Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Takaki Komiya"'
Autor:
Tosho Kondo, Ihori Ebinuma, Hirotaka Tanaka, Yukitoshi Nishikawa, Takaki Komiya, Mitsuru Ishikawa, Hideyuki Okano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 6987 (2023)
Amyotrophic lateral sclerosis (ALS) is a major life-threatening disease caused by motor neuron degeneration. More effective treatments through drug discovery are urgently needed. Here, we established an effective high-throughput screening system usin
Externí odkaz:
https://doaj.org/article/66b534a3974b4a22886ea95663fe9487
Autor:
Sanzana Hoque, Yuki Kondo, Nodoka Sakata, Yusei Yamada, Madoka Fukaura, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Katsumi Higaki, Akio Hayashi, Takaki Komiya, Yoichi Ishitsuka, Tetsumi Irie
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 898 (2020)
Niemann−Pick disease type C (NPC) is an autosomal recessive disorder characterized by abnormal accumulation of free cholesterol and sphingolipids in lysosomes. The iminosugar miglustat, which inhibits hexosylceramide synthesis, is used for NPC trea
Externí odkaz:
https://doaj.org/article/ba016d313bf9484d8c68138a937bdff9
Publikováno v:
IEEJ Transactions on Power and Energy. 143:132-138
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:250-260
ONO-4641 is a second-generation sphingosine 1-phosphate (S1P) receptor modulator that exhibits selectivity for S1P receptors 1 and 5. Treatment with ONO-4641 leads to a reduction in magnetic resonance imaging disease measures in patients with relapsi
Autor:
Tomoko Betsuyaku, Makoto Ishii, Hirofumi Kamata, Naoki Hasegawa, Shizuko Kagawa, Ho Namkoong, Takaki Komiya, Shoji Suzuki, Akio Kihara, Ahmed E. Hegab, Sadatomo Tasaka, Satoshi Okamori, Takafumi Hashimoto, Takanori Asakura, Kazuma Yagi
Publikováno v:
Mucosal Immunology. 11:1606-1620
Sphingolipids play a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, little is known about the precise roles of sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, and its receptor modulation
Autor:
Masaharu Komeno, Yuka Takada, Takaki Komiya, Tatsuo Maeda, Haruto Kurata, Ryo Suzuki, Tetsu Kondo, Norikazu Matsunaga, Hiroshi Hagiya, Takeji Ono, Kazuhiro Otsuki, Ken-ici Nunoya, Sachiko Tominaga, Shinji Nakade, Hirotaka Mizuno, Kensuke Kusumi, Hidekazu Kiyoshi, Hiroki Shioya, Masakuni Kurono, Hiromu Habashita
Publikováno v:
Journal of Medicinal Chemistry. 60:9508-9530
The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid 13n (ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P1 and S1P5, is described. Whi
Autor:
Haruto, Kurata, Kensuke, Kusumi, Kazuhiro, Otsuki, Ryo, Suzuki, Masakuni, Kurono, Takaki, Komiya, Hiroshi, Hagiya, Hirotaka, Mizuno, Hiroki, Shioya, Takeji, Ono, Yuka, Takada, Tatsuo, Maeda, Norikazu, Matsunaga, Tetsu, Kondo, Sachiko, Tominaga, Ken-Ici, Nunoya, Hidekazu, Kiyoshi, Masaharu, Komeno, Shinji, Nakade, Hiromu, Habashita
Publikováno v:
Journal of medicinal chemistry. 60(23)
The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid 13n (ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P
Autor:
Takanori, Asakura, Makoto, Ishii, Ho, Namkoong, Shoji, Suzuki, Shizuko, Kagawa, Kazuma, Yagi, Takaki, Komiya, Takafumi, Hashimoto, Satoshi, Okamori, Hirofumi, Kamata, Sadatomo, Tasaka, Akio, Kihara, Ahmed E, Hegab, Naoki, Hasegawa, Tomoko, Betsuyaku
Publikováno v:
Mucosal immunology. 11(6)
Sphingolipids play a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, little is known about the precise roles of sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, and its receptor modulation
Autor:
Masaya Kokubo, Natsuko Tokuda, Kazuhiko Takeda, Tetsuya Sugiyama, Hiromu Habashita, Hiroshi Ochiai, Shiro Shibayama, Noriki Watanabe, Masamichi Imai, Takaki Komiya
Publikováno v:
European Journal of Pharmacology. 720:335-343
CC chemokine receptor 4 (CCR4) has been implicated as a preferential marker for T helper type 2 (Th2) cells, and is believed to be involved in the pathology of allergic diseases by controlling Th2 cell trafficking into inflamed tissues. The objective
Autor:
Zexin Chen, Ruihan Zhang, Hao-Shu Fang, Yu E. Zhang, Aneesh Bal, Haowen Zhou, Rachel R. Rock, Nancy Padilla-Coreano, Laurel R. Keyes, Haoyi Zhu, Yong-Lu Li, Takaki Komiyama, Kay M. Tye, Cewu Lu
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
Computer vision has emerged as a powerful tool to elevate behavioral research. This protocol describes a computer vision machine learning pipeline called AlphaTracker, which has minimal hardware requirements and produces reliable tracking of multiple
Externí odkaz:
https://doaj.org/article/46ba63e31e9349eb9219b04121a340ea