Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Takaho Tsuchiya"'
Autor:
Hideki Maehara, Toshiya Kokaji, Atsushi Hatano, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Riku Egami, Takaho Tsuchiya, Haruka Ozaki, Keigo Morita, Masaki Shirai, Dongzi Li, Akira Terakawa, Saori Uematsu, Ken-ichi Hironaka, Satoshi Ohno, Hiroyuki Kubota, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Shinya Kuroda
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and translational efficiency control tissue-dominant protein production. However, the coordination
Externí odkaz:
https://doaj.org/article/98436c9b09ae438fad492d1943038991
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background Transcription factors (TFs) exhibit heterogeneous DNA-binding specificities in individual cells and whole organisms under natural conditions, and de novo motif discovery usually provides multiple motifs, even from a single chromat
Externí odkaz:
https://doaj.org/article/cad3172a5ae74a9a97ca59b9966a6d49
Autor:
Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Yuki Ito, Riku Egami, Saori Uematsu, Akira Terakawa, Yifei Pan, Hideki Maehara, Dongzi Li, Yunfan Bai, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Hiroyuki Kubota, Yutaka Suzuki, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Metabolic regulation in skeletal muscle is essential for blood glucose homeostasis. Obesity causes insulin resistance in skeletal muscle, leading to hyperglycemia and type 2 diabetes. In this study, we performed multiomic analysis of the ske
Externí odkaz:
https://doaj.org/article/dd5db8b9f47843dbacf9bbaaf001a016
Autor:
Teppei Nishino, Masaharu Yoshihara, Takahiro Nakayama, Takaho Tsuchiya, Saeko Tahara, Haruka Ozaki, Satoru Takahashi
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-6 (2022)
Abstract Objective Portal mesenchymal cells induce the epithelial differentiation of the bile ducts in the developing liver via one of the Delta-Notch signaling components, JAGGED1. Although this differential induction is crucial for normal liver phy
Externí odkaz:
https://doaj.org/article/a3d14774f77c43169b192c0b08c2ba12
Autor:
Riku Egami, Toshiya Kokaji, Atsushi Hatano, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Saori Uematsu, Akira Terakawa, Yunfan Bai, Yifei Pan, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102217- (2021)
Summary: Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic diseases. The systemic landscape of dysregulated inter-organ metaboli
Externí odkaz:
https://doaj.org/article/16277b1822a647cf9a657d68049c4b26
Autor:
Sarah Filippi, Chris P. Barnes, Paul D.W. Kirk, Takamasa Kudo, Katsuyuki Kunida, Siobhan S. McMahon, Takaho Tsuchiya, Takumi Wada, Shinya Kuroda, Michael P.H. Stumpf
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2524-2535 (2016)
Cellular signaling processes can exhibit pronounced cell-to-cell variability in genetically identical cells. This affects how individual cells respond differentially to the same environmental stimulus. However, the origins of cell-to-cell variability
Externí odkaz:
https://doaj.org/article/167f1e5d7573486fb67dbe22fa9a2acc
Autor:
Takaho Tsuchiya, Masashi Fujii, Naoki Matsuda, Katsuyuki Kunida, Shinsuke Uda, Hiroyuki Kubota, Katsumi Konishi, Shinya Kuroda
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 12, p e1005913 (2017)
Cells decode information of signaling activation at a scale of tens of minutes by downstream gene expression with a scale of hours to days, leading to cell fate decisions such as cell differentiation. However, no system identification method with suc
Externí odkaz:
https://doaj.org/article/6fd86c966a7a455a8babe7d749ee4249
Autor:
Takamasa Kudo, Shinsuke Uda, Takaho Tsuchiya, Takumi Wada, Yasuaki Karasawa, Masashi Fujii, Takeshi H Saito, Shinya Kuroda
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160548 (2016)
Signaling networks are made up of limited numbers of molecules and yet can code information that controls different cellular states through temporal patterns and a combination of signaling molecules. In this study, we used a data-driven modeling appr
Externí odkaz:
https://doaj.org/article/23bc4c1524f14c3694407c18a482dae5
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57037 (2013)
A wide range of growth factors encode information into specific temporal patterns of MAP kinase (MAPK) and CREB phosphorylation, which are further decoded by expression of immediate early gene products (IEGs) to exert biological functions. However, t
Externí odkaz:
https://doaj.org/article/ab134fabafea4cd2a214d0c351d80e9d
Autor:
Ruochong Wang, Futaba Kato, Rio Yasui Watson, Beedle, Aaron M., Call, Jarrod A., Yugo Tsunoda, Takeshi Noda, Takaho Tsuchiya, Makoto Kashima, Ayuna Hattori, Takahiro Ito
Publikováno v:
Life Science Alliance; May2024, Vol. 7 Issue 5, p1-15, 15p