Výsledky vyhledávání - "Takanao Otsuka"

Akademický článek

Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K

Autor: Shun Sato, Kana Yamamoto, Moeno Ito, Katsutoshi Nishino, Takanao Otsuka, Kazuhiro Irie, Masaya Nagao

Publikováno v: Molecules, Vol 28, Iss 10, p 4197 (2023)

Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed. Recently, allosteric inhibitors with high specificity and few side effects have been at

Externí odkaz: https://doaj.org/article/c3309eb4348e4b84b3a4d29c2794a80d

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Mutagenicity and clastogenicity of extracts of Helicobacter pylori detected by the Ames test and in the micronucleus test using human lymphoblastoid cells

Autor: Takeshi Ishikawa, Kaori Ohta, Keinosuke Okamoto, Tomoe Negishi, Keiji Oguma, Takanao Otsuka, Yuta Yuhara, Sakae Arimoto-Kobayashi, Yoshihiro Nakajima, Yuka Ayabe

Publikováno v: Mutagenesis. 30:537-544

Epidemiological studies have demonstrated a close association between infection with Helicobacter pylori (H.pylori) and the development of gastric carcinoma. Chronic H.pylori infection increases the frequency of mutation in gastric epithelial cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c3c56835df5dc189789b1900e2da77
https://doi.org/10.1093/mutage/gev016

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WF14865A and B, New Cathepsins B and L Inhibitors Produced by Aphanoascus fulvescens. I. Taxonomy, Production, Purification and Biological Properties

Autor: Hiroshi Hatanaka, Seiji Hashimoto, Masanori Okamoto, Yuko Muramatsu, Tomoko Nakanishi, Motohiro Hino, Takanao Otsuka

Publikováno v: The Journal of Antibiotics. 53:449-458

WF14865A and B, novel cathepsins B and L inhibitors, were produced and isolated separately from the culture mycelium of a fungal strain Aphanoascus fulvescens No. 14865. Spectroscopic analysis revealed that both WF14865A and B were composed of trans-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6043422c45e2519bd68a186fe025d0a6
https://doi.org/10.7164/antibiotics.53.449

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WF14861, a New Cathepsins B and L Inhibitor Produced by Colletotrichum sp. I. Taxonomy, Production, Purification and Structure lucidation

Autor: Tomoko Nakanishi, Masanori Okamoto, Shigehiro Takase, Seiji Hashimoto, Takanao Otsuka, Yuko Muramatsu, Hiroshi Hatanaka, Motohiro Hino, Tomoji Fujisawa Pharmaceutical Co. Ltd. Higaki

Publikováno v: The Journal of Antibiotics. 52:536-541

WF14861, a novel cathepsins B and L inhibitor, was obtained from the culture mycelium of a fungus strain Colletotrichum sp. No. 14861. Spectroscopic analysis showed that WF14861 consisted of trans-epoxysuccinic acid, L-tyrosine and spermidine, WF1486

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5032df0a96ee9edeaf17b602ff702fc8
https://doi.org/10.7164/antibiotics.52.536

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WA8242A1, A2 and B, Novel Secretary Phospholipase A2 Inhibitors Produced by Streptomyces violaeeusniger. III. Structure Elucidation and Total Synthesis of WA8242B

Autor: Keiji Hemmi, Seiji Yoshimura, Takanao Otsuka, Shigehiro Takase, Masanori Okamoto, Okada Satoshi

Publikováno v: The Journal of Antibiotics. 51:655-664

The structure of WA8242B, a potent novel inhibitor against phospholipase A2, was fully characterized by spectroscopic methods and chemical degradation. The success of total synthesis of WA8242B confirmed the structure and allowed the pharmacological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4c9c76c90af30b3c51f2258a16171b
https://doi.org/10.7164/antibiotics.51.655

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WA8242A1, A2 and B, Novel Secretory Phospholipase A2 Inhibitors Produced by Streptomyces violaceusniger. I. Taxonomy, Production and Purification

Autor: Masanori Okamoto, Yasuhisa Tsurumi, Masakuni Okuhara, Seiji Yoshimura, Yuko Muramatsu, Takanao Otsuka, Hiroshi Hatanaka, Seiji Hashimoto

Publikováno v: The Journal of Antibiotics. 51:1-7

WA8242A1, A2 and B, novel inhibitors of secretory phospholipase A2, were obtained from the cultured mycelium of Streptomyces violaceusniger No. 8242. WA8242A1, A2 and B are structurally related compounds with α-aminoadipic acid and with various leng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b3cf080327c80ec031e24aafecfff6
https://doi.org/10.7164/antibiotics.51.1

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