Zobrazeno 1 - 10
of 851
pro vyhledávání: '"Takahiro Ochiya"'
Autor:
Yu Fujita, Tsukasa Kadota, Reika Kaneko, Yuta Hirano, Shota Fujimoto, Naoaki Watanabe, Ryusuke Kizawa, Takashi Ohtsuka, Kazuyoshi Kuwano, Takahiro Ochiya, Jun Araya
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Acute lung injury (ALI) is characterized by respiratory failure resulting from the disruption of the epithelial and endothelial barriers as well as immune system. In this study, we evaluated the therapeutic potential of airway epithelial cel
Externí odkaz:
https://doaj.org/article/3f232368bcd5464db8bf088406cf5fc6
Autor:
Mayu Yoshida, Juntaro Matsuzaki, Koji Fujita, Masamichi Kimura, Tomohiro Umezu, Noi Tokuda, Tomoko Yamaguchi, Masahiko Kuroda, Takahiro Ochiya, Yoshimasa Saito, Kiminori Kimura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract There is an unmet need for antifibrotic therapies to prevent the progression of liver cirrhosis. Previously, we conducted an exploratory trial to assess the safety and antifibrotic efficacy of PRI-724, a selective CBP/β-catenin inhibitor, i
Externí odkaz:
https://doaj.org/article/e973a4feb8e641d6a1cfb726a0e430a8
Autor:
Marta Prieto‐Vila, Yusuke Yoshioka, Naoya Kuriyama, Akihiko Okamura, Yusuke Yamamoto, Asao Muranaka, Takahiro Ochiya
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 7, Pp n/a-n/a (2024)
Abstract Cardiac fibrosis is a common pathological feature of cardiovascular diseases that arises from the hyperactivation of fibroblasts and excessive extracellular matrix (ECM) deposition, leading to impaired cardiac function and potentially heart
Externí odkaz:
https://doaj.org/article/40439a8295c6445f984e34c47ae3c851
Autor:
Tomohiro Umezu, Shogo Tanaka, Shoji Kubo, Masaru Enomoto, Akihiro Tamori, Takahiro Ochiya, Y.‐H. Taguchi, Masahiko Kuroda, Yoshiki Murakami
Publikováno v:
Cancer Reports, Vol 7, Iss 2, Pp n/a-n/a (2024)
Abstract Background and Aim Circulating micro RNAs (miRNAs) indicate clinical pathologies such as inflammation and carcinogenesis. In this study, we aimed to investigate whether miRNA expression level patterns in could be used to diagnose hepatocellu
Externí odkaz:
https://doaj.org/article/5f70bdf7163b49919fc52a1724c7ad25
Autor:
Joshua A. Welsh, Deborah C. I. Goberdhan, Lorraine O'Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Juan M. Falcon‐Perez, Qing‐Ling Fu, Andrew F. Hill, Metka Lenassi, Sai Kiang Lim, Mỹ G. Mahoney, Sujata Mohanty, Andreas Möller, Rienk Nieuwland, Takahiro Ochiya, Susmita Sahoo, Ana C. Torrecilhas, Lei Zheng, Andries Zijlstra, Sarah Abuelreich, Reem Bagabas, Paolo Bergese, Esther M. Bridges, Marco Brucale, Dylan Burger, Randy P. Carney, Emanuele Cocucci, Rossella Crescitelli, Edveena Hanser, Adrian L. Harris, Norman J. Haughey, An Hendrix, Alexander R. Ivanov, Tijana Jovanovic‐Talisman, Nicole A. Kruh‐Garcia, Vroniqa Ku'ulei‐Lyn Faustino, Diego Kyburz, Cecilia Lässer, Kathleen M. Lennon, Jan Lötvall, Adam L. Maddox, Elena S. Martens‐Uzunova, Rachel R. Mizenko, Lauren A. Newman, Andrea Ridolfi, Eva Rohde, Tatu Rojalin, Andrew Rowland, Andras Saftics, Ursula S. Sandau, Julie A. Saugstad, Faezeh Shekari, Simon Swift, Dmitry Ter‐Ovanesyan, Juan P. Tosar, Zivile Useckaite, Francesco Valle, Zoltan Varga, Edwin van derPol, Martijn J. C. vanHerwijnen, Marca H. M. Wauben, Ann M. Wehman, Sarah Williams, Andrea Zendrini, Alan J. Zimmerman, MISEV Consortium, Clotilde Théry, Kenneth W. Witwer
