Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Takahiro, Kageyama"'
Autor:
Hiroki Furuya, Yosuke Toda, Arifumi Iwata, Mizuki Kanai, Kodai Kato, Takashi Kumagai, Takahiro Kageyama, Shigeru Tanaka, Lisa Fujimura, Akemi Sakamoto, Masahiko Hatano, Akira Suto, Kotaro Suzuki, Hiroshi Nakajima
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Group 2 innate lymphoid cells (ILC2s) are a subset of innate lymphocytes that produce type 2 cytokines, including IL-4, IL-5, and IL-13. GATA3 is a critical transcription factor for ILC2 development at multiple stages. However, when and how
Externí odkaz:
https://doaj.org/article/3fec2ca675de442c8b849b3249ecc28f
Autor:
Kensuke Suga, Masahiro Kiuchi, Takahiro Kageyama, Kota Kokubo, Shigeru Tanaka, Arifumi Iwata, Kotaro Suzuki, Kiyoshi Hirahara, Hiroshi Nakajima
Publikováno v:
Allergology International, Vol 72, Iss 4, Pp 610-613 (2023)
Externí odkaz:
https://doaj.org/article/d7189a4a0bb74ce1a2d8acee44979022
Autor:
Kazuki Hashimoto, Takuma Nakamura, Takahiro Kageyama, Venkata Ramaiah Badarla, Hiroyuki Shimada, Ryoich Horisaki, Takuro Ideguchi
Publikováno v:
Light: Science & Applications, Vol 12, Iss 1, Pp 1-10 (2023)
We develop upconversion time-stretch infrared spectroscopy, which enables high-speed and high-resolution broadband mid-infrared spectroscopy with over 1000 spectral elements at a rate of more than 10 MSpectra s−1.
Externí odkaz:
https://doaj.org/article/acf343483f9a420091cbeee99f819609
Loss of SLC26A3 Results in Colonic Mucosal Immune Dysregulation via Epithelial-Immune Cell Crosstalk
Autor:
Dulari Jayawardena, Shubha Priyamvada, Takahiro Kageyama, Zachary White, Anoop Kumar, Theodor F. Griggs, Apurba Majumder, Ramsha Akram, Arivarasu N. Anbazhagan, Teruyuki Sano, Pradeep K. Dudeja
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 4, Pp 903-919 (2023)
Background & Aims: Down-regulation of chloride transporter SLC26A3 or down-regulated in adenoma (DRA) in colonocytes has recently been linked to the pathogenesis of ulcerative colitis (UC). Because exaggerated immune responses are one of the hallmark
Externí odkaz:
https://doaj.org/article/fd0b8fc91d7c4c7fa67e4275254f6641
Autor:
Tadamichi Kasuya, Shigeru Tanaka, Jun Tamura, Keishi Etori, Jumpei Shoda, Koto Hattori, Yusuke Endo, Masayuki Kitajima, Takahiro Kageyama, Taro Iwamoto, Masaya Yokota, Arifumi Iwata, Akira Suto, Kotaro Suzuki, Harumi Suzuki, Steven F. Ziegler, Hiroshi Nakajima
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Epithelial cells control a variety of immune cells by secreting cytokines to maintain tissue homeostasis on mucosal surfaces. Regulatory T (Treg) cells are essential for immune homeostasis and for preventing tissue inflammation; however, the
Externí odkaz:
https://doaj.org/article/e0fac211478b4b9593b3587845ada559
Autor:
Shunjiro Kurihara, Kotaro Suzuki, Masaya Yokota, Takashi Ito, Yuki Hayashi, Ryo Kikuchi, Takahiro Kageyama, Kazuyuki Meguro, Shigeru Tanaka, Arifumi Iwata, Yoshiyuki Goto, Akira Suto, Hiroshi Nakajima
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 89 (2024)
Oral tolerance has been defined as the specific suppression of immune responses to an antigen by prior oral administration of the antigen. It has been thought to serve to suppress food allergy. Previous studies have shown that dendritic cells (DCs) a
Externí odkaz:
https://doaj.org/article/747ebf2429da4c209d3d5affeb88b9e5
Autor:
Junichi Ishikawa, Akira Suto, Kazuya Abe, Yuki Hayashi, Kensuke Suga, Shigeru Tanaka, Takahiro Kageyama, Arifumi Iwata, Kazumasa Suzuki, Kotaro Suzuki, Hiroshi Nakajima
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Murine IL-17-producing γδT (γδT17) cells are divided into two subsets: natural γδT17 (nγδT17) cells, whose development is restricted to the fetal thymus, and inducible γδT17 cells, which require antigen exposure for their IL-17 production a
Externí odkaz:
https://doaj.org/article/be612ac5726d4828932f1db07fd8318c
Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1
Autor:
Nozomi Nishimura, Masaya Yokota, Shunjiro Kurihara, Arifumi Iwata, Takahiro Kageyama, Takashi Ito, Aiko Saku, Yuko Maezawa, Koichi Hirose, Hiroshi Nakajima
Publikováno v:
Allergology International, Vol 71, Iss 4, Pp 520-527 (2022)
Background: Airway epithelial cells (AECs) play a crucial role in the induction and development of allergic inflammation through the development and activation of immune cells, including Th2 cells and ILC2s. Recent studies have revealed that STAT3 ex
Externí odkaz:
https://doaj.org/article/39768381b74d45f98cf8788bfb27d962
Autor:
Kensuke Suga, Akira Suto, Shigeru Tanaka, Yutaka Sugawara, Takahiro Kageyama, Junichi Ishikawa, Yoshie Sanayama, Kei Ikeda, Shunsuke Furuta, Shin-Ichiro Kagami, Arifumi Iwata, Koichi Hirose, Kotaro Suzuki, Osamu Ohara, Hiroshi Nakajima
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Methotrexate (MTX) is a standard, first-line therapy for rheumatoid arthritis (RA); however, its precise mechanisms of action other than antifolate activity are largely unknown. We performed DNA microarray analyses of CD4+ T cells in patients with RA
Externí odkaz:
https://doaj.org/article/8f9f04e72ce6453796321fc070a9ae6d
Autor:
Shigeru Tanaka, Keishi Etori, Koto Hattori, Jun Tamura, Kei Ikeda, Takahiro Kageyama, Kazuyuki Meguro, Taro Iwamoto, Arifumi Iwata, Shunsuke Furuta, Akira Suto, Kotaro Suzuki, Hiroshi Nakajima
Publikováno v:
Modern Rheumatology; Jul2024, Vol. 34 Issue 4, p700-704, 5p