Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Takahiro, Kamio"'
Autor:
Kensei Yamaguchi, Yung-Jue Bang, Satoru Iwasa, Naotoshi Sugimoto, Min-Hee Ryu, Daisuke Sakai, Hyun Cheol Chung, Hisato Kawakami, Hiroshi Yabusaki, Jeeyun Lee, Tatsu Shimoyama, Keun-Wook Lee, Kaku Saito, Yoshinori Kawaguchi, Takahiro Kamio, Akihito Kojima, Masahiro Sugihara, Kohei Shitara
Publikováno v:
Journal of Clinical Oncology. 41:816-825
PURPOSE To investigate efficacy and safety of trastuzumab deruxtecan (T-DXd) in human epidermal growth factor receptor 2 (HER2)–low gastric or gastroesophageal junction (GEJ) adenocarcinoma. METHODS Patients with locally advanced or metastatic HER2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b635a45b7e777cde3581b657c6feb416
https://doi.org/10.1200/jco.22.00575
https://doi.org/10.1200/jco.22.00575
Autor:
Akihiko Shimomura, Toshimi Takano, Shunji Takahashi, Yasuaki Sagara, Junichiro Watanabe, Eriko Tokunaga, Tetsu Shinkai, Takahiro Kamio, Kunika Kikumori, Emi Kamiyama, Yoshihiko Fujisaki, Dan Saotome, Toshinari Yamashita
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:160-169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5a27284cedf1cbdb5aaf750cec11ea1
https://doi.org/10.1002/cpt.2757
https://doi.org/10.1002/cpt.2757
Publikováno v:
Folia Pharmacologica Japonica. 156:47-51
Antibody-drug conjugates (ADCs) combine the specific antibody and cytotoxic agent by a linker and represent a promising drug class with a wider therapeutic window than conventional chemotherapeutic agents by substantiating efficient and specific drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb8a7438450ede43673503e32fe4bad6
https://doi.org/10.1254/fpj.20076
https://doi.org/10.1254/fpj.20076
Autor:
Kohei Shitara, Hisato Kawakami, Jeeyun Lee, DESTINY-Gastric Investigators, Hyun-Cheol Chung, Akihito Kojima, Daisuke Sakai, Min-Hee Ryu, Masahiro Sugihara, Kensei Yamaguchi, Hiroshi Yabusaki, Satoru Iwasa, Takahiro Kamio, Naotoshi Sugimoto, Yung-Jue Bang, Yoshinori Kawaguchi, Kaku Saito
Publikováno v:
New England Journal of Medicine. 382:2419-2430
Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate consisting of an anti-HER2 (human epidermal growth factor receptor 2) antibody, a cleavable tetrapeptide-based linker, and a cytotoxic topoisomerase I inhibitor. The drug may have efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a4ef70fcc265e12aac9a6282d216c1
https://doi.org/10.1056/nejmoa2004413
https://doi.org/10.1056/nejmoa2004413
Autor:
Kunika Kikumori, Tetsu Shinkai, Shunji Takahashi, Akihiko Shimomura, Takahiro Kamio, Ryo Nakamura, Eriko Tokunaga, Toshimi Takano, Junichiro Watanabe, Yasuaki Sagara, Toshinari Yamashita, Emi Kamiyama
Publikováno v:
Cancer Research. 80:P1-18
Background [Fam-] trastuzumab deruxtecan (T-DXd; formerly DS-8201a) is a novel antibody-drug conjugate with a humanized anti-HER2 antibody, peptide-based cleavable linker, and topoisomerase I inhibitor payload (MAAA-1181a). T-DXd has a drug-to-antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4792a68b147c5c99c2b4b4bb752ca6c6
https://doi.org/10.1158/1538-7445.sabcs19-p1-18-12
https://doi.org/10.1158/1538-7445.sabcs19-p1-18-12
Autor:
Akihiko, Shimomura, Toshimi, Takano, Shunji, Takahashi, Yasuaki, Sagara, Junichiro, Watanabe, Eriko, Tokunaga, Tetsu, Shinkai, Takahiro, Kamio, Kunika, Kikumori, Emi, Kamiyama, Yoshihiko, Fujisaki, Dan, Saotome, Toshinari, Yamashita
Publikováno v:
Clinical pharmacology and therapeutics.
HER2-targeted anticancer therapies may be associated with cardiovascular adverse events. This study evaluated effects of the HER2-targeted antibody-drug conjugate trastuzumab deruxtecan (T-DXd, DS-8201a) on QT/QTc interval and its pharmacokinetics. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a042b1746966a3986c0661c306618161
https://pubmed.ncbi.nlm.nih.gov/36164935
https://pubmed.ncbi.nlm.nih.gov/36164935
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 156(1)
Antibody-drug conjugates (ADCs) combine the specific antibody and cytotoxic agent by a linker and represent a promising drug class with a wider therapeutic window than conventional chemotherapeutic agents by substantiating efficient and specific drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b704450798c26a76f6df12b41e5c922a
https://pubmed.ncbi.nlm.nih.gov/33390481
https://pubmed.ncbi.nlm.nih.gov/33390481
Publikováno v:
Internal Medicine
Constrictive pericarditis (CP) is defined as impedance to diastolic filling caused by a fibrotic pericardium. The diagnosis of CP is a clinical challenge and requires a high index of clinical suspicion. The signs and symptoms of CP include fatigue, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb43142afa7368b421cdd95a6c84e05e
https://doi.org/10.2169/internalmedicine.9455-17
https://doi.org/10.2169/internalmedicine.9455-17
Autor:
L. Shen, Yoshinori Kawaguchi, K. Shitara, J. Tabernero, J. Seraj, Takahiro Kamio, G. Meinhardt, F.A. Franke
Publikováno v:
Annals of Oncology. 32:S1073
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4f219ebd414f976f47b21c10830c1ea
https://doi.org/10.1016/j.annonc.2021.08.1545
https://doi.org/10.1016/j.annonc.2021.08.1545
Autor:
Y.-J. Bang, Yoshinori Kawaguchi, Kaku Saito, Hisato Kawakami, J.W. Lee, Satoru Iwasa, Akihito Kojima, K. Shitara, D. Sakai, Naotoshi Sugimoto, Takahiro Kamio, Masahiro Sugihara, H.C. Chung, Hiroshi Yabusaki, M-H. Ryu, Kensei Yamaguchi
Publikováno v:
Annals of Oncology. 31:S899-S900
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1956d4c1f91e1722865700305331979
https://doi.org/10.1016/j.annonc.2020.08.1928
https://doi.org/10.1016/j.annonc.2020.08.1928