Zobrazeno 1 - 10
of 752
pro vyhledávání: '"Takahiro Seki"'
Autor:
Kensuke Motomura, Erika Ueda, Alex Boateng, Masaharu Sugiura, Keiichi Kadoyama, Natsuko Hitora-Imamura, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Aromatic (Ar)-turmerone is a bioactive component of turmeric oil obtained from Curcuma longa. We recently identified a novel analog (A2) of ar-turmerone that protects dopaminergic neurons from toxic stimuli by activating nuclear factor
Externí odkaz:
https://doaj.org/article/d9db6cc762ad412d96ad6591a73bf799
Publikováno v:
Science and Technology of Advanced Materials, Vol 25, Iss 1 (2024)
ABSTRACTIn recent times, there has been a significant surge in research interest surrounding thermo-responsive water-soluble polyacrylamides, primarily due to their intriguing capability to undergo significant solubility changes in water. These polym
Externí odkaz:
https://doaj.org/article/0175fb56c3474702a38ea1c8641006d5
Autor:
Keita Kinoshita, Kensuke Motomura, Keisuke Ushida, Yuma Hirata, Ayumu Konno, Hirokazu Hirai, Shunsuke Kotani, Natsuko Hitora-Imamura, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki
Publikováno v:
Neurotherapeutics, Vol 21, Iss 4, Pp e00370- (2024)
Hemorrhage-induced injury of the corticospinal tract (CST) in the internal capsule (IC) causes severe neurological dysfunction in both human patients and rodent models of intracerebral hemorrhage (ICH). A nuclear receptor Nurr1 (NR4A2) is known to ex
Externí odkaz:
https://doaj.org/article/5ca566014b614774ad88d7de781b319a
Autor:
Xiaoting Sun, Wenhai Sui, Zepeng Mu, Sisi Xie, Jinxiu Deng, Sen Li, Takahiro Seki, Jieyu Wu, Xu Jing, Xingkang He, Yangang Wang, Xiaokun Li, Yunlong Yang, Ping Huang, Minghua Ge, Yihai Cao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion, and metastasis. However, the impact of global adipose metabolism on tumor growth and the dru
Externí odkaz:
https://doaj.org/article/54641af618e04937ac74aa62987f1d54
Autor:
Sizhe Liu, Kenta Watanabe, Eiji Miwa, Mitsuo Hara, Takahiro Seki, Koichi Mayumi, Kohzo Ito, Yukikazu Takeoka
Publikováno v:
Giant, Vol 17, Iss , Pp 100224- (2024)
The modification of vinyl groups on polyrotaxane derivatives, obtained with polyethylene glycol as the axial molecule and α-cyclodextrin as the cyclic molecule, allows the production of crosslinkers that react with various monomers, facilitating the
Externí odkaz:
https://doaj.org/article/76e48897bc404190b57c0342826c49c2
Autor:
Hideki Iwamoto, Hiroyuki Suzuki, Atsutaka Masuda, Takahiko Sakaue, Toru Nakamura, Toshimitsu Tanaka, Miwa Sakai, Yasuko Imamura, Hirohisa Yano, Takuji Torimura, Hironori Koga, Kaori Yasuda, Masakatsu Tsurusaki, Takahiro Seki, Takumi Kawaguchi
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108797- (2024)
Summary: Current approved anti-angiogenic drugs (AAD) for hepatocellular carcinoma (HCC) inhibit tumor angiogenesis, but affect the hepatic vasculature resulting in adverse effects. Tumor endothelial cells (TECs) differ from normal endothelial cells.
Externí odkaz:
https://doaj.org/article/031aaec1a390453d82be69fc0ff3cd30
Autor:
Akiko Idera, Lisa M. Sharkey, Yuki Kurauchi, Keiichi Kadoyama, Henry L. Paulson, Hiroshi Katsuki, Takahiro Seki
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 3, Pp 182-192 (2023)
Missense mutations of ubiquilin 2 (UBQLN2) have been identified to cause X-linked amyotrophic lateral sclerosis (ALS). Proteasome-mediated protein degradation is reported to be impaired by ALS-associated mutations of UBQLN2. However, it remains unkno
Externí odkaz:
https://doaj.org/article/2b339b24852d4d43bfeecbc6295ec171
Autor:
Kayoko Hosaka, Chenchen Wang, Shiyue Zhang, Xue Lv, Takahiro Seki, Yin Zhang, Xu Jing, Jieyu Wu, Qiqiao Du, Xingkang He, Yulong Fan, Xuan Li, Makoto Kondo, Masahito Yoshihara, Hong Qian, Lihong Shi, Ping Zhu, Yuanfu Xu, Yunlong Yang, Tao Cheng, Yihai Cao
Publikováno v:
Cancer Communications, Vol 43, Iss 6, Pp 637-660 (2023)
Abstract Background Tumors possess incessant growth features, and expansion of their masses demands sufficient oxygen supply by red blood cells (RBCs). In adult mammals, the bone marrow (BM) is the main organ regulating hematopoiesis with dedicated m
Externí odkaz:
https://doaj.org/article/8df481223bdb46a19afced0251c70f02
Autor:
Hiroyuki Suzuki, Hideki Iwamoto, Takahiro Seki, Toru Nakamura, Atsutaka Masuda, Takahiko Sakaue, Toshimitsu Tanaka, Yasuko Imamura, Takashi Niizeki, Masahito Nakano, Shigeo Shimose, Tomotake Shirono, Yu Noda, Naoki Kamachi, Miwa Sakai, Kazutoyo Morita, Masamichi Nakayama, Tomoharu Yoshizumi, Ryoko Kuromatsu, Hirohisa Yano, Yihai Cao, Hironori Koga, Takuji Torimura
Publikováno v:
Cancer Communications, Vol 43, Iss 4, Pp 415-434 (2023)
Abstract Background Antiangiogenic tyrosine kinase inhibitors (TKIs) provide one of the few therapeutic options for effective treatment of hepatocellular carcinoma (HCC). However, patients with HCC often develop resistance toward antiangiogenic TKIs,
Externí odkaz:
https://doaj.org/article/b014bbfe6ace4455a5688b7b5212c659
Autor:
Yusei Yamada, Madoka Fukaura‐Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 8, Pp n/a-n/a (2023)
Abstract Background Niemann–Pick disease type C (NPC) is a fatal neurodegenerative disorder caused by abnormal intracellular cholesterol trafficking. Cyclodextrins (CDs), the most promising therapeutic candidates for NPC, but with concerns about ot
Externí odkaz:
https://doaj.org/article/4e90738b28c44e4c9ddaf53a1c5805b3