Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Takako Makita"'
Autor:
Ruolan Song, Hirofumi Watanabe, Kelsey Tjen, Baylee C. Westbury, Takako Makita, Ge Tao, Henry M. Sucov
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Mammalian cardiomyocytes (CMs) mostly become polyploid shortly after birth. Because this feature may relate to several aspects of heart biology, including regeneration after injury, the mechanisms that cause polyploidy are of interest. BALB/
Externí odkaz:
https://doaj.org/article/9132e3360304417d9d6320ad19f42e46
Autor:
Hirofumi Watanabe, Ge Tao, Peiheng Gan, Baylee C. Westbury, Kristie D. Cox, Kelsey Tjen, Ruolan Song, Glenn I. Fishman, Takako Makita, Henry M. Sucov
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 10, Iss 4, p 161 (2023)
Adult hearts are characterized by inefficient regeneration after injury, thus, the features that support or prevent cardiomyocyte (CM) proliferation are important to clarify. Diploid CMs are a candidate cell type that may have unique proliferative an
Externí odkaz:
https://doaj.org/article/d8d4c517d1e44ae3b2d7f98118750785
Autor:
Peiheng Gan, Michaela Patterson, Alexa Velasquez, Kristy Wang, Di Tian, Jolene J Windle, Ge Tao, Daniel P Judge, Takako Makita, Thomas J Park, Henry M Sucov
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008354 (2019)
Recent evidence implicates mononuclear diploid cardiomyocytes as a proliferative and regenerative subpopulation of the postnatal heart. The number of these cardiomyocytes is a complex trait showing substantial natural variation among inbred mouse str
Externí odkaz:
https://doaj.org/article/b0cd004e06be40bea92e5a2d3d6387fa
Autor:
Denise M Poltavski, Pauline Colombier, Jianxin Hu, Alicia Duron, Brian L Black, Takako Makita
Publikováno v:
eLife, Vol 8 (2019)
Developing neurons of the peripheral nervous system reach their targets via cues that support directional growth, a process known as axon guidance. In investigating how sympathetic axons reach the heart in mice, we discovered that a combination of gu
Externí odkaz:
https://doaj.org/article/5ffb01bfc1334249b1b871f78abba559
Autor:
Matthew J Jansen, Letitia L Williams, Sophie Wang, Elizabeth M Eultgen, Keigo Takahashi, Hemanth R Nelvagal, Jaiprakash Sharma, Marco Sardiello, Brian J DeBosch, Jessica B Anderson, Sophie E Sax, Christina M Wright, Takako Makita, John R Grider, Mark S Sands, Robert Heuckeroth, Jonathan D Cooper
Background and aims: Children with neurodegenerative disease often have debilitating gastrointestinal (GI) symptoms that may be due at least in part to underappreciated involvement of neurons in the enteric nervous system (ENS), the master regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4272837d82d1e0c66824ab959beca063
https://doi.org/10.1101/2023.05.26.542524
https://doi.org/10.1101/2023.05.26.542524
Purkinje cardiomyocytes of the ventricular conduction system are highly diploid but not regenerative
Autor:
Hirofumi Watanabe, Ge Tao, Peiheng Gan, Baylee C. Westbury, Kristie D. Cox, Kelsey Tjen, Ruolan Song, Glenn I. Fishman, Takako Makita, Henry M. Sucov
Inefficiency of regeneration underlies many of the pathologies associated with heart injury and disease. Ventricular diploid cardiomyocytes (CMs) are a candidate population that may have enhanced proliferative and regenerative properties [1-3], but s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::034bc01b1947604d2b73a28556383254
https://doi.org/10.1101/2022.10.29.514354
https://doi.org/10.1101/2022.10.29.514354
Autor:
Peiheng Gan, Takako Makita, Henry M. Sucov, Ge Tao, Hirofumi Watanabe, Rupak Mukherjee, Daniel P. Judge, Catalin F. Baicu, Kristy Wang, Michael R. Zile
Publikováno v:
Hum Mol Genet
TNNI3K expression worsens disease progression in several mouse heart pathology models. TNNI3K expression also reduces the number of diploid cardiomyocytes, which may be detrimental to adult heart regeneration. However, the gene is evolutionarily cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a03983869d3d424183096d9d6ba92d
https://doi.org/10.1093/hmg/ddaa234
https://doi.org/10.1093/hmg/ddaa234
Autor:
Jonathan D. Cooper, Sophie H. Wang, Letitia L. Williams, Elizabeth M. Eultgen, Keigo Takahashi, Hemanth R. Nelvagal, Jessica B. Anderson, Takako Makita, Brian DeBosch, Mark S. Sands, Robert O. Heuckeroth
Publikováno v:
Molecular Genetics and Metabolism. 135:S33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98533238c7f00c0c0b104c596b7fc22e
https://doi.org/10.1016/j.ymgme.2021.11.071
https://doi.org/10.1016/j.ymgme.2021.11.071
Autor:
Takako Makita, Jianxin Hu, Denise M Poltavski, Alicia Duron, Brian L. Black, Pauline Colombier
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Developing neurons of the peripheral nervous system reach their targets via cues that support directional growth, a process known as axon guidance. In investigating how sympathetic axons reach the heart in mice, we discovered that a combination of gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e573d0437ed7a3b3688a25d1caacfcc0
https://pubmed.ncbi.nlm.nih.gov/30735130
https://pubmed.ncbi.nlm.nih.gov/30735130