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 2, Pp n/a-n/a (2024)
Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have gene
Externí odkaz:
https://doaj.org/article/62d9f58d0f2b47e292d51b7893a73080
Autor:
Nobutaka Takeda, Atsunori Tsuchiya, Masaki Mito, Kazuki Natsui, Yui Natusi, Yohei Koseki, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Hiroyuki Abe, Masayuki Sano, Taketomo Kido, Yusuke Yoshioka, Junichi Kikuta, Tohru Itoh, Ken Nishimura, Masaru Ishii, Takahiro Ochiya, Atsushi Miyajima, Shuji Terai
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-14 (2023)
Abstract Background The progression of liver fibrosis leads to portal hypertension and liver dysfunction. However, no antifibrotic agents have been approved for cirrhosis to date, making them an unmet medical need. Small extracellular vesicles (sEVs)
Externí odkaz:
https://doaj.org/article/33ffc1abeeee43bea1671cd58272c823
Autor:
Kagenori Ito, Tomofumi Yamamoto, Yusuke Hayashi, Shun Sato, Jun Nakayama, Fumihiko Urabe, Takeo Shimasaki, Eijiro Nakamura, Yoshiyuki Matui, Hiroyuki Fujimoto, Takahiro Kimura, Shin Egawa, Takahiro Ochiya, Yusuke Yamamoto
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2147-2167 (2023)
Clinically, the osteolytic phenotype is rare in prostate cancer (PCa), and the prognosis is generally worse than that of the osteoblastic phenotype. Osteoblastic prostate cancer (BPCa) is a major type of bone metastasis. Several factors responsible f
Externí odkaz:
https://doaj.org/article/552f86d13f2e40149574c3164a08091a
Autor:
Tomohiro Umezu, Tomoya Mori, Hidenori Toyoda, Kohsuke Kanekura, Akihiro Tamori, Takahiro Ochiya, Masahiko Kuroda, Tatsuya Akutsu, Yoshiki Murakami
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7858 (2024)
Risk factors for hepatocarcinogenesis include chronic inflammation due to viral infection, liver fibrosis, and aging. In this study, we separated carcinogenic and non-carcinogenic cases due to hepatitis C virus (HCV) infection, aiming to comprehensiv
Externí odkaz:
https://doaj.org/article/4bfafbb05b2440c5a9661c926a7584cc
Autor:
Norihisa Ichinohe, Naoki Tanimizu, Keisuke Ishigami, Yusuke Yoshioka, Naoki Fujitani, Takahiro Ochiya, Motoko Takahashi, Toshihiro Mitaka
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Background Small hepatocyte-like progenitor cells (SHPCs) are hepatocytic progenitor cells that transiently form clusters in rat livers treated with retrorsine (Ret) that underwent 70% partial hepatectomy (PH). We previously reported that tr
Externí odkaz:
https://doaj.org/article/01027d70d36941d085c6de300533cc09
Publikováno v:
Frontiers in Human Neuroscience, Vol 17 (2023)
Breast cancer, which exhibits an increasing incidence and high mortality rate among cancers, is predominantly attributed to metastatic malignancies. Brain metastasis, in particular, significantly contributes to the elevated mortality in breast cancer
Externí odkaz:
https://doaj.org/article/e31981a8ba4744cfaf209284dd951d03