Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Takaichi, Shimozato"'
Autor:
Shigetoshi Sano, Mikiro Takaishi, Takaichi Shimozato, Keisuke Suzuki, Takashi Isobe, Masayuki Ishizaki
Publikováno v:
Journal of Dermatological Science. 85:12-19
Background Targeting the IL-17 pathway represents a highly effective strategy for the treatment of psoriasis, using antibodies against IL-17A and IL-17 receptor, suggesting that Th17 cells essentially contribute to development of psoriasis. Th17 diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744ee876b1c9bd2377aba78c09385935
https://doi.org/10.1016/j.jdermsci.2016.10.001
https://doi.org/10.1016/j.jdermsci.2016.10.001
Autor:
Ryotaku Inoue, Keiko Oshima, Shin-ichi Inaba, Takashi Kagari, Kaoru Tanaka-takanaka, Wataru Tomisato, Takaichi Shimozato, Takashi Izumi, Hiromi Doi-Komuro, Maki Goto, Hiroshi Yuita, Hisako Tanaka
Publikováno v:
Biopharmaceutics & Drug Disposition. 37:561-573
The pharmacokinetic (PK) and pharmacodynamic (PD) modeling was conducted for the reduction of peripheral lymphocytes after oral administration of CS-0777 to healthy rats, monkeys and experimental autoimmune encephalomyelitis (EAE) induced rats. M1, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea3f0a8b833aeadfb8346a8294affc81
https://doi.org/10.1002/bdd.2048
https://doi.org/10.1002/bdd.2048
Autor:
Mamoru Ohtoyo, Takaichi Shimozato, Masakazu Tamura, Katsunobu Hagihara, Jun Watanabe, Jun Chiba, Nobuo Machinaga, Yoshimasa Kobayashi, Yasuo Kita, Miyuki Nagasaki, Koji Abe, Ryuji Hashimoto, Ryotaku Inoue, Fumihito Muro, Hiroshi Yuita
Publikováno v:
Cell Chemical Biology. 23:555-560
Summary Caramel color is widely used in the food industry, and its many variations are generally considered to be safe. It has been known for a long time that THI (2-acetyl-4-(tetrahydroxybutyl)imidazole), a component of caramel color III, causes lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112b01c3b4daf948cd909a82d6c77490
https://doi.org/10.1016/j.chembiol.2016.04.007
https://doi.org/10.1016/j.chembiol.2016.04.007
Autor:
Ikeda Takuya, Toshiyasu Takemoto, Yukiko Sekiguchi, Takashi Kagari, Takaichi Shimozato, Takeshi Fukuda, Taiji Goto, Yumi Kawase, Tsuyoshi Nakamura, Takashi Tsuji, Futoshi Nara, Keisuke Suzuki, Takashi Izumi, Takahide Nishi, Masakazu Tamura, Tomohiro Honda, Shin-ichi Inaba, Takako Kimura, Yumiko Mizuno, Chizuko Yahara
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4246-4256
We report herein the synthesis and structure-activity relationships (SAR) of a series of benzyl ether compounds as an S1P₁ receptor modulator. From our SAR studies, the installation of substituents onto the central benzene ring of 2a was revealed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6618541f0da9c0a0ca160ca5545ee91
https://doi.org/10.1016/j.bmc.2014.05.035
https://doi.org/10.1016/j.bmc.2014.05.035
Autor:
Shin-Ichi, Inaba, Maki, Goto, Kaoru, Tanaka-Takanaka, Hisako, Tanaka, Wataru, Tomisato, Hiroshi, Yuita, Hiromi, Doi-Komuro, Ryotaku, Inoue, Keiko, Oshima, Takashi, Kagari, Takaichi, Shimozato, Takashi, Izumi
Publikováno v:
Biopharmaceuticsdrug disposition. 37(9)
Pharmacokinetic (PK) and pharmacodynamic (PD) modeling was conducted for the reduction of peripheral lymphocytes after oral administration of CS-0777 to healthy rats, monkeys and experimental autoimmune encephalomyelitis (EAE) induced rats. The phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5eda98e35e231eaa795816d8c32c7364
https://pubmed.ncbi.nlm.nih.gov/27764535
