Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Takahiko Yasuda"'
Autor:
Chiharu Yamada, Kentaro Okada, Koya Odaira, Mahiru Tokoro, Eisuke Iwamoto, Masashi Sanada, Mina Noura, Syuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa
Publikováno v:
Cancer Medicine, Vol 13, Iss 14, Pp n/a-n/a (2024)
Abstract Background ZNF384‐fusion (Z‐fusion) genes were recently identified in B‐cell acute lymphoblastic leukemia (B‐ALL) and are frequent in Japanese adult patients. The frequency is about 20% in those with Philadelphia chromosome‐negativ
Externí odkaz:
https://doaj.org/article/b55bd970f1ed4ff483e308ce00e8478f
Autor:
Mina Noura, Sakura Tomita, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa
Publikováno v:
Cancer Medicine, Vol 13, Iss 13, Pp n/a-n/a (2024)
Abstract Introduction Nucleoporin 98 (NUP98) fusion proteins are recurrently found in leukemia and are associated with unfavorable clinical outcomes. They are distributed to the nucleus and contribute to leukemogenesis via aberrant transcriptional re
Externí odkaz:
https://doaj.org/article/62eef3402d8c4ee5810cff35ce56134f
Autor:
Azusa Mayumi, Toshihiko Imamura, Hideki Yoshida, Shinya Osone, Takahiko Yasuda, Tomoko Iehara
Publikováno v:
eJHaem, Vol 4, Iss 3, Pp 751-755 (2023)
Abstract ETV6::Fyn‐related kinase (FRK), which is a Src family tyrosine‐kinase‐related fusion gene and firstly identified in our patient with paediatric high risk B cell precursor acute lymphoblastic leukaemia (B‐ALL), has no evidence of effi
Externí odkaz:
https://doaj.org/article/c7907b00617548f2ab519662195a4829
Autor:
Shinobu Tsuzuki, Takahiko Yasuda, Hiroaki Goto, Naoko Maeda, Koshi Akahane, Takeshi Inukai, Hideyuki Yamamoto, Sivasundaram Karnan, Akinobu Ota, Toshinori Hyodo, Hiroyuki Konishi, Yoshitaka Hosokawa, Hitoshi Kiyoi, Fumihiko Hayakawa
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is an intractable disease and most cases harbor genetic alterations that activate JAK or ABL signaling. The commonest subtype of Ph-like ALL exhibits a CRLF2 gene rearrangement t
Externí odkaz:
https://doaj.org/article/514652542c624b93836c399d9da87c53
Autor:
Naoyuki Tange, Fumihiko Hayakawa, Takahiko Yasuda, Koya Odaira, Hideyuki Yamamoto, Daiki Hirano, Toshiyasu Sakai, Seitaro Terakura, Shinobu Tsuzuki, Hitoshi Kiyoi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 128, Iss , Pp 110330- (2020)
MEF2D-fusion (M-fusion) genes are newly discovered recurrent gene abnormalities that are detected in approximately 5 % of acute lymphoblastic leukemia (ALL) cases. Their introduction to cells has been reported to transform cell lines or increase the
Externí odkaz:
https://doaj.org/article/63e254a40fcc4088962ec117b8ca8050
Autor:
Yosuke Tanaka, Masahito Kawazu, Takahiko Yasuda, Miki Tamura, Fumihiko Hayakawa, Shinya Kojima, Toshihide Ueno, Hitoshi Kiyoi, Tomoki Naoe, Hiroyuki Mano
Publikováno v:
Haematologica, Vol 103, Iss 11 (2018)
Externí odkaz:
https://doaj.org/article/4e202f4747bf4d419a9feb1e21408a92
Autor:
Masahito Kawazu, Shinya Kojima, Toshihide Ueno, Yasushi Totoki, Hiromi Nakamura, Akiko Kunita, Wei Qu, Jun Yoshimura, Manabu Soda, Takahiko Yasuda, Natsuko Hama, Mihoko Saito-Adachi, Kazuhito Sato, Shinji Kohsaka, Eirin Sai, Masako Ikemura, Shigeru Yamamoto, Tomoko Ogawa, Masashi Fukayama, Keiichiro Tada, Yasuyuki Seto, Shinichi Morishita, Shoichi Hazama, Tatsuhiro Shibata, Yoshihiro Yamashita, Hiroyuki Mano
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006853 (2017)
Triple-negative breast cancer (TNBC) cells do not express estrogen receptors, progesterone receptors, or human epidermal growth factor receptor 2. Currently, apart from poly ADP-ribose polymerase inhibitors, there are few effective therapeutic option
Externí odkaz:
https://doaj.org/article/6a162a70df7847e08883bac287297886
Publikováno v:
Cancer Science. 114:8-15
B-cell acute lymphoblastic leukemia (B-ALL), a genetically heterogeneous disease, is classified into different molecular subtypes that are defined by recurrent gene rearrangements, gross chromosomal abnormalities, or specific gene mutations. Cells wi
Autor:
Yukino Kojima, Fumika Kawashima, Takahiko Yasuda, Koya Odaira, Yuichiro Inagaki, Chiharu Yamada, Ami Muraki, Mina Noura, Shuichi Okamoto, Shogo Tamura, Eisuke Iwamoto, Masashi Sanada, Itaru Matsumura, Yasushi Miyazaki, Tetsuhito Kojima, Hitoshi Kiyoi, Shinobu Tsuzuki, Fumihiko Hayakawa
Publikováno v:
International Journal of Hematology.
Autor:
Fumihiko Hayakawa, Hiroyuki Mano, Yoshitaka Hosokawa, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki, Yoshiyuki Takahashi, Hideki Muramatsu, Kyogo Suzuki, Akihiro Tomita, Keizo Horibe, Hirokazu Nagai, Masashi Sanada, Hiroyuki Konishi, Toshinori Hyodo, Akinobu Ota, Sivasundaram Karnan, Toshihide Ueno, Koichi Miyamura, Takanobu Morishita, Masue Imaizumi, Takeshi Inukai, Koshi Akahane, Masahito Kawazu, Shinya Kojima, Takahiko Yasuda, Shinobu Tsuzuki
The cellular context that integrates gene expression, signaling, and metabolism dictates the oncogenic behavior and shapes the treatment responses in distinct cancer types. Although chimeric fusion proteins involving transcription factors (TF) are ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fd0490528512bf978671cf27c80664
https://doi.org/10.1158/2643-3230.c.6549877
https://doi.org/10.1158/2643-3230.c.6549877