Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Takahisa Motomura"'
Autor:
Kazuki Otake, Minoru Ubukata, Noboru Nagahashi, Naoki Ogawa, Yoshiji Hantani, Rie Hantani, Tsuyoshi Adachi, Akihiro Nomura, Keishi Yamaguchi, Mariko Maekawa, Hideaki Mamada, Takahisa Motomura, Motohide Sato, Kazuhito Harada
Publikováno v:
ACS Medicinal Chemistry Letters. 14:658-665
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71fe68e2a2ec3dc25be3eb482289d147
https://doi.org/10.1021/acsmedchemlett.3c00067
https://doi.org/10.1021/acsmedchemlett.3c00067
Autor:
Hiroaki Iwata, Tatsuru Matsuo, Hideaki Mamada, Takahisa Motomura, Mayumi Matsushita, Takeshi Fujiwara, Kazuya Maeda, Koichi Handa
Publikováno v:
Journal of Chemical Information and Modeling. 62(17):4057-4065
Pharmacokinetic research plays an important role in the development of new drugs. Accurate predictions of human pharmacokinetic parameters are essential for the success of clinical trials. Clearance (CL) and volume of distribution (Vd) are important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e728012ab483d5eeb76f953ddf074fd7
http://hdl.handle.net/2433/282825
http://hdl.handle.net/2433/282825
Autor:
Yasuo Terasako, Takahisa Motomura, Genki Mori, Satoki Doi, Yoshitomi Nakane, Takuya Orita, Tomoko Iwanaga, Tatsuo Akaki, Shingo Obika, Ayumi Fujishima, Hiroshi Ueno, Yuki Bessho, Tsuyoshi Adachi, Maki Yamakawa, Yoshinori Hara, Katsutaka Yasue, Minoru Ubukata
Publikováno v:
Bioorganicmedicinal chemistry. 52
Pyruvate dehydrogenase kinases (PDHKs) are fascinating drug targets for numerous diseases, including diabetes and cancers. In this report, we describe the result of our structure-based drug design from tricyclic lead compounds that led to the discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaeb6dd3769edaea55c21cd1394aea9
https://pubmed.ncbi.nlm.nih.gov/34808405
https://pubmed.ncbi.nlm.nih.gov/34808405
Autor:
Koichi Handa, Takahisa Motomura, Takeshi Fujiwara, Tatsuru Matsuo, Hiroaki Iwata, Maeda Kazuya, Hideaki Mamada, Mayumi Matsushita
Publikováno v:
Journal of pharmaceutical sciences. 110(4)
Research into pharmacokinetics plays an important role in the development process of new drugs. Accurately predicting human pharmacokinetic parameters from preclinical data can increase the success rate of clinical trials. Since clearance (CL) which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d955f249c12184b35b1cbba1eb2281e
https://pubmed.ncbi.nlm.nih.gov/33497658
https://pubmed.ncbi.nlm.nih.gov/33497658
Autor:
Yuji Matsuzaki, Hisashi Shinkai, Satoru Ikeda, Hiroshi Kawakami, Motohide Sato, Takashi Matsuda, Takahisa Motomura, Yoshiharu Ito, Masaki Yamashita, Kazunobu Yamataka, Hisateru Aramaki
Publikováno v:
Journal of Medicinal Chemistry. 52:4869-4882
Human immunodeficiency virus type 1 (HIV-1) integrase is a crucial target for antiretroviral drugs, and several keto-enol acid class (often referred to as diketo acid class) inhibitors have clinically exhibited marked antiretroviral activity. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa71b58ebb41760c61b1471097875bbf
https://doi.org/10.1021/jm900460z
https://doi.org/10.1021/jm900460z
Publikováno v:
Bulletin of the Chemical Society of Japan. 78:142-146
Oligo(naphthalene-2,3-diyl)s are synthesized by the palladium-catalyzed cross-coupling reactions of 2-naphthyl-zinc compounds with 2-bromonaphthalene derivatives. An NMR analysis together with an X-ray diffraction study supports the conjecture that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821b0d2ed57222fe9088d4215cea8571
https://doi.org/10.1246/bcsj.78.142
https://doi.org/10.1246/bcsj.78.142
Autor:
Hisashi Takatsuki Shinkai, Takashi Matsuda, Motohide Sato, Hiroshi Kawakami, Yoshiharu Ito, Yuji Matsuzaki, Satoru Ikeda, Masao Matsuoka, Eiichi Kodama, Takahisa Motomura, Masaki Yamashita, Kazunobu Yamataka, Hisateru Aramaki, Wataru Watanabe
Publikováno v:
Journal of Medicinal Chemistry. 49:1506-1508
The viral enzyme integrase is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents a remaining target for antiretroviral drugs. Here, we describe the modification of a quinolone antibiotic to produce the novel i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a003499266ea4c756de188fab95d9ef
https://doi.org/10.1021/jm0600139
https://doi.org/10.1021/jm0600139
Autor:
Takeshi Ohta, Hidekazu Ozeki, Hisashi Shinkai, Noboru Furukawa, Takahisa Motomura, Itsuo Uchida
Publikováno v:
ChemInform. 30
During an investigation of drugs for improving the β-cell response to glucose, we found that 4-cyclohexyl-4-oxobutyric acid selectively improved glucose-stimulated insulin release and glucose tolerance in both normal and diabetic rats. A series of 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b292cf897ddb96da372d1cfdaae58e42
https://doi.org/10.1002/chin.199921078
https://doi.org/10.1002/chin.199921078