Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Takahisa, Shinomiya"'
Publikováno v:
Anticancer research. 42(3)
Azoxystrobin (AZOX), a methoxyacrylate derivative, has potent antimicrobial and antitumor activities. Here, we report the anticancer effects of AZOX on the p53-negative human myelogenous leukemia cell line HL-60RG and the p53 positive human T-cell le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f894d960295e8e9b98f4f6337ade0dcc
https://pubmed.ncbi.nlm.nih.gov/35220221
https://pubmed.ncbi.nlm.nih.gov/35220221
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 1, Pp 69-77 (2009)
Abstract.: Macrolides are a well-known family of oral antibiotics whose antibacterial spectrum of activity covers most relevant bacterial species responsible for respiratory infectious disease. In recent years, it has been reported that macrolides ha
Externí odkaz:
https://doaj.org/article/0818018b96f345b4a804b24dd000efca
Autor:
Yuta, Semba, Shintaro, Yamamoto, Shunsuke, Takahashi, Takahisa, Shinomiya, Yukitoshi, Nagahara
Publikováno v:
European Journal of Pharmacology. 931:175183
Tumor-specific growth signal inhibition is a major anticancer strategy. Receptor tyrosine kinases (RTKs) are the most upstream receptors for growth signaling in cancer. Therefore, inhibition of RTKs has been proposed as an efficient therapeutic targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8933a8b05566393db0ea4b751be62be
https://doi.org/10.1016/j.ejphar.2022.175183
https://doi.org/10.1016/j.ejphar.2022.175183
Autor:
Isamu Shiina, Natsumi Shibata, Takumi Iwasawa, Takahisa Shinomiya, Nozomi Ota, Kenya Nakata, Yukitoshi Nagahara
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:401-410
Ridaifen (RID)-B is an analog derived from tamoxifen (TAM). TAM has an antitumor effect by acting as an antagonist to estrogen receptor (ER). However, TAM is known to also induces apoptosis in cancer cells that do not have ER. We clarified that RID-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8848c670a7d2c8fa1cb84824d9867aa
https://doi.org/10.1248/bpb.b18-00643
https://doi.org/10.1248/bpb.b18-00643
Publikováno v:
Exp Ther Med
Breast cancer susceptibility gene 1 (BRCA1)-associated protein 2 (BRAP2) is a novel protein that binds to BRCA1 and is located in the cytoplasm. BRAP2 has been demonstrated to bind to regulators of the Ras-Raf-MEK and PI3K/Akt pathways, both of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa302b24961a8b0cb13bd49be2edbf1a
https://doi.org/10.3892/etm.2021.9894
https://doi.org/10.3892/etm.2021.9894
Publikováno v:
3 Biotech. 10
Ranunculus ternatus is a traditional Chinese medicine with an anticancer effect, but its underlying mechanism is unknown. In this study, we demonstrated by MTT assay that ethyl acetate extract (RTE) from R. ternatus exerts cytotoxic effects on human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ff27bdbbfc4fca0e53b75a8ebe79dba
https://doi.org/10.1007/s13205-020-2111-z
https://doi.org/10.1007/s13205-020-2111-z
Publikováno v:
3 Biotech
Ranunculus ternatus is a traditional Chinese medicine with an anticancer effect, but its underlying mechanism is unknown. In this study, we demonstrated by MTT assay that ethyl acetate extract (RTE) from R. ternatus exerts cytotoxic effects on human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5e09729c4576435dbc6e429877ab593
https://pubmed.ncbi.nlm.nih.gov/32123647
https://pubmed.ncbi.nlm.nih.gov/32123647
Publikováno v:
Cell Biology International. 38:381-387
Embryonic stem (ES) cells are derived from the inner cell mass of blastocysts and have a pluripotency to differentiate into a variety of cell types. ES cells have high resistance to environmental stress compared to functional cells, which can undergo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b6efbbacc7721ca657635035c5e428b
https://doi.org/10.1002/cbin.10214
https://doi.org/10.1002/cbin.10214
Autor:
Yuriko Sekine, Yukitoshi Nagahara, Eiji Suzuki, Takahisa Shinomiya, Masahiko Ikekita, Hiromi Uchiro, Yoji Yoshimi
Publikováno v:
European Journal of Pharmacology. 694:53-59
β-Methoxyacrylate antibiotics are well known to inhibit the fungal and yeast mitochondrial respiratory chain. In addition, β-methoxyacrylates are reported to suppress the proliferation of mammalian cancer cells. Differentiation and cell-cycle arres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e06f70a9733a2208c1ee0f972597f2
https://doi.org/10.1016/j.ejphar.2012.08.018
https://doi.org/10.1016/j.ejphar.2012.08.018
Autor:
Yoji Yoshimi, Hidekazu Tamegai, Mami Hitokuwada, Takahisa Shinomiya, Taome Nagamori, Yukitoshi Nagahara, Masahiko Ikekita
Publikováno v:
BioFactors. 37:447-454
Inulin is a polysaccharide that enhances various immune responses, mainly to T and B cells, natural killer cells, and macrophages in vivo and in vitro. Previous reports describe that inulin activates macrophages indirectly by affecting the alternativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efd57092a0ea213f96c68135920397b
https://doi.org/10.1002/biof.186
https://doi.org/10.1002/biof.186