymerase β was blocked by Ua. We report here th