Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Takahiro Fukuroda"'
Autor:
Yasuyuki Ishii, Hiroshi Miyazoe, Akio Ohno, Takeshi Tanaka, Takanobu Mochidome, Hirobumi Takahashi, Mioko Hirayama, Hiroshi Kawamoto, Kiyoshi Tadano, Masanori Asai, Izumi Yamamoto, Takashi Yoshizumi, Tetsuya Kato, Kensuke Kobayashi, Takahiro Fukuroda, Takeshi Tani, Osamu Okamoto, Minaho Uchiyama, Hiroshi Nakashima, Satoshi Ozaki, Satoru Ito, Hisashi Ohta, Atsushi Shimizu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3096-3099
The synthesis and biological evaluation of new potent opioid receptor-like 1 (ORL1) antagonists are presented. Conversion of the thioether linkage of the prototype [It is reported prior to this communication as a consecutive series.: Kobayashi, K.; K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d5603a2c25957b416dfab9912d650c
https://doi.org/10.1016/j.bmcl.2009.04.023
https://doi.org/10.1016/j.bmcl.2009.04.023
Autor:
Masahiro Katoh, Tadahiro Nambu, Takahiro Fukuroda, Takumi Sakai, Sayuri Uehara, Masaru Nishikibe
Publikováno v:
Biochemical and Biophysical Research Communications. 384:173-179
Patients with diabetes are under a hypercoagulable state leading to generation of thrombin. It is not known whether thrombin plays a role in the progression of diabetic nephropathy. We analyzed gene expression of two thrombin receptors, protease-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee27e74af23236e374a8e4188da432a
https://doi.org/10.1016/j.bbrc.2009.04.105
https://doi.org/10.1016/j.bbrc.2009.04.105
Autor:
Takeshi Tani, Hisashi Ohta, Tetsuya Kato, Tomohiro Tsujita, Hirobumi Takahashi, Hirokatsu Ito, Mioko Hirayama, Kiyoshi Tadano, Tomoko Azuma-Kanoh, Hiroshi Kawamoto, Masato Chiba, Daisuke Ichikawa, Osamu Okamoto, Yuichi Sugimoto, Takahiro Fukuroda, Yoshihiro Shibata, Satoshi Ozaki, Takashi Yoshizumi, Shoki Okuda, Hiroshi Miyazoe, Yasuyuki Ishii
Publikováno v:
Journal of Medicinal Chemistry. 51:4021-4029
A series of compounds based on 7-{[4-(2-methylphenyl)piperidin-1-yl]methyl}-6,7,8,9-tetrahydro-5 H-cyclohepta[ b]pyridine-9-ol ( (-)-8b), a potent and selective opioid receptor-like 1 (ORL1) antagonist, was prepared and evaluated using structure-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa95ff00803877c55c3b060f9e68e8b9
https://doi.org/10.1021/jm701590h
https://doi.org/10.1021/jm701590h
Autor:
Xiao-Ming Guan, Osamu Okamoto, Takahiro Fukuroda, Tomoyuki Ohe, Nagaaki Sato, Akira Gomori, Takehiro Fukami, Masaru Nishikibe, Yuko Mitobe, Hiroko Matsushita, Masaki Ihara, Lex M.T. Van Der Ploeg, Akio Kanatani, Naomi Murai, Hisashi Iwaasa, Masayasu Hidaka, Shin Ichiro Egashira, Takeshi Tanaka, Douglas J. MacNeil, Makoto Jitsuoka, Yasuyuki Ishii, Satoshi Mashiko, Akane Ishihara, Takashi Murai
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7154-7158
Neuropeptide Y (NPY) is thought to have a major role in the physiological control of energy homeostasis. Among five NPY receptors described, the NPY Y5 receptor (Y5R) is a prime candidate to mediate some of the effects of NPY on energy homeostasis, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c396bd3e0ef862e30735347a3d9b593
https://doi.org/10.1073/pnas.0510320103
https://doi.org/10.1073/pnas.0510320103
Publikováno v:
Journal of Cardiovascular Pharmacology. 44:S350-S353
To clarify the functional role ofendothelin-A/endothelin-B (ET A /ET B ) receptors in congestive heart failure (CHF), we examined the effects of a non-selective endothelin receptor agonist, endothelin-1 (ET-1), and a selective ET B receptor agonist,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f17de225a082d0b231740d10995ef87
