Neutrophil elastase inhibitor, ONO-5046 suppresses ozone-induced airway mucus hypersecretion in guinea pigs

Autor: Koichiro Matsumoto, Takahito Hirose, Sankei Nishima, Hiroshi Koto, Hiroyuki Miyazaki, Nobuyuki Hara, Hisamichi Aizawa, Hiroko Nogami, Hiroyuki Nakano

Publikováno v: European Journal of Pharmacology. 390:197-202

To investigate the role of neutrophil elastase in ozone-induced airway hypersecretion, we measured goblet cell secretion by using a semiquantitative morphometric technique in guinea pigs. The magnitude of mucus discharge was estimated from the mucus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1ad8ace024f979e7e2ebf0f2a59d26
https://doi.org/10.1016/s0014-2999(99)00921-8

Effects of epinastine hydrochloride on cholinergic neuro-effector transmission in canine tracheal smooth muscle

Autor: Koichiro Matsumoto, Sankei Nishima, Naotsugu Takahashi, Takahito Hirose, H. Inoue, N. Hara, Hiroyuki Nakano, Hisamichi Aizawa

Publikováno v: European journal of pharmacology. 358(1)

We determined the effects of epinastine hydrochloride, an anti-asthmatic drug, on cholinergic neuro-effector transmission in canine trachea. Isometric tension of tracheal strips was measured in the presence of indomethacin and propranolol. Epinastine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22baba833dd233e101c5f6dc9b36614
https://pubmed.ncbi.nlm.nih.gov/9809869

[A comparative study of cefepime for bacterial pneumonia]

Autor: Atsushi SAITO, Yoshiteru SHIGENO, Yuei IRABU, Hiroshi FUKUHARA, Soukichi ONODERA, Hitoshi NAKANO, Tetsuo SHIMIZU, Nobuhiro SASAKI, Hirotaka HASHIZUME, Yuka FUJITA, Takashi HIROSHIMA, Eiichi SAKAI, Akira SAITO, Ichiro NAKAYAMA, Yohmei HIRAGA, Mitsuhide OHMICHI, Kazuo TAKEBA, Ken OSONOI, Miyoko SAITO, Hirohisa KURODA, Masao TAMURA, Kazuki KONISHI, Yoshiaki MORI, Akiho OBARA, Kazuo OBARA, Hitoshi KOBAYASHI, Junichi OGAWA, Kunio KUDO, Munehiko ISHII, Masakichi MOTOMIYA, Akira WATANABE, Yoshihiro HONDA, Yutaka TOKUE, Mitsunobu HONMA, Masataka KATSU, Keisuke KUGA, Junzaburou KABE, Hitoshi ARIOKA, Hiroko ARIOKA, Masaru KOYAMA, Kouichiro NAKATA, Yoshitaka NAKAMORI, Osamu SAKAI, Jingorou SHIMADA, Kohya SHIBA, Masaki YOSHIDA, Hiroichi TANIMOTO, Tetsuo OKAMURA, Hiroyuki KOBAYASHI, Toru SAKAYORI, Hiroshi OSHITANI, Hiroaki TAKEDA, Shoichiro IRIMAJIRI, Yasuo MATSUOKA, Mitsuo OBANA, Takao OKUBO, Hirotada IKEDA, Fumio MATSUMOTO, Iwao SAKURAI, Takayuki TAKAHASHI, Shigeki ODAGIRI, Hiroshi TAKAHASHI, Kenichi TAKAHASHI, Yasutsugu AMANO, Takashi SAKUMA, Masaaki ARAKAWA, Koichi WADA, Takashi KAWASHIMA, Masanaga TAKATO, Shigeyuki HOSHINO, Osamu SEKINE, Yasutoshi SUZUKI, Toshihiko TAKEUCHI, Yoshimitsu HAYASHI, Kazuhide YAMAMOTO, Toshihiko YAMAMOTO, Kanzo SUZUKI, Toru MATSUURA, Satoru ADACHI, Fumiyuki KUZE, Takako MURAYAMA, Nobuo INABA, Yoshio ODA, Akira KAGIOKA, Fumio MIKI, Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Masaru SUMI, Toshiharu MATSUSHIMA, Masayoshi KAWANISHI, Makoto KIMURA, Shunkichi HIRAKI, Yohichi WATANABE, Masashi ARAKI, Takao SASAKI, Yukio MATSUMOTO, Yuji SUGIMOTO, Hidemi TERAMOTO, Michiro YAMAKIDO, Kenji HASEGAWA, Takashi TSUYA, Kenichiro SADAMOTO, Masao KUWABARA, Masanobu OKADA, Kenichi ARITA, Masao DOI, Kazuhiro DAIDO, Jitsuro YANAGIDA, Kenichiro WATANABE, Yuichi ATA, Motohiro SUGIHARA, Masato YUKUTAKE, Kouichi AWAYA, Yoshihisa IHARA, Yoshihiro SAWAE, Nobuyuki SHIMONO, Yukio KUMAGAI, Takahito HIROSE, Kei SATO, Kohtaro OHIZUMI, Youichiro ICHIKAWA, Masako TANAKA, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Mikio KUBUSHIRO, Toshihiro HIGASHI, Kohei HARA, Shigeru KOHNO, Hironobu KOGA, Mitsuo KAKU, Keizo MATSUMOTO, Kazunori OHISHI, Kiyoshi SHIMA, Shinobu TAKENAKA, Masaru NASU, Yoichiro GOTO, Tohru YAMAZAKI, Hiroyuki NAGAI, Takayoshi TASHIRO, Hiroshi NAGAOKA, Kaoru NAKAMA, Nobuya OGAWA, Nobuchika KUSANO

Publikováno v: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 66(7)

The efficacy, safety and usefulness of cefepime (CFPM), a new cephem antibiotic, in bacterial pneumonia, were evaluated in a comparative study against ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (nomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184e40e9efdf2d2d172feaf4e0c0f613
https://pubmed.ncbi.nlm.nih.gov/1431364

The effect of prostacyclin on increased hydraulic conductivity of pulmonary exchange vessels following microembolization in dogs

Autor: Kenzo Tanaka, Takahito Hirose, Mariko Domae, Emiko Aoki, Masayoshi Ishibashi, Togo Ikeda

Publikováno v: Microvascular Research. 26:193-204

Prostacyclin (PG I 2 ) generated by vascular endothelium is a strong antiaggregating substance. As platelet aggregation and release of humoral factor(s) have been reported to be crucial in the pathogenesis of acute lung injury following pulmonary mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7522e4040f637362e583c012aee7d9
https://doi.org/10.1016/0026-2862(83)90070-5

Protective effect of a thromboxane synthetase inhibitor, OKY-1581, on increased lung vascular permeability in pulmonary microembolization in dogs

Autor: Takahito Hirose, Masayoshi Ishibashi, Togo Ikeda, Mariko Domae, Kenzo Tanaka, Emiko Aoki

Publikováno v: Prostaglandins, Leukotrienes and Medicine. 10:187-196

To evaluate the potential beneficial effect of a thromboxane synthetase inhibitor, OKY-1581, on increased pulmonary vascular permeability in pulmonary microembolization, we have measured the filtration coefficient in the nonembolized lung after unila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40c03f383d557587c4ca15af509a507
https://doi.org/10.1016/s0262-1746(83)80009-2