Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Takahisa Miyao"'
Autor:
Hiroto Ishii, Rin Endo, Sanae Hamanaka, Nobuyuki Hidaka, Maki Miyauchi, Naho Hagiwara, Takahisa Miyao, Tohru Yamamori, Tatsuya Aiba, Nobuko Akiyama, Taishin Akiyama
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract The analysis of cells frozen within the International Space Station (ISS) will provide crucial insights into the impact of the space environment on cellular functions and properties. The objective of this study was to develop a method for cr
Externí odkaz:
https://doaj.org/article/2f1bab540a074b66b49b8cfa6f685772
Autor:
Yuya Maruyama, Yusuke Ohsawa, Takayuki Suzuki, Yuko Yamauchi, Kohsuke Ohno, Hitoshi Inoue, Akitoshi Yamamoto, Morimichi Hayashi, Yuji Okuhara, Wataru Muramatsu, Kano Namiki, Naho Hagiwara, Maki Miyauchi, Takahisa Miyao, Tatsuya Ishikawa, Kenta Horie, Mio Hayama, Nobuko Akiyama, Takatsugu Hirokawa, Taishin Akiyama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Sphingosine 1-phosphate receptor 1 (S1PR1), a G protein-coupled receptor, is required for lymphocyte trafficking, and is a promising therapeutic target in inflammatory diseases. Here, we synthesize a competitive S1PR1 antagonist, KSI-6666, t
Externí odkaz:
https://doaj.org/article/785e30ba214647e5951095171113232d
Autor:
Yuki Takakura, Moeka Machida, Natsumi Terada, Yuka Katsumi, Seika Kawamura, Kenta Horie, Maki Miyauchi, Tatsuya Ishikawa, Nobuko Akiyama, Takao Seki, Takahisa Miyao, Mio Hayama, Rin Endo, Hiroto Ishii, Yuya Maruyama, Naho Hagiwara, Tetsuya J. Kobayashi, Naoto Yamaguchi, Hiroyuki Takano, Taishin Akiyama, Noritaka Yamaguchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Autophagy is primarily activated by cellular stress, such as starvation or mitochondrial damage. However, stress-independent autophagy is activated by unclear mechanisms in several cell types, such as thymic epithelial cells (TECs). Here we
Externí odkaz:
https://doaj.org/article/3b23fba647ea4ea2a84f733c4cb7a6bd
Autor:
Kenta Horie, Kano Namiki, Kyouhei Kinoshita, Maki Miyauchi, Tatsuya Ishikawa, Mio Hayama, Yuya Maruyama, Naho Hagiwara, Takahisa Miyao, Shigeo Murata, Tetsuya J. Kobayashi, Nobuko Akiyama, Taishin Akiyama
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The thymus has the ability to regenerate from acute injury caused by radiation, infection, and stressors. In addition to thymocytes, thymic epithelial cells in the medulla (mTECs), which are crucial for T cell self-tolerance by ectopically expressing
Externí odkaz:
https://doaj.org/article/314e1101ffcf4d2c89c2a6b04c520ad3
Autor:
Tatsuya Ishikawa, Hiroto Ishii, Takahisa Miyao, Kenta Horie, Maki Miyauchi, Nobuko Akiyama, Taishin Akiyama
Publikováno v:
Bio-Protocol, Vol 13, Iss 1 (2023)
Accessible chromatin regions modulate gene expression by acting as cis-regulatory elements. Understanding the epigenetic landscape by mapping accessible regions of DNA is therefore imperative to decipher mechanisms of gene regulation under specific b
Externí odkaz:
https://doaj.org/article/47b0dd83424245fab04940d060a96437
Autor:
Taku Ito-Kureha, Takahisa Miyao, Saori Nishijima, Toru Suzuki, Shin-ichi Koizumi, Alejandro Villar-Briones, Akinori Takahashi, Nobuko Akiyama, Masahiro Morita, Isao Naguro, Hiroki Ishikawa, Hidenori Ichijo, Taishin Akiyama, Tadashi Yamamoto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The CCR4-NOT complex catalyzes mRNA deadenylation and hence regulates protein translation. Here the authors show that CNOT3 regulation of this complex is needed for positive selection of thymocytes via a mechanism involving inhibition of pro-apoptoti
Externí odkaz:
https://doaj.org/article/e8632bde18164a9fa0e055cc88ae0bea
Autor:
Takahisa Miyao, Maki Miyauchi, S Thomas Kelly, Tommy W Terooatea, Tatsuya Ishikawa, Eugene Oh, Sotaro Hirai, Kenta Horie, Yuki Takakura, Houko Ohki, Mio Hayama, Yuya Maruyama, Takao Seki, Hiroto Ishii, Haruka Yabukami, Masaki Yoshida, Azusa Inoue, Asako Sakaue-Sawano, Atsushi Miyawaki, Masafumi Muratani, Aki Minoda, Nobuko Akiyama, Taishin Akiyama
Publikováno v:
eLife, Vol 11 (2022)
Medullary thymic epithelial cells (mTECs) are critical for self-tolerance induction in T cells via promiscuous expression of tissue-specific antigens (TSAs), which are controlled by the transcriptional regulator, AIRE. Whereas AIRE-expressing (Aire+)
Externí odkaz:
https://doaj.org/article/baee0fabd6c842149f5ac54fb4e93aa2
Autor:
Kenta Horie, Hiroki Sasanuma, Takashi Kudo, Shin-ichiro Fujita, Maki Miyauchi, Takahisa Miyao, Takao Seki, Nobuko Akiyama, Yuki Takakura, Miki Shimbo, Hyojung Jeon, Masaki Shirakawa, Dai Shiba, Nobuaki Yoshida, Masafumi Muratani, Satoru Takahashi, Taishin Akiyama
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Secondary lymphoid organs are critical for regulating acquired immune responses. The aim of this study was to characterize the impact of spaceflight on secondary lymphoid organs at the molecular level. We analysed the spleens and lymph nodes
Externí odkaz:
https://doaj.org/article/e20455f99c9a4ddcbb21f6fed3409fee
Autor:
Susanne Herppich, Aras Toker, Beate Pietzsch, Yohko Kitagawa, Naganari Ohkura, Takahisa Miyao, Stefan Floess, Shohei Hori, Shimon Sakaguchi, Jochen Huehn
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Regulatory T (Treg) cells mainly develop within the thymus and arise from CD25+Foxp3− (CD25+ TregP) or CD25−Foxp3+ (Foxp3+ TregP) Treg cell precursors resulting in Treg cells harboring distinct transcriptomic profiles and complementary T cell rec
Externí odkaz:
https://doaj.org/article/9a5401e312c7446ebd3e9fe0ba2aedd4
Autor:
Yuya Maruyama, Yusuke Ohsawa, Takayuki Suzuki, Yuko Yamauchi, Kohsuke Ohno, Hitoshi Inoue, Akitoshi Yamamoto, Morimichi Hayashi, Yuji Okuhara, Maki Miyauchi, Takahisa Miyao, Tatsuya Ishikawa, Kenta Horie, Mio Hayama, Nobuko Akiyama, Takatsugu Hirokawa, Taishin Akiyama
Sphingosine 1-phosphate receptor 1 (S1PR1), a G protein-coupled receptor, is required for lymphocyte trafficking, and is a promising therapeutic target in inflammatory diseases. To find potent S1PR1 antagonists, identification of the structural basis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d2b4bac765c2a8de06eedae9518248
https://doi.org/10.1101/2023.05.08.539826
https://doi.org/10.1101/2023.05.08.539826
