Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Takamitsu Sasaki"'
Autor:
Yoshihiro Miyagawa, Rina Fujiwara-Tani, Ayaka Ikemoto, Rika Sasaki, Ruiko Ogata, Yukiko Nishiguchi, Kei Goto, Isao Kawahara, Takamitsu Sasaki, Hiroki Kuniyasu
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 6472-6488 (2024)
β-Casomorphin-7 (BCM), a breakdown product of milk β-casein, exhibits opioid activity. Opioids are known to affect the immune system, but the effects of BCM on ulcerative colitis (UC) are not clear. We examined the effects of BCM on mucosal immunit
Externí odkaz:
https://doaj.org/article/33a1b6fc90d446aa9c5686fbe5c209e4
Autor:
Ryoichi Nishida, Shota Nukaga, Isao Kawahara, Yoshihiro Miyagawa, Kei Goto, Chie Nakashima, Yi Luo, Takamitsu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Ruiko Ogata, Shiori Mori, Rina Fujiwara-Tani, Hiroki Kuniyasu
Publikováno v:
Antioxidants, Vol 13, Iss 7, p 821 (2024)
Nutritional interventions are one focus of sarcopenia treatment. As medium-chain fatty acids (MCFAs) are oxidized in the mitochondria and produce energy through oxidative phosphorylation (OXPHOS), they are key parts of nutritional interventions. We i
Externí odkaz:
https://doaj.org/article/e04b54b1bf75479ba11f32cf826be786
Autor:
Yi Luo, Rina Fujiwara-Tani, Isao Kawahara, Kei Goto, Shota Nukaga, Ryoichi Nishida, Chie Nakashima, Takamitsu Sasaki, Yoshihiro Miyagawa, Ruiko Ogata, Kiyomu Fujii, Hitoshi Ohmori, Hiroki Kuniyasu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7060 (2024)
Skeletal muscle aging and sarcopenia result in similar changes in the levels of aging markers. However, few studies have examined cancer sarcopenia from the perspective of aging. Therefore, this study investigated aging in cancer sarcopenia and explo
Externí odkaz:
https://doaj.org/article/b198df5bce11409a87fcbbad2746acc6
Autor:
Takamitsu Sasaki, Rina Fujiwara-Tani, Yi Luo, Ruiko Ogata, Rika Sasaki, Ayaka Ikemoto, Yukiko Nishiguchi, Chie Nakashima, Shingo Kishi, Kiyomu Fujii, Hitoshi Ohmori, Naohide Oue, Hiroki Kuniyasu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6846 (2024)
Abnormalities in mucosal immunity are involved in the onset and progression of ulcerative colitis (UC), resulting in a high incidence of colorectal cancer (CRC). While high-mobility group box-1 (HMGB1) is overexpressed during colorectal carcinogenesi
Externí odkaz:
https://doaj.org/article/1e3363881e3d4234ac6855562f05c979
Autor:
Rina Fujiwara-Tani, Takamitsu Sasaki, Ujjal Kumar Bhawal, Shiori Mori, Ruiko Ogata, Rika Sasaki, Ayaka Ikemoto, Shingo Kishi, Kiyomu Fujii, Hitoshi Ohmori, Masayuki Sho, Hiroki Kuniyasu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 4056 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is highly malignant, with a 5-year survival rate of less than 10%. Furthermore, the acquisition of anticancer drug resistance makes PDAC treatment difficult. We established MIA-GEM cells, a PDAC cell line resis
Externí odkaz:
https://doaj.org/article/b57a0d82bb234122bd2dda9360a51763
Autor:
Kiyomu Fujii, Rina Fujiwara-Tani, Shota Nukaga, Hitoshi Ohmori, Yi Luo, Ryoichi Nishida, Takamitsu Sasaki, Yoshihiro Miyagawa, Chie Nakashima, Isao Kawahara, Ruiko Ogata, Ayaka Ikemoto, Rika Sasaki, Hiroki Kuniyasu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 3015 (2024)
Patients with cancer die from cardiac dysfunction second only to the disease itself. Cardiotoxicity caused by anticancer drugs has been emphasized as a possible cause; however, the details remain unclear. To investigate this mechanism, we treated rat
Externí odkaz:
https://doaj.org/article/499f30265ecb4415ac43fd9caf3cf384
Autor:
Shingo Kishi, Shiori Mori, Rina Fujiwara-Tani, Ruiko Ogata, Rika Sasaki, Ayaka Ikemoto, Kei Goto, Takamitsu Sasaki, Makito Miyake, Satoru Sasagawa, Masashi Kawaichi, Yi Luo, Ujjal Kumar Bhawal, Kiyohide Fujimoto, Hidemitsu Nakagawa, Hiroki Kuniyasu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16367 (2023)
N-methyl-glycine (sarcosine) is known to promote metastatic potential in some cancers; however, its effects on bladder cancer are unclear. T24 cells derived from invasive cancer highly expressed GNMT, and S-adenosyl methionine (SAM) treatment increas
Externí odkaz:
https://doaj.org/article/607bbfb552ad4f5b93eb5a1e83c8f4c4
Autor:
Tadataka Takagi, Rina Fujiwara-Tani, Shiori Mori, Shingo Kishi, Yukiko Nishiguchi, Takamitsu Sasaki, Ruiko Ogata, Ayaka Ikemoto, Rika Sasaki, Hitoshi Ohmori, Yi Luo, Ujjal Kumar Bhawal, Masayuki Sho, Hiroki Kuniyasu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7506 (2023)
Although gemcitabine (GEM) is widely used in chemotherapy for pancreatic ductal adenocarcinoma (PDA), drug resistance restricts its clinical effectiveness. To examine the mechanism of GEM resistance, we established two GEM-resistant cell lines from h
Externí odkaz:
https://doaj.org/article/1cc8e2667b7b49d69d2d9ddd229f5ef2
Autor:
Rina Fujiwara-Tani, Tadataka Takagi, Shiori Mori, Shingo Kishi, Yukiko Nishiguchi, Takamitsu Sasaki, Masayuki Ikeda, Kenta Nagai, Ujjal Kumar Bhawal, Hitoshi Ohmori, Kiyomu Fujii, Hiroki Kuniyasu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3182 (2023)
Gastric cancers are strongly associated with Helicobacter pylori infection, with intestinal metaplasia characterizing the background mucosa in most cases. However, only a subset of intestinal metaplasia cases proceed to carcinogenesis, and the charac
Externí odkaz:
https://doaj.org/article/545e2232da61482186680567961b9cd8
Autor:
Takamitsu Sasaki, Rina Fujiwara‐Tani, Shingo Kishi, Shiori Mori, Yi Luo, Hitoshi Ohmori, Isao Kawahara, Kei Goto, Yukiko Nishiguchi, Takuya Mori, Masayuki Sho, Masuo Kondo, Hiroki Kuniyasu
Publikováno v:
Cancer Medicine, Vol 8, Iss 15, Pp 6700-6708 (2019)
Abstract Claudin (CLDN) family comprises of protein that form a tight junction, and is involved in regulating polarity and differentiation of cells. Here, we aimed to investigate the effects of inhibiting CLDN4 in pancreatic ductal carcinomas (PDC).
Externí odkaz:
https://doaj.org/article/f44780c7755b405b8bed9c7cfacb653f