Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Takahisa, SHINOMIYA"'
Publikováno v:
Anticancer research. 42(3)
Azoxystrobin (AZOX), a methoxyacrylate derivative, has potent antimicrobial and antitumor activities. Here, we report the anticancer effects of AZOX on the p53-negative human myelogenous leukemia cell line HL-60RG and the p53 positive human T-cell le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f894d960295e8e9b98f4f6337ade0dcc
https://pubmed.ncbi.nlm.nih.gov/35220221
https://pubmed.ncbi.nlm.nih.gov/35220221
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 1, Pp 69-77 (2009)
Abstract.: Macrolides are a well-known family of oral antibiotics whose antibacterial spectrum of activity covers most relevant bacterial species responsible for respiratory infectious disease. In recent years, it has been reported that macrolides ha
Externí odkaz:
https://doaj.org/article/0818018b96f345b4a804b24dd000efca
Autor:
Yuta, Semba, Shintaro, Yamamoto, Shunsuke, Takahashi, Takahisa, Shinomiya, Yukitoshi, Nagahara
Publikováno v:
European Journal of Pharmacology. 931:175183
Tumor-specific growth signal inhibition is a major anticancer strategy. Receptor tyrosine kinases (RTKs) are the most upstream receptors for growth signaling in cancer. Therefore, inhibition of RTKs has been proposed as an efficient therapeutic targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8933a8b05566393db0ea4b751be62be
https://doi.org/10.1016/j.ejphar.2022.175183
https://doi.org/10.1016/j.ejphar.2022.175183
Autor:
Isamu Shiina, Natsumi Shibata, Takumi Iwasawa, Takahisa Shinomiya, Nozomi Ota, Kenya Nakata, Yukitoshi Nagahara
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:401-410
Ridaifen (RID)-B is an analog derived from tamoxifen (TAM). TAM has an antitumor effect by acting as an antagonist to estrogen receptor (ER). However, TAM is known to also induces apoptosis in cancer cells that do not have ER. We clarified that RID-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8848c670a7d2c8fa1cb84824d9867aa
https://doi.org/10.1248/bpb.b18-00643
https://doi.org/10.1248/bpb.b18-00643
Publikováno v:
Exp Ther Med
Breast cancer susceptibility gene 1 (BRCA1)-associated protein 2 (BRAP2) is a novel protein that binds to BRCA1 and is located in the cytoplasm. BRAP2 has been demonstrated to bind to regulators of the Ras-Raf-MEK and PI3K/Akt pathways, both of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa302b24961a8b0cb13bd49be2edbf1a
https://doi.org/10.3892/etm.2021.9894
https://doi.org/10.3892/etm.2021.9894
Publikováno v:
3 Biotech. 10
Ranunculus ternatus is a traditional Chinese medicine with an anticancer effect, but its underlying mechanism is unknown. In this study, we demonstrated by MTT assay that ethyl acetate extract (RTE) from R. ternatus exerts cytotoxic effects on human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ff27bdbbfc4fca0e53b75a8ebe79dba
https://doi.org/10.1007/s13205-020-2111-z
https://doi.org/10.1007/s13205-020-2111-z
Autor:
Kei Kawakami, Yukitoshi Nagahara, Abudubari Sikandan, Takahisa Shinomiya, Daiki Yagi, Ryo Nishikawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 41:743-748
Sphingolipids are putative intracellular signal mediators in cell differentiation, growth inhibition, and apoptosis. Especially, sphingoid base-backbones of sphingolipids (sphingosine, sphinganine, and phytosphingosine) and their metabolites N-acyl-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e256bd3db4542984a80c9b04728596f7
https://doi.org/10.1248/bpb.b17-00926
https://doi.org/10.1248/bpb.b17-00926
Publikováno v:
3 Biotech
Ranunculus ternatus is a traditional Chinese medicine with an anticancer effect, but its underlying mechanism is unknown. In this study, we demonstrated by MTT assay that ethyl acetate extract (RTE) from R. ternatus exerts cytotoxic effects on human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5e09729c4576435dbc6e429877ab593
https://pubmed.ncbi.nlm.nih.gov/32123647
https://pubmed.ncbi.nlm.nih.gov/32123647
Publikováno v:
International journal of molecular medicine. 42(1)
A paste composed of the boiled leaves and roots of the Ashwagandha plant is used to cure ulcer and swelling in Ayurvedic medicine. However, the effects of the hot water extract of Ashwagandha roots (ASH‑WEX), which is also used in Ayurveda, on skin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81420b7a934e4471972ac82588251709
https://pubmed.ncbi.nlm.nih.gov/29620265
https://pubmed.ncbi.nlm.nih.gov/29620265
Publikováno v:
Anticancer research. 37(4)
Background Mitochondria are central to apoptosis. However, apoptosis progression involving mitochondria is not fully understood. A factor involved in mitochondria-mediated apoptosis is 7A6 antigen. 7A6 localizes to mitochondria from the cytosol durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81febd723def4c6ff11d34e6e8a4509d
https://pubmed.ncbi.nlm.nih.gov/28373431
https://pubmed.ncbi.nlm.nih.gov/28373431