Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Takahisa Shibata"'
Autor:
Toshiaki Ban, Yoshiro Maezawa, Ryo Terayama, Koutaro Yokote, Takahisa Shibata, Masaya Koshizaka
Publikováno v:
Diabetes. 69
Objective: Early prevention of renal dysfunction progression and cardiovascular disease is important in diabetes. We aimed to determine the risk factors for renal dysfunction and cardiovascular disease among medical insurance subscribers between 40 a
Publikováno v:
Internal Medicine. 52:1625-1628
We herein report the cases of two patients with bilateral symmetrical pallidal lesions mimicking hypoxic encephalopathy following severe anemia associated with gastrointestinal hemorrhage despite a lack of carbon monoxide intoxication. Although sever
The Rho Guanine Nucleotide Exchange Factor AKAP13 (BRX) Is Essential for Cardiac Development in Mice
Autor:
C. Mayers, Paul H. Driggers, X. Catherine Guo, Hisashi Koide, Marat Gorivodsky, Mones Abu-Asab, Monica Venere, Tomoshige Kino, Jennifer Wadell, James H. Segars, Kate McLean, Mahua Mukhopadhyay, Alex Grinberg, Takahisa Shibata, Heiner Westphal, Minnie Malik
Publikováno v:
Journal of Biological Chemistry. 285:12344-12354
A fundamental biologic principle is that diverse biologic signals are channeled through shared signaling cascades to regulate development. Large scaffold proteins that bind multiple proteins are capable of coordinating shared signaling pathways to pr
Autor:
Yasushi Saito, Tomoaki Tanaka, Laura Grossmann, Ichiro Tatsuno, Masami Fuse, Tatsuji Yasuda, Tomohiko Yoshida, Mie Asanuma, Koichi Ueno, Takahisa Shibata, Taeko Yonekawa
Publikováno v:
FEBS Letters. 580:5203-5207
Isoprenylation of geranylgeranyl-pyrophosphate (GGPP) is critical for activation of small GTPases. We examined the roles of GGPP synthase (GGPPS) during the differentiation induced by the cell-to-cell contact in osteoblastic cell line MC3T3-E1 cells.
Autor:
Norihiko Misawa, Naokatsu Saeki, Ichiro Tatsuno, Yasushi Saito, Takahisa Shibata, Chikari Takeo
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 12:330-337
In mammals, a fully developed, highly branched vascular system specialized for each particular organ or tissue is essential for obtaining metabolic nutrients supply. The formation of a blood-brain barrier that protects against environmental insults i
Autor:
Ichiro Tatsuno, Masami Fuse, Yasushi Saito, Keiko Suyama, Takahisa Shibata, Chikari Takeo, Yoshihiko Noguchi, Yuko Otsuka, Tomohiko Yoshida
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 11:335-340
Forty Type IIb or IV hyperlipidemic patients (serum triglyceride concentrations were higher than 150 mg/dl) were treated with fenofibrate (300 mg/day) for 12 weeks. Lipid profile and uric acid metabolism were evaluated before and after the treatment;
Publikováno v:
Internal Medicine. 38:426-432
A 60-year-old woman was admitted with severe hyponatremia. Basal values of adrenocorticotropic hormone (ACTH), thyroid hormone and cortisol were normal on admission. Impairment of water diuresis was observed by water loading test. Initially, we diagn
Autor:
Ichiro Tatsuno, Yasushi Saito, Takahisa Shibata, Tomohiko Yoshida, Hisashi Koide, Keiko Suyama, Tomoaki Tanaka, Yoshihiko Noguchi, Sawako Suzuki, Daigaku Uchida
Publikováno v:
Peptides. 29(12)
Vasopressin was reported to stimulate secretion of both cortisol and aldosterone through eutopic V1a receptors in adrenal gland. Recently, adrenal hyper-responsiveness of plasma cortisol to vasopressin with eutopic overexpession of V1a receptors has
Autor:
Toshitaka Nagao, Takahisa Shibata, Ichiro Tatsuno, Yasushi Saito, Azusa Nagata, Tomohiko Yoshida, Tomoaki Tanaka, Hiroaki Hosaka
Publikováno v:
Peptides. 29(8)
Although the neuropeptide Y (NPY) family has been demonstrated to control bone metabolism, the role of pancreatic polypeptide (PP), which has structural homology with NPY and peptide YY (PYY) to share the NPY family receptors, in peripheral bone tiss
Autor:
Takahisa Shibata, Ichiro Tatsuno, Keiko Suyama, Yasushi Saito, Yoshihiko Noguchi, Tomohiko Yoshida, Tomoaki Tanaka
Publikováno v:
Oncology reports. 18(5)
Bisphosphonates cause apoptosis to various types of cancer cells including breast cancer. Inhibition of the mevalonate pathway was reported to be involved in the apoptosis induced by bisphosphonates, but its precise mechanism has not been unveiled. I