Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Takahiro Fukazawa"'
Autor:
Masato Kojima, Takanori Harada, Takahiro Fukazawa, Sho Kurihara, Isamu Saeki, Shinya Takahashi, Eiso Hiyama
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Single-cell sequencing of circulating tumor cells can precisely represent tumor heterogeneity and provide useful information for cancer treatment and research. After spiking TGW neuroblastoma cells into blood derived from healthy volunteer,
Externí odkaz:
https://doaj.org/article/8ca0c1b239af4bb3ae012c967c0c0408
Autor:
Keiji Tanimoto, Kiichi Hirota, Takahiro Fukazawa, Yoshiyuki Matsuo, Toshihito Nomura, Nazmul Tanuza, Nobuyuki Hirohashi, Hidemasa Bono, Takemasa Sakaguchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2. Although cigarette smoke is gene
Externí odkaz:
https://doaj.org/article/cadfc18f87f14c8381e5f00ac64ea3be
Autor:
Maryami Yuliana Kosim, Takahiro Fukazawa, Mutsumi Miyauchi, Nobuyuki Hirohashi, Keiji Tanimoto
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Lactoferrin (LF) is an iron binding glycoprotein of the transferrin family with a wide spectrum of biological effects, including anti-cancer activity. However, the detailed molecular mechanisms of anti-cancer activity of LF have not been fully determ
Externí odkaz:
https://doaj.org/article/2d61e3fb5b094dd2856fbbbdc1ceeb18
Publikováno v:
Cells, Vol 11, Iss 19, p 3171 (2022)
We previously used microarrays to show that high expression of DHRS3, NROB1, and CYP26A1 predicts favorable NB outcomes. Here, we investigated whether expression of these genes was associated with suppression of NB cell (SK-N-SH, NB12, and TGW) growt
Externí odkaz:
https://doaj.org/article/4e7072f86bdc473aab2ca19c38001875
Autor:
Kiichi Shimabukuro, Takahiro Fukazawa, Akinori Kanai, Hidehiko Kawai, Kengo Mekata, Nobuyuki Hirohashi, Naoya Kakimoto, Keiji Tanimoto
Publikováno v:
Cells, Vol 11, Iss 3, p 501 (2022)
The biological effects of low-dose-rate (LDR) radiation exposure in nuclear power plant accidents and medical uses of ionizing radiation (IR), although being a social concern, remain unclear. In this study, we evaluated the effects of LDR-IR on globa
Externí odkaz:
https://doaj.org/article/74d507214f714bd095df23a352617082
Autor:
Takahiro Fukazawa, Keiji Tanimoto, Looniva Shrestha, Takeshi Imura, Shinya Takahashi, Taijiro Sueda, Nobuyuki Hirohashi, Eiso Hiyama, Louis Yuge
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219363 (2019)
Although the biological systems in the human body are affected by the earth's gravity, information about the underlying molecular mechanisms is limited. For example, apoptotic signaling is enhanced in cancer cells subjected to microgravity. We reason
Externí odkaz:
https://doaj.org/article/d625784dd4ff4af7a18eaa9388ee9b81
Autor:
Masato Kojima, Takanori Harada, Takahiro Fukazawa, Sho Kurihara, Ryo Touge, Isamu Saeki, Shinya Takahashi, Eiso Hiyama
Publikováno v:
Cancer science.
Circulating tumor cells (CTCs) derived from any tumor tissue could contribute to metastasis and resistance to cancer treatments. In this study, we performed single-cell next-generation sequencing of CTCs and evaluated usefulness for characterizing tu
Autor:
Takahiro Fukazawa, Keiji Tanimoto, Emi Yamaoka, Masato Kojima, Masami Kanawa, Nobuyuki Hirohashi, Eiso Hiyama
Publikováno v:
Cancers; Volume 14; Issue 19; Pages: 4732
Outcomes of pediatric hepatoblastoma (HBL) have improved, but refractory cases still occur. More effective and safer drugs are needed that are based on molecular mechanisms. A disintegrin and metalloproteases (ADAMs) are expressed with high frequency
Autor:
Hidemasa Bono, Nobuyuki Hirohashi, Keiji Tanimoto, Akinori Kanai, Hideaki Nakamura, Hidetaka Eguchi, Hiromasa Ono, Takahiro Fukazawa, Kazumi Shimamoto
Publikováno v:
Carcinogenesis. 41:1184-1194
We previously demonstrated that expression of a Krüppel-like zinc finger transcription factor, GLIS1, dramatically increases under hypoxic conditions via a transcriptional mechanism induced by HIF-2α cooperating with AP-1 members. In this study, we
Autor:
Toshihito Nomura, Takahiro Fukazawa, Hidemasa Bono, Takemasa Sakaguchi, Nobuyuki Hirohashi, Nazmul Tanuza, Kiichi Hirota, Yoshiyuki Matsuo, Keiji Tanimoto
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2. Although cigarette smoke is generally bel