Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Takahito, Nakahara"'
Autor:
Yukitaka, Ideyama 1, Masafumi, Kudoh 1, Kyoko, Tanimoto 1, Yoko, Susaki 1, Taiki, Nanya 1, Takahito, Nakahara 1, Hiroko, Ishikawa 1, Takashi, Fujikura 1, Hideyuki, Akaza 2, Hisataka, Shikama 1, *
Publikováno v:
In Japanese Journal of Pharmacology 1999 79(2):213-220
Autor:
Yoshihiro Murakami, Takahito Nakahara, Kentaro Yamanaka, Shintaro Nishimura, Keisuke Mitsuoka, Sosuke Miyoshi, Akihiro Noda, Aya Kita, Takahiro Matsuya
Publikováno v:
Nuclear Medicine and Biology. 40:221-226
Introduction Sepantronium bromide (YM155) is an antitumor drug in development and is a first-in-class chemical entity, which is a survivin suppressant. We developed a radiosynthesis of [ 11 C]YM155 to non-invasively evaluate its tissue and tumor dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ec537e2d415c3fc621ec39514d5af7
https://doi.org/10.1016/j.nucmedbio.2012.10.002
https://doi.org/10.1016/j.nucmedbio.2012.10.002
Autor:
Takahito Nakahara, Aya Kita, Masahiro Takeuchi, Kentaro Yamanaka, Fumiko Kiyonaga, Masao Sasamata, Tomohiro Yamauchi, Naoki Kaneko
Publikováno v:
Clinical Cancer Research. 17:5423-5431
Purpose: Aggressive cell growth and chemoresistance are notorious obstacles in melanoma therapy. Accumulating evidence suggests that survivin is preferentially expressed in cancer cells and plays a crucial role in cell division and apoptosis dysfunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe91ce60e9ba8479340bdcd82fb3baf
https://doi.org/10.1158/1078-0432.ccr-10-3410
https://doi.org/10.1158/1078-0432.ccr-10-3410
Autor:
Takahito Nakahara, Isao Kinoyama, Masao Sasamata, Hiroshi Koutoku, Shinji Hatakeyama, Kenji Nakano, Akira Matsuhisa, Masahiro Takeuchi, Kentaro Yamanaka, Takao Shishido, Aya Kita
Publikováno v:
Anti-Cancer Drugs. 22:454-462
Survivin, an apoptotic inhibitor, is overexpressed in the majority of human tumor types and represents a novel target for anticancer therapy. Taxanes induce a mitotic cell-cycle block through the inhibition of microtubule depolymerization, with subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef426f6b0f0af5a6e815231b4ef3190d
https://doi.org/10.1097/cad.0b013e328344ac68
https://doi.org/10.1097/cad.0b013e328344ac68
Autor:
Naoki Kaneko, Kentaro Yamanaka, Takahito Nakahara, Hiroshi Koutoku, Nobuyuki Izumisawa, Kenji Nakano, Aya Kita, Masao Sasamata, Masamichi Mori, Mari Nakata
Publikováno v:
Leukemia Research. 35:787-792
YM155, a novel small-molecule that down-regulates survivin, exhibits broad, potent antitumor activity against a range of human tumors. We evaluated the activity of YM155 in aggressive non-Hodgkin lymphoma. In a number of diffuse large B-cell lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0d74a127ba0f6edb91ae3b8dd09c22
https://doi.org/10.1016/j.leukres.2010.11.016
https://doi.org/10.1016/j.leukres.2010.11.016
Autor:
Akira Matsuhisa, Isao Kinoyama, Nobuaki Amino, Masao Sasamata, Takahito Nakahara, Kentaro Yamanaka, Masamichi Mori, Masafumi Kudou, Fumiko Tominaga, Masahiro Takeuchi, Aya Kita
Publikováno v:
Cancer Science. 102:614-621
Antitumor activities of YM155, a novel small-molecule survivin suppressant, were investigated in a wide variety of human cancer cell lines and xenograft models. YM155 inhibited the growth of 119 human cancer cell lines, with the greatest activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f9a4a4f4184a20f94e09b785c8d9a6
https://doi.org/10.1111/j.1349-7006.2010.01834.x
https://doi.org/10.1111/j.1349-7006.2010.01834.x
Autor:
Kiyoko Kuwata, Kazuhiko Nakagawa, Kentaro Yamanaka, Erina Hatashita, Ken Takezawa, Isamu Okamoto, Takahito Nakahara, Yuki Yamada, Tsutomu Iwasa, Aya Kita, Masahiro Fukuoka, Hiroshi Koutoku, Masao Sasamata
Publikováno v:
British Journal of Cancer
Background: Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We have now investigated the effects of the combination of YM155, a novel small-molecule inhibitor of survivin expression, and pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f33219e8b80bd575f31ea56302a1f7f
http://europepmc.org/articles/PMC2905296
http://europepmc.org/articles/PMC2905296
Autor:
Yukitaka Ideyama, Yoshihiro Ami, Takahito Nakahara, Hideyuki Akaza, Naoto Miyanaga, Toru Shimazui
Publikováno v:
Japanese Journal of Cancer Research : Gann
Multiple occurrence or recurrence after transurethral resection is an important characteristic of superficial bladder tumors. To study bladder carcinogenesis, we focused on detection of telomerase activation, which was investigated in several human c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcdd7a67502f61100d14c05f943e54c
https://doi.org/10.1111/j.1349-7006.2002.tb01283.x
https://doi.org/10.1111/j.1349-7006.2002.tb01283.x
Autor:
Masafumi Kudoh, Hiroko Ishikawa, Takahito Nakahara, Hideyuki Akaza, Yukitaka Ideyama, Taiki Nanya, Hisataka Shikama, Takashi Fujikura, Kyoko Tanimoto, Yoko Susaki
Publikováno v:
Japanese Journal of Pharmacology. 79:213-220
The concentrations of androstenedione and dehydroepiandrosterone, products of C17-20 lyase, in the medium after a 6-hr incubation of NCI-H295 cells were decreased by YM116 (2-(1H-imidazol-4-ylmethyl)-9H-carbazole) (IC50: 3.6 and 2.1 nM) and ketoconaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::767f66f4d5401d42dc756d0bb7cc947f
https://doi.org/10.1254/jjp.79.213
https://doi.org/10.1254/jjp.79.213
Autor:
Minoru Okada, Takahito Nakahara, Takashi Fujikura, Hideyuki Akaza, Yoko Susaki, Yukitaka Ideyama, Taiki Nanya, Toru Yoden, Hiroko Ishikawa, Kyoko Tanimoto, Hisataka Shikama, Masafumi Kudoh
Publikováno v:
The Prostate. 37:10-18
BACKGROUND The purpose of this study was to determine the effects of a nonsteroidal C17–20 lyase inhibitor, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole (YM116), on serum concentrations of androgens and ventral prostatic weight in rats. METHODS Serum co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e657856cbb981a40f1f6b60d39f6f16
https://doi.org/10.1002/(sici)1097-0045(19980915)37:1<10::aid-pros3>3.0.co
https://doi.org/10.1002/(sici)1097-0045(19980915)37:1<10::aid-pros3>3.0.co