Výsledky vyhledávání - "Takahisa NAKAMURA"

Akademický článek

Mechanistic insights into the peroxisome proliferator-activated receptor alpha as a transcriptional suppressor

Publikováno v: Frontiers in Medicine, Vol 9 (2022)

Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent hepatic disorders that 20-30% of the world population suffers from. The feature of NAFLD is excess lipid accumulation in the liver, exacerbating multiple metabolic syndromes such

Externí odkaz: https://doaj.org/article/7632f71b50ab45f6959cd4da18afecf8

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Akademický článek

Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing

Publikováno v: Cell Reports, Vol 30, Iss 3, Pp 672-686.e8 (2020)

Summary: Almost all life forms can detect and decode light information for adaptive advantage. Examples include the visual system, in which photoreceptor signals are processed into virtual images, and the circadian system, in which light entrains a p

Externí odkaz: https://doaj.org/article/f3d3889d1421467786d668b9cc43654f

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Akademický článek

A Label-Free Electrical Impedance Spectroscopy for Detection of Clusters of Extracellular Vesicles Based on Their Unique Dielectric Properties

Autor: Yuqian Zhang, Kazutoshi Murakami, Vishnupriya J. Borra, Mehmet Ozgun Ozen, Utkan Demirci, Takahisa Nakamura, Leyla Esfandiari

Publikováno v: Biosensors, Vol 12, Iss 2, p 104 (2022)

Extracellular vesicles (EVs) have gained considerable attention as vital circulating biomarkers since their structure and composition resemble the originating cells. The investigation of EVs’ biochemical and biophysical properties is of great impor

Externí odkaz: https://doaj.org/article/0b3140f327394037943365cefaca9e28

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Akademický článek

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

Autor: Cai Zhang, Joonbae Seo, Kazutoshi Murakami, Esam S. B. Salem, Elise Bernhard, Vishnupriya J. Borra, Kwangmin Choi, Celvie L. Yuan, Calvin C. Chan, Xiaoting Chen, Taosheng Huang, Matthew T. Weirauch, Senad Divanovic, Nathan R. Qi, Hala Einakat Thomas, Carol A. Mercer, Haruhiko Siomi, Takahisa Nakamura

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

The RNA-induced silencing complex (RISC) represses gene expression via micro-RNA guided mRNA silencing. Here, the authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disrupt

Externí odkaz: https://doaj.org/article/38c391e9f41444b882b89e0d90e18efc

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Akademický článek

RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases

Autor: Esam S. B. Salem, Andrew D. Vonberg, Vishnupriya J. Borra, Rupinder K. Gill, Takahisa Nakamura

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 6 (2019)

The increasing prevalence of worldwide obesity has emerged as a major risk factor for type 2 diabetes (T2D), hepatosteatosis, and cardiovascular disease. Accumulating evidence indicates that obesity has strong inflammatory underpinnings tightly linke

Externí odkaz: https://doaj.org/article/e6e120749b454fafab437a887004aaf3

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Akademický článek

A Critical Role for PKR Complexes with TRBP in Immunometabolic Regulation and eIF2α Phosphorylation in Obesity

Autor: Takahisa Nakamura, Ryan C. Kunz, Cai Zhang, Taishi Kimura, Celvie L. Yuan, Brenna Baccaro, Yuka Namiki, Steven P. Gygi, Gökhan S. Hotamisligil

Publikováno v: Cell Reports, Vol 11, Iss 2, Pp 295-307 (2015)

Aberrant stress and inflammatory responses are key factors in the pathogenesis of obesity and metabolic dysfunction, and the double-stranded RNA-dependent kinase (PKR) has been proposed to play an important role in integrating these pathways. Here, w

Externí odkaz: https://doaj.org/article/317f8e3d842c4ff381a6c698c808cbdc

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Akademický článek

Extracellular Vesicles: A Potential Novel Regulator of Obesity and Its Associated Complications

Autor: Ahlee Kim, Amy S. Shah, Takahisa Nakamura

Publikováno v: Children, Vol 5, Iss 11, p 152 (2018)

Childhood obesity continues to be a major public health concern. Obesity causes various metabolic complications, including insulin resistance, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), dyslipidemia, and cardiovascula

Externí odkaz: https://doaj.org/article/9c259f89d49a43c49f30ccf40b2cb2af

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