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NSAID, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4+VEGFR1+ cells to the ulcer granulation tissues

Autor: Masataka Majima, Takehito Sato, Takako Ae, Takashi Ohno, Yoshiya Ito, Koji Eshima, Hideki Amano, Chikatoshi Katada, Tsutomu Minamino, Kanako Hosono, Wasaburo Koizumi, Tatsunori Suzuki, Masabumi Shibuya

Publikováno v: Biomedicine & Pharmacotherapy. 67:607-613

Background Ulcer healing is a complex process, which involves cell migration, proliferation, angiogenesis and re-epithelialization. Several growth factors have been implicated in this process but the precise mechanism is not well understood. This stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f32531ec332ee35b4e82f6ca9cba9c
https://doi.org/10.1016/j.biopha.2013.01.009

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Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+CXCR4+ cells recruited from bone marrow

Autor: Wasaburo Koizumi, Takehito Sato, Tsutomu Minamino, Hideki Amano, Chikatoshi Katada, Kanako Hosono, Masataka Majima, Takashi Ohno, Takako Ae, Masabumi Shibuya, Koji Eshima, Yoshiya Ito, Tatsunori Suzuki

Publikováno v: Journal of Gastroenterology. 49:455-469

Angiogenesis is essential for gastric ulcer healing. Recent results suggest that vascular endothelial growth factor receptor 1 (VEGFR1), which binds to VEGF, promotes angiogenesis. In the present study, we investigated the role of VEGFR1 signaling in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea0b94a4465ae6e2a04fa0afbf12f8f
https://doi.org/10.1007/s00535-013-0869-z

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A multicenter phase II study of combined chemotherapy with docetaxel, cisplatin, and S-1 in patients with unresectable or recurrent gastric cancer (KDOG 0601)

Autor: Kento Nakatani, Kenji Ishido, Ken Nishimura, Seiichi Takagi, Satoshi Tanabe, Tohru Sasaki, Norisuke Nakayama, Takako Ae, Mizutomo Azuma, Akira Naruke, Chikatoshi Katada, Katsuhiko Higuchi, Wasaburo Koizumi

Publikováno v: Cancer Chemotherapy and Pharmacology. 69:407-413

We conducted a phase II study to evaluate the efficacy and safety of a triplet regimen of docetaxel, cisplatin, and S-1 in patients with unresectable or recurrent gastric cancer.Docetaxel (40 mg/m(2)) and cisplatin (70 or 60 mg/m(2)) were given on da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688ad55c9a99023d9c9369f695cc8765
https://doi.org/10.1007/s00280-011-1701-1

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Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying

Autor: Takehito Satoh, Katsunori Saigenji, Sumito Mizuguchi, Katsuharu Arai, Youichiro Hattori, Izumi Hayashi, Takashi Ohno, Yukihiko Sugimoto, Takeo Saeki, Shuh Narumiya, Tsutomu Minamino, Masataka Majima, Takako Ae

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G1078-G1086

It is widely accepted that the inhibition of gastric motor activity as well as the maintenance of gastric mucosal blood flow and mucous secretion are important for the homeostasis of the gastric mucosa. The present study was performed to ascertain wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f004f58f7c32ba12e608ff75fd2c96bd
https://doi.org/10.1152/ajpgi.00524.2009

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Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study)

Autor: Kenji Ishido, S. Tanabe, K. Saigenji, Wasaburou Koizumi, Mizutomo Azuma, Takako Ae, Chikatoshi Katada, Toru Sasaki, Ken Nishimura, Kento Nakatani, Norisuke Nakayama, Katsuhiko Higuchi

Publikováno v: Journal of Clinical Pharmacy and Therapeutics. 35:303-307

Summary Background and object: An antiulcer agent, ecabet sodium, is active against Helicobacter pylori. The aim of the present study was to clinically examine whether eradication therapy, which includes ecabet sodium, is effective in eradication of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a11f67cc51bd766a64c9e395403722a4
https://doi.org/10.1111/j.1365-2710.2009.01092.x

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Gastric mucosal protection against ethanol by EP2and EP4signaling through the inhibition of leukotriene C4production

Autor: Masataka Majima, Takako Ae, Takashi Ohno, Youichiro Hattori, Katsuharu Arai, Takeo Saeki, Katsunori Saigenji, Sumito Mizuguchi

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 294:G80-G87

Prostaglandin (PG)E derivatives are widely used for treating gastric mucosal injury. PGE receptors are classified into four subtypes, EP1, EP2, EP3, and EP4. We have tested which EP receptor subtypes participate in gastric mucosal protection against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224fd54a03a1c3e6084f200488f27a0b
https://doi.org/10.1152/ajpgi.00292.2007

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BCL-6-positive Human Herpesvirus 8-associated Solid Lymphoma Arising from Liver and Spleen as Multiple Nodular Lesions

Autor: Harutaka Katano, Takako Ae, Hideki Hasegawa, Shigeru Masuo, Yuko Sato, Tetsutaro Sata, Hidehiro Takahashi, Takuya Iwasaki, Masataka Tanno, Takeshi Kurata

Publikováno v: Leukemia & Lymphoma. 45:2169-2172

We report a case of BCL-6-positive B cell lymphoma with human herpesvirus 8 (HHV-8) infection. A human immunodeficiency virus-infected patient developed a diffuse large B cell lymphoma, which was found exclusively in the liver and spleen with the abs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee0c240b0dc954a4f545249a883988c
https://doi.org/10.1080/10428190410001723241

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Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment

Autor: Tsutomu Minamino, Yoshiya Ito, Tatsunori Suzuki, Kanako Hosono, Masataka Majima, Akitaka Shibuya, Hirotoki Ohkubo, Takako Ae, Wasaburo Koizumi, Shuh Narumiya, Hiroyuki Sakagami, Takehito Sato

Publikováno v: Toxicology and applied pharmacology. 259(1)

It is thought that thromboxane A(2) (TxA(2)) contributes to the progression of inflammation during acute hepatic injury; however, it is still unknown whether TxA(2) is involved in liver repair. The objective of the present study was to examine the ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a701f07df173f77f9ee60f331b5489
https://pubmed.ncbi.nlm.nih.gov/22206755

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Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers

Autor: Takehito Sato, Takashi Ohno, Shizuo Akira, Tatsunori Suzuki, Youichiro Hattori, Kanako Hosono, Wasaburo Koizumi, Tsutomu Minamino, Satoshi Uematsu, Masataka Majima, Takako Ae

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology. 299(5)

The importance of prostaglandin E2 in various pathophysiological events emphasizes the necessity of understanding the role of PGE synthases (PGESs) in vivo. However, there has been no report on the functional relevance of microsomal PGES-1 (mPGES-1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515107d1e7f66acf93eec6f105db6ebc
https://pubmed.ncbi.nlm.nih.gov/20813913

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