Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Takahiro Murozono"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:4225-4234
A series of 4-amino-5-chloro-2-methoxy- N -(piperidin-4-ylmethyl)benzamide derivatives bearing an aralkylamino, alkylamino, benzoyl or phenylsulfonyl group at its side chain part at the 1-position on the piperidine ring was synthesized. They were eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7119f42a3d7778509b2fe16fcc02c38b
https://doi.org/10.1016/s0968-0896(03)00412-7
https://doi.org/10.1016/s0968-0896(03)00412-7
Autor:
Takahiro Murozono, Masatsugu Hori, Toshiki Moriyama, Katsuyuki Nagatoya, Susumu Oseto, Akio Ando, Noritaka Kawada, Masanobu Takeji, Enyu Imai
Publikováno v:
Kidney International. 61:1684-1695
Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction. Background The small GTPase Rho is involved in cell-to-substratum adhesion and cell contraction. These actions of Rho mediated by downstream Rho effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d76d302ed3cee20151401b9b2486fe
https://doi.org/10.1046/j.1523-1755.2002.00328.x
https://doi.org/10.1046/j.1523-1755.2002.00328.x
Autor:
Takayuki Ishige, Hiroyuki Kishida, Sumie Sekiguchi, Yoshihito Tanaka, Yuji Abe, Yoshinobu Nakamaru, Ikuko Miyaguchi, Hiroshi Kitajima, Keigo Kosaka, Kumiko Yoshida, Reiko Tsutsumiuchi, Naoko Ueda, Mika Nabeno, Masahiro Takeuchi, Shinichi Ishii, Yoko Takashina, Hiroyuki Utsumi, Tomohiro Yoshida, Satoko Kiuchi, Yoshiharu Hayashi, Kyoko Shima, Shuji Sonda, Aki Soejima, Naoya Masutomi, Jun Anabuki, Fukuda Sayaka, Hiroshi Sakashita, Mitsuharu Nakamura, Takahiro Murozono, Fumihiko Akahoshi
Publikováno v:
Bioorganicmedicinal chemistry. 20(19)
Dipeptidyl peptidase IV (DPP-4) inhibition is suitable mechanism for once daily oral dosing regimen because of its low risk of hypoglycemia. We explored linked bicyclic heteroarylpiperazines substituted at the γ-position of the proline structure in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886f16383bee6e2ced6da2f121e178d6
https://pubmed.ncbi.nlm.nih.gov/22959556
https://pubmed.ncbi.nlm.nih.gov/22959556
Autor:
Kunio Dobashi, Kunihiko Iizuka, Hideo Tsukagoshi, Takahiro Murozono, Yasuo Shimizu, Tsugio Nakazawa, Masatomo Mori, Takashi Harada, Akihiro Yoshii
Publikováno v:
European journal of pharmacology. 406(2)
To evaluate (+)-(R)-trans-4-(l-Aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride, monohydrate (Y-27632), a selective Rho-kinase inhibitor, as a novel bronchodilator in vivo and in vitro, we investigated the effect of Y-27632 on the ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4455a4c9f34855e870edfdf3fc1dc1
https://pubmed.ncbi.nlm.nih.gov/11020491
https://pubmed.ncbi.nlm.nih.gov/11020491