https://pubmed.ncbi.nlm.nih.gov/27764535
Autor:
Ryotaku Inoue, Reina Kaneko, Tsuyoshi Nakamura, Hiroshi Yuita, Tetsufumi Koga, Eiko Namba, Hatsumi Nasu, Takahide Nishi, Takashi Kagari, Yukiko Sekiguchi, Yumi Kawase, Kazuhiko Tamaki, Shintaro Nakayama, Keiko Oguchi-Oshima, Takaichi Shimozato, Noriko Masubuchi, Yumiko Mizuno, Masayoshi Asano, Takahiro Yamaguchi, Wataru Tomisato, Futoshi Nara, Hiromi Doi-Komuro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3083-3088
We have previously disclosed 1,2,4-oxadiazole derivative 3 as a potent S1P3-sparing S1P1 agonist. Although compound 3 exhibits potent and manageable immunosuppressive efficacy in various in vivo models, recent studies have revealed that its 1,2,4-oxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dee7d6079550f2c98197e1e96700deda
https://doi.org/10.1016/j.bmcl.2012.03.067
https://doi.org/10.1016/j.bmcl.2012.03.067
Autor:
Hiroshi Yuita, Reina Kaneko, Masayoshi Asano, Takashi Kagari, Takaichi Shimozato, Nobuaki Watanabe, Takahide Nishi, Hiromi Doi, Wataru Tomisato, Takako Kimura, Yumiko Mizuno, Yumi Kawase, Yasuyuki Abe, Miyuki Nagasaki, Yukiko Sekiguchi, Futoshi Nara, Keiko Oguchi-Oshima, Ryotaku Inoue, Tsuyoshi Nakamura, Kazuhiko Tamaki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1788-1792
S1P(3)-sparing S1P(1) agonists have attracted attention as a suppressant of autoimmunity with reduced side effects. Our synthetic efforts and extensive SAR studies led to the discovery of 10b named CS-2100 with the EC(50) value of 4.0 nM for human S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5d0df16308dff29d13f28a42fb0bce
https://doi.org/10.1016/j.bmcl.2011.12.019
https://doi.org/10.1016/j.bmcl.2011.12.019
Autor:
Wataru Tomisato, Keisuke Suzuki, Ryotaku Inoue, Yumi Kawase, Takashi Izumi, Keiko Oshima, Hiroshi Yuita, Takaichi Shimozato, Katsuyoshi Nakajima, Takahide Nishi, Shojiro Miyazaki, Futoshi Nara, Yukiko Iio, Takashi Kagari, Shin-ichi Inaba, Takashi Ohnuki, Toshiyasu Takemoto, Hiromi Doi
Publikováno v:
ACS Medicinal Chemistry Letters. 2:368-372
CS-0777 (3) is phosphorylated in vivo, and the phosphate of CS-0777 (CS-0777-P) (4) acts as a selective S1P receptor-1 (S1P1) modulator. We report herein the synthesis of CS-0777 and CS-0777-P, pharmacological effects such as S1P1 and S1P3 agonist ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b3b35dd0b318c4a46755aa807e3542
https://doi.org/10.1021/ml100301k
https://doi.org/10.1021/ml100301k
Autor:
Hamim Zahir, Kenneth E. Truitt, James B. Moberly, Timothy J. Carrothers, Takaichi Shimozato, Shashank Rohatagi, Shin-ichi Inaba
Publikováno v:
The Journal of Clinical Pharmacology. 49:50-62
Pharmacokinetic (PK) and exposure-response modeling of a selective sphingosine 1-phosphate receptor-1 modulator (CS-0777) was conducted in an iterative process to guide early clinical development decisions. A model based on preclinical data from monk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357b476d17e56ba0df81bf6921f66594
https://doi.org/10.1177/0091270008325672
https://doi.org/10.1177/0091270008325672
Publikováno v:
European Journal of Immunology. 37:2753-2763
Arthritis can be induced in mice by the injection of anti-type II collagen (anti-CII) Ab and LPS. To elucidate the role of IL-1 receptor antagonist (IL-1ra) in Ab-induced arthritis, WT and IL-1ra(-/-) mice were administered anti-CII Ab and LPS. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c7045925fe37a7b4f44ca4102f6cf7
https://doi.org/10.1002/eji.200737313
https://doi.org/10.1002/eji.200737313