Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Takamasa Inoue"'
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008946 (2020)
During internalization and trafficking, human papillomavirus (HPV) moves from the cell surface to the endosome where the transmembrane protease γ-secretase promotes insertion of the viral L2 capsid protein into the endosome membrane. Protrusion of L
Externí odkaz:
https://doaj.org/article/cb5e683e26f2456a95b50f81d48c1a17
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1666-1674.e4 (2019)
Summary: Although flaviviruses co-opt the function of the host endoplasmic reticulum (ER) membrane protein complex (EMC) during infection, a mechanistic explanation for this observation remains unclear. Here, we show that the EMC promotes biogenesis
Externí odkaz:
https://doaj.org/article/9febe1d429c84cf6855fe93b9a37b6de
Autor:
Masaaki Kawano, Koji Doi, Hajime Fukuda, Yoshinori Kita, Kensuke Imai, Takamasa Inoue, Teruya Enomoto, Masanori Matsui, Mamoru Hatakeyama, Yuki Yamaguchi, Hiroshi Handa
Publikováno v:
Biotechnology Reports, Vol 5, Iss C, Pp 105-111 (2015)
The icosahedral capsid structure of simian virus 40 (diameter, 45 nm) consists of 72 pentameric subunits, with each subunit formed by five VP1 molecules. Electron microscopy, immuno-gold labeling, and ζ-potential analysis showed that purified recomb
Externí odkaz:
https://doaj.org/article/936337dea71f40b8b6e8b0f5a4ccba31
Autor:
Takamasa Inoue, Billy Tsai
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006439 (2017)
The molecular mechanism by which non-enveloped viruses penetrate biological membranes remains enigmatic. The non-enveloped polyomavirus SV40 penetrates the endoplasmic reticulum (ER) membrane to reach the cytosol and cause infection. We previously de
Externí odkaz:
https://doaj.org/article/37f0b0aff2164d88b4327b7c4e191702
Publikováno v:
eLife, Vol 5 (2016)
Destabilization of a non-enveloped virus generates a membrane transport-competent viral particle. Here we probe polyomavirus SV40 endoplasmic reticulum (ER)-to-cytosol membrane transport, a decisive infection step where destabilization initiates this
Externí odkaz:
https://doaj.org/article/b13cebe98eb740969f48b4f75b052d7f
Publikováno v:
PLoS Pathogens, Vol 11, Iss 8, p e1005086 (2015)
Mammalian cytosolic Hsp110 family, in concert with the Hsc70:J-protein complex, functions as a disaggregation machinery to rectify protein misfolding problems. Here we uncover a novel role of this machinery in driving membrane translocation during vi
Externí odkaz:
https://doaj.org/article/eee4f726b8d0478492c0e3e34d574789
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1004007 (2014)
Nonenveloped viruses undergo conformational changes that enable them to bind to, disrupt, and penetrate a biological membrane leading to successful infection. We assessed whether cytosolic factors play any role in the endoplasmic reticulum (ER) membr
Externí odkaz:
https://doaj.org/article/5a8dedd692a84b64a0ae26292431fbd2
Autor:
Edward C. Goodwin, Alex Lipovsky, Takamasa Inoue, Thomas G. Magaldi, Anne P. B. Edwards, Kristin E. Y. Van Goor, Adrienne W. Paton, James C. Paton, Walter J. Atwood, Billy Tsai, Daniel DiMaio
Publikováno v:
mBio, Vol 2, Iss 3 (2011)
ABSTRACT Simian virus 40 (SV40) is a nonenveloped DNA virus that traffics through the endoplasmic reticulum (ER) en route to the nucleus, but the mechanisms of capsid disassembly and ER exit are poorly understood. We conducted an unbiased RNA interfe
Externí odkaz:
https://doaj.org/article/7d5ff50acbcd43f9ac63ba8b338523b9
Autor:
Takamasa Inoue, Billy Tsai
Publikováno v:
PLoS Pathogens, Vol 7, Iss 5, p e1002037 (2011)
Non-enveloped viruses penetrate host membranes to infect cells. A cell-based assay was used to probe the endoplasmic reticulum (ER)-to-cytosol membrane transport of the non-enveloped SV40. We found that, upon ER arrival, SV40 is released into the lum
Externí odkaz:
https://doaj.org/article/962b6071a809416c8cf2fe122e6a7d0a
Publikováno v:
Transfusion. 61:2514-2515