https://doi.org/10.1097/01.fjc.0000166291.72324.eb
https://doi.org/10.1097/01.fjc.0000166291.72324.eb
Autor:
Satoshi Ozaki, Toshio Nagase, Takahiro Fukuroda, Kazuhito Noguchi, Kasumi Katsuki, Kiyofumi Ishikawa, Kenji Niiyama, Takashi Hayama, Akihiro Hisaka, Masaki Ihara, Akira Naya, Hirobumi Takahashi, Satoshi Ito, Toshiaki Mase, Masaru Nishikibe, Mitsuo Yano
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:2461-2470
Compounds ( 2 – 5 ) with a 6-carboxy-5,7-diarylcyclopentenopyridine skeleton were designed, synthesized, and identified as a new class of potent non-peptide endothelin receptor antagonists. The regio-isomer 2 was found to show potent inhibitory act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::803b4268fea1f0b8ead733d4ca8c3f29
https://doi.org/10.1016/s0968-0896(02)00122-0
https://doi.org/10.1016/s0968-0896(02)00122-0
Autor:
Yasuyuki Ishii, Tetsuya Kanno, Maki Kanesaka, Satoshi Mashiko, Masaki Ihara, Akane Ishihara, Mikiko Hata, Masahiko Kobayashi, Yushin Tominaga, Megumu Okada, Takehiro Fukami, Takashi Murai, Takeshi Tanaka, Keiko Watanabe, Akio Kanatani, Akira Gomori, Masayasu Hidaka, Takahiro Fukuroda, Nagaaki Sato
Publikováno v:
British Journal of Pharmacology. 136:341-346
An experiment was conducted to examine whether a potent, orally active and highly selective neuropeptide Y Y1 receptor antagonist attenuates hyperphagia and obesity in genetically obese Zucker fatty rats. Oral administration of the Y1 antagonist (30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a87d1e9e3c6876d145569ef7f8f48d8
https://doi.org/10.1038/sj.bjp.0704696
https://doi.org/10.1038/sj.bjp.0704696
Autor:
Takahiro Fukuroda, Tomoyuki Ohe, Naomi Murai, Yuji Haga, Akane Ishihara, Yasuyuki Ishii, Tetsuya Kanno, Satoshi Mashiko, Osamu Okamoto, Akio Kanatani, Masaki Ihara, Mikiko Hata, Takehiro Fukami
Publikováno v:
Molecular Pharmacology. 59:501-505
Neuropeptide Y (NPY) is a potent feeding stimulant. The orexigenic effect of NPY might be caused in part by the action of Y1 receptors. However, the existence of multiple NPY receptors including a possible novel feeding receptor has made it difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a827dcdcaeaa779302beb4a8e215ca
https://doi.org/10.1124/mol.59.3.501
https://doi.org/10.1124/mol.59.3.501
Autor:
Van der Ploeg Lh, Junko Ito, Masaki Ihara, Satoshi Mashiko, Nishimura S, Takehiro Fukami, Sugimoto N, Naomi Murai, Akio Kanatani, Nancy R. Morin, Saga Y, Douglas J. MacNeil, Takahiro Fukuroda
Publikováno v:
Endocrinology. 141:1011-1016
Neuropeptide Y (NPY) increases food intake through the action of hypothalamic NPY receptors. At least six subtypes of NPY, peptide YY (PYY), and pancreatic polypeptide (PP) receptors have been identified in mice. Although the involvement of Y1 and Y5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312e33064256c2be47c877cb758ccd59
https://doi.org/10.1210/endo.141.3.7387
https://doi.org/10.1210/endo.141.3.7387
Autor:
Akio Kanatani, Masaki Ihara, Takehiro Fukami, Yoshimi Tsuchiya, Takeshi Tanaka, Mikiko Hata, Tetsuya Kanno, Takahiro Fukuroda, Akane Ishihara, Aya Sakuraba, Toshiaki Mase
Publikováno v:
Biochemical and Biophysical Research Communications. 266:88-91
Neuropeptide Y (NPY) is known to induce robust feeding through the action of NPY receptors in the hypothalamus. Among the subtypes of NPY receptors, Y(1) receptors may play a key role in feeding regulation. In the present study, we demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d04f7c64416b750090c7c48ea9265e2
https://doi.org/10.1006/bbrc.1999.1750
https://doi.org/10.1006/bbrc.1999.1750