Výsledky vyhledávání - "Takahisa Sugita"

Involvements of mitogen-activated protein kinase cascades in osteoclastogenesis

Publikováno v: Inflammation and Regeneration. 31:425-430

Osteoclasts play critical roles in bone resorption at the site of inflammatory joints, and receptor activator of nuclear factor-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) are required for osteoclastogenesis. RANKL, a member o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32c1f5dd148df1fa8280842129d5fac8
https://doi.org/10.2492/inflammregen.31.425

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Fingolimod (FTY720) ameliorates experimental autoimmune encephalomyelitis (EAE): I. Oral administration of FTY720 effectively inhibits relapse of EAE

Autor: Atsushi Fukunari, Kenji Chiba, Hirotoshi Kataoka, Kyoko Shimano, Yasuhiro Maeda, Takahisa Sugita, Mamoru Koyama, Kunio Sugahara, Noriyasu Seki

Publikováno v: Inflammation and Regeneration. 30:451-457

Experimental autoimmune encephalomyelitis (EAE) is a CD4 T cell-mediated disease model for multiple sclerosis (MS). When SJL/J mice are immunized with myelin proteolipid protein (PLP), EAE symptoms were developed within 2 weeks, remitted thereafter,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::317e3367a83a9b22201db3ec165cafa0
https://doi.org/10.2492/inflammregen.30.451

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Fingolimod (FTY720) ameliorates experimental autoimmune encephalomyelitis (EAE): II. FTY720 decreases infiltration of Th17 and Th1 cells into the central nervous system in EAE

Autor: Hirotoshi Kataoka, Yasuhiro Maeda, Kunio Sugahara, Noriyasu Seki, Takahisa Sugita, Kenji Chiba

Publikováno v: Inflammation and Regeneration. 30:542-548

Fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, is highly effective in experimental autoimmune encephalomyelitis (EAE) and decreases circulating mature lymphocytes by inhibiting S1P-dependent lymphocyte egress from secondary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4751dcc5e71f1ddeb9f2e2338c633efb
https://doi.org/10.2492/inflammregen.30.542

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Targeting therapy in rheumatoid arthritis

Autor: Takahisa Sugita

Publikováno v: Folia Pharmacologica Japonica. 129:177-181

関節リウマチなど複雑な免疫系疾患の病因・病態の理解が深まる中で，TNFαをターゲットとする生物学的製剤の開発により，関節リウマチの症状改善に加えて関節破壊の進展を制御する�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e7b8883c4bb052ab110fe21ed6ab2e
https://doi.org/10.1254/fpj.129.177

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Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by α1-3 fucosyltransferase-VII

Autor: Takahisa Sugita, Masahiko Miyashiro, Sachiko Furuya, Kotomi Fujishige

Publikováno v: Biochemical and Biophysical Research Communications. 324:98-107

The sialyl Lewis X (sLe(x)) determinant on leukocytes serves as a ligand for selectin family cell adhesion molecules, and selectin-carbohydrate interaction is considered to play an important role in the process of leukocyte extravasation during infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280631c40246dbeb5bd6e7618e55eb87
https://doi.org/10.1016/j.bbrc.2004.09.025

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Development of a Sensitive Separation and Quantification Method for Sialyl Lewis X and Lewis X Involving Anion-Exchange Chromatography: Biochemical Characterization of 1-3 Fucosyltransferase-VII

Autor: Takahisa Sugita, Sachiko Furuya, Masahiko Miyashiro

Publikováno v: Journal of Biochemistry. 136:723-731

The biosynthesis of the carbohydrate antigen sialyl Lewis X (sLe(x)) in human leukocytes is mediated by alpha1-3 fucosyltransferase-VII (FucT-VII), which catalyzes the transfer of fucose from GDP-beta-fucose to the 3-OH of alpha2-3 sialyl N-acetyllac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d02665ce76fddad415e8b14be48cc1b
https://doi.org/10.1093/jb/mvh179

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Alternative splicing and gene structure of the transforming growth factor β-activated kinase 1

Autor: Clare Dempsey, F Guesdon, Takahisa Sugita, Hiroaki Sakurai

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1517:46-52

We have identified a fourth splice variant of the TGFβ-activated kinase (TAK1), called TAK1-d, and identified an error in the previously published TAK1-c sequence. Our data shows that the c and d variants encode proteins whose carboxyl ends differ m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a7cfb9ac504dfa8a548542a7b4d2c3
https://doi.org/10.1016/s0167-4781(00)00258-x

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Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1

Autor: Hiroaki Sakurai, Hidetaka Miyoshi, Takahisa Sugita, Junko Mizukami

Publikováno v: FEBS Letters. 474:141-145

TAK1 is a mitogen-activated protein kinase kinase kinase (MAP3K) that is involved in the c-Jun N-terminal kinase/p38 MAPKs and NF-κB signaling pathways. Here, we characterized the molecular mechanisms of TAK1 activation by its specific activator TAB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8aae326124d7c3c0d013c86e061fdc
https://doi.org/10.1016/s0014-5793(00)01588-x

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Immunosuppressive effects of the heat shock protein 90-binding antibiotic geldanamycin

Autor: Hidetaka Miyoshi, Sumiko Tanaka, Takahisa Sugita, Tetsuo Ohnuki, Takanori Murakami

Publikováno v: IUBMB Life. 47:587-595

Ansamycin antibiotic, geldanamycin has a unique pharmacological effect to bind to heat shock protein 90 (hsp90) and deplete hsp90 substrates. We investigated the immunopharmacological effects of geldanamycin. Geldanamycin depleted cellular Raf-1 of r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7b814be9bd5f5cd8979eacdba0f00b
https://doi.org/10.1080/15216549900201633

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