Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Takamitsu Unoki"'
Autor:
Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, Motohiro Nishida, Yoshito Kumagai
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102514- (2022)
Reactive sulfur species (RSS) play a role in redox homeostasis; however, adaptive cell responses to excessive intracellular RSS are not well understood. Therefore, in this study, we generated transgenic (Tg) mice overexpressing cystathionine gamma-ly
Externí odkaz:
https://doaj.org/article/ef3f1e3c976a479486f613b7e183028e
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Electrophiles can activate redox signal transduction pathways, through actions of effector molecules (e.g., kinases and transcription factors) and sensor proteins with low pKa thiols that are covalently modified. In this study, we investigat
Externí odkaz:
https://doaj.org/article/ca50ba0bba66421e93d7839da990216f
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 545 (2020)
Molecular responses mediated by sensor proteins are important for biological defense against electrophilic stresses, such as xenobiotic electrophile exposure. NF-E2-related factor 2 (Nrf2) has an essential function as a master regulator of such cytop
Externí odkaz:
https://doaj.org/article/8640166fbc6e41efbd673e0e44c50811
Autor:
Takamitsu Unoki, Masahiro Akiyama, Yoshito Kumagai, Filipe Marques Gonçalves, Marcelo Farina, João Batista Teixeira da Rocha, Michael Aschner
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Methylmercury (MeHg) is a potent neurotoxin that affects particularly the developing brain. Since MeHg is a potent electrophilic agent, a wide range of intracellular effects occur in response to its exposure. Yet, the molecular mechanisms associated
Externí odkaz:
https://doaj.org/article/c0896443ab0a4ad8bf03de8846cffb90
Autor:
Masatake Fujimura1 MASATAKE_FUJIMURA@env.go.jp, Takamitsu Unoki1
Publikováno v:
Journal of Toxicological Sciences. May2022, Vol. 47 Issue 5, p211-219. 9p.
Autor:
Takamitsu Unoki1 TAKAMITSU_UNOKI@env.go.jp, Masahiro Akiyama2, Yasuhiro Shinkai3, Yoshito Kumagai3, Masatake Fujimura1
Publikováno v:
Journal of Toxicological Sciences. Jan2022, Vol. 47 Issue 1, p31-37. 7p.
Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide
Publikováno v:
Fundamental Toxicological Sciences. 7:161-166
Autor:
Masahiro Akiyama1, Takamitsu Unoki1,2, Yasuhiro Shinkai1, Isao Ishii3, Tomoaki Ida4, Takaaki Akaike4, Masayuki Yamamoto5, Yoshito Kumagai1 yk-em-tu@md.tsukuba.ac.jp
Publikováno v:
Environmental Health Perspectives. Jun2019, Vol. 127 Issue 6, p1-11. 11p. 2 Diagrams, 2 Charts, 4 Graphs.
Autor:
Sawako Horai, Yumi Abiko, Takamitsu Unoki, Yasuhiro Shinkai, Masahiro Akiyama, Katsushi Nakata, Tatsuya Kunisue, Yoshito Kumagai
Publikováno v:
Chemosphere. 295
Reactive sulfur species (RSS), such as hydrogen per (poly)sulfide, cysteine per (poly)sulfide, glutathione per (poly)sulfide, and protein-bound per (poly)sulfides, can easily react with environmental electrophiles such as methylmercury (MeHg), becaus
Publikováno v:
Toxicological Research
We are exposed to numerous xenobiotic electrophiles on a daily basis through the environment, lifestyle, and dietary habits. Although such reactive species have been associated with detrimental effects, recent accumulated evidence indicates that xeno