Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Takaki Seki"'
Autor:
Tadashi Tsubouchi, Shinji Tsujimoto, Shinichi Sugimoto, Yasunori Katsura, Terumasa Mino, Takaki Seki
Publikováno v:
Journal of Pharmacological Sciences, Vol 106, Iss 3, Pp 452-459 (2008)
In this study, the effects of atropine sulfate (atropine) on swallowing and cough reflex were evaluated in the two experimental models in conscious dogs. To evaluate the effects of atropine on swallowing, 1 mL of marker (contrast medium) was injected
Externí odkaz:
https://doaj.org/article/904c6977a0db4fe5b4604c9d81703201
Autor:
Mami Kouchi, Yoshiko Michimae, Takatoshi Koujitani, Hitoshi Funabashi, Tomoaki Tochitani, Takaki Seki, Kaoru Toyosawa, Kazuo Okimoto, Izumi Matsumoto
Publikováno v:
Journal of Toxicologic Pathology
A female congenic rat produced by repeated backcrossing of Nihon rats, a model for hereditary renal cell carcinoma, to Brown Norway rats was necropsied at 24 months of age. At necropsy, a white mass about 1 centimeter in size was observed in the thor
Autor:
Takaki Seki, Tomoaki Tochitani, Mami Kouchi, Izumi Matsumoto, Kaoru Toyosawa, Yoshiko Michimae, Takatoshi Koujitani, Hitoshi Funabashi
Publikováno v:
Journal of Toxicologic Pathology
In the present study, we investigated the histological, immunohistochemical and ultrastructural characteristics of cytoplasmic blood plasma inclusions that spontaneously occurred in a rat liver. Histologically, a number of cytoplasmic inclusions were
Publikováno v:
Regulatory Toxicology and Pharmacology. 58:360-368
The main objective of this study was to evaluate the effects of the antipsychotic drugs haloperidol (HAL) and chlorpromazine (CPZ) on bone mineral density (BMD) in female rats and to examine the relationship between the effects on bone and reproducti
Autor:
Juki Kimura, Kiyoko Bando, Takeshi Kunimatsu, Shoko Ochiai, Jiro Deguchi, Hitoshi Funabashi, Takaki Seki
Publikováno v:
Regulatory Toxicology and Pharmacology. 58:155-160
Lactic acidosis has been considered to be a side effect of some biguanides, after phenformin was withdrawn from the market because of its association with lactic acidosis. The potential of lactic acidosis induced by biguanides at human therapeutic ex
Autor:
Izumi Matsumoto, Kazuo Okimoto, Takaki Seki, Okio Hino, Tadashi Inoue, Tadayoshi Ueda, Kazuyasu Kijima, Mami Kouchi, Youko Hirayama
Publikováno v:
Tumor Biology. 30:249-256
A germline insertion of a single nucleotide in the rat homologue of the human Birt-Hogg-Dubé (BHD) gene gives rise to dominantly inherited renal cell carcinoma (RCC) in the Nihon rat model. In this study, we established 7 lines (NR cell lines NR22,
Autor:
Yoshiko Michimae, Toru Yamada, Toru Kimura, Takaki Seki, Tadashi Inoue, Mami Kouchi, Okio Hino, Masashi Yasuba, Kazuo Okimoto, Izumi Matsumoto
Publikováno v:
Experimental and Toxicologic Pathology. 59:273-279
Fibromatosis-type fibromas were found to develop at abdominal surgical sites in 4 heterozygous Nihon rats, a model for the human Birt–Hogg–Dube syndrome. In all 4 rats, solitary and firm nodules were located within the lateral abdominal musculatu
Autor:
Mami Kouchi, Takatoshi Koujitani, Takaki Seki, Izumi Matsumoto, Shinichi Mikami, Kaoru Toyosawa, Tadashi Inoue, Yoshiko Michimae
Publikováno v:
Journal of Toxicologic Pathology. 21:119-122
An immunohistochemical staining method for prohibitin, a 30-kDa protein located in the inner membrane of mitochondria, is used for detection of mitochondria on formalin-fixed paraffin-embedded sections. Methapyrilene hydrochloride (MP), which is know
Publikováno v:
NeuroToxicology. 27:284-290
Certain kinds of developmental neurotoxicants are considered to act by affecting the levels of thyroid hormones, which are essential for the brain development of both humans and experimental animals. Hypothyroidism experimentally induced in rats with
Autor:
Setsuko Yabushita, Yasuyoshi Okuno, Koichi Saito, Tomoya Yamada, Tokuo Sukata, Shinji Ueda, Takaki Seki, Satoshi Kawamura, Kayo Sumida
Publikováno v:
Toxicology and Applied Pharmacology. 205:11-30
Although benomyl and its metabolite carbendazim have been shown to adversely affect male reproduction, the mechanisms of action do not appear to involve the endocrine system. However, few studies have been conducted using currently proposed tests spe