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pro vyhledávání: '"Takahito Tanaka"'
Regulation of Epithelial-Mesenchymal Transition by E3 Ubiquitin Ligases and Deubiquitinase in Cancer
Autor:
Takahito Tanaka, Chihiro Sumita, Hidetoshi Hayashi, Yasumichi Inoue, Fumihiro Kawasaki, Daisuke Morishita, Yuka Itoh, Koichi Sato
Publikováno v:
Current Cancer Drug Targets. 16:110-118
Epithelial-mesenchymal transition (EMT) plays an important role in the development of tumor metastases by facilitating cell migration and invasion. One of the hallmarks of EMT is the diminished expression of E-cadherin and gain of mesenchymal traits,
Autor:
Fumihiro Kawasaki, Koichi Sato, Yuki Kawarada, Takahito Tanaka, Keishi Fukuura, Yasumichi Inoue, Hidetoshi Hayashi, Yuka Itoh
Publikováno v:
Scientific Reports
Transforming growth factor β (TGF-β) signaling facilitates tumor development during the advanced stages of tumorigenesis, but induces cell-cycle arrest for tumor suppression during the early stages. However, the mechanism of functional switching of