Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Takahiko Hada"'
Publikováno v:
Experimental and Therapeutic Medicine
Previously, we observed that purified monogalactosyl diacylglycerol (MGDG), a major glycoglycerolipid from spinach, selectively inhibits the activities of mammalian replicative DNA polymerases (α, δ and ε). However, the function of MGDG following
Publikováno v:
Oncology Reports. 28:821-828
The glycoglycerolipid monogalactosyl diacylglycerol (MGDG) isolated from spinach selectively inhibits the activities of replicative DNA polymerase species and suppresses the growth of human cancer cell lines, while not affecting normal human cells. L
Autor:
Tomoko Hosokawa, Teruyuki Kanada, Rina Kato, Toshiko Suzuki-Yamamoto, Hiromi Yamashita, Miyuki Yokoro, Shioka Irino, Hideaki Tsuji, Takahiko Hada, Shiori Hirano, Yuki Kawakami, Shinobu Doi, Hirokazu Kobayashi, Chikao Yutani, Yoshitaka Takahashi, Akiko Yoshioka, Tomoko Morinaka, Hiroyuki Itabe, Masumi Kimoto
Publikováno v:
Food Chemistry. 131:1069-1075
Oxidative modification of low density lipoprotein (LDL) is one of the critical steps for the development of atherosclerosis and leucocyte-type 12-lipoxygenase, highly expressed in macrophages, has been suggested to play an essential role in this proc
Autor:
Minako Sato, Hisami Yamanaka-Okumura, Tomoko Baba, Asuka Shiota, Yutaka Taketani, Hironori Yamamoto, Takahiko Hada, Eiji Takeda
Publikováno v:
The Journal of Medical Investigation. 57:314-320
Glycoglycerolipids are mostly found in plants, however the beneficial effects of the glycoglycerolipids on mammalian body have not been understood. In this study, we investigated the effects of glycolipid extracts from spinach, which highly contained
Autor:
Shoji Fukushima, Keisuke Uryu, Takahiko Hada, Kazuro Sugimura, Hiromi Yoshida, Yoshiyuki Mizushina, Yoko Suzuki, Yuko Kumamoto-Yonezawa, Yosuke Ota, Ryohei Sasaki
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1790:339-346
Background Conjugated eicosapentaenoic acid (cEPA) containing conjugated double bonds, which is prepared by alkaline treatment of eicosapentaenoic acid (EPA), selectively inhibited the activities of both mammalian DNA polymerases (pols) and human DNA
Publikováno v:
Food Chemistry. 112:205-210
The glycoglycerolipid fraction from spinach was purified, and this fraction was used to clarify bioactive functions, such as inhibition of DNA polymerase activity and cancer cell growth. The effects of the spinach glycoglycerolipid fraction on preven
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 71:84-90
Antithrombotic activities of odorless garlic powder were demonstrated in blood fibrinolytic and coagulation systems. Though the odorless garlic preparation did not influence tissue-type plasminogen activator (t-PA) or its inhibitor secretions from hu
Autor:
Fumio Sugawara, Yoshiyuki Mizushina, Susumu Kobayashi, Hiromi Yoshida, Hiroaki Shimada, Kouji Kuramochi, Hiroshi Iijima, Takahiko Hada, Masayuki Nishida, Tomoyuki Furukawa
Publikováno v:
Journal of Oleo Science. 56:43-47
We isolated the glycolipids fraction from spinach (Spinacia oleracea L.) and found that the fraction inhibited the activities of prokaryotic DNA polymerase I from Escherichia coli (E. coli) and cell growth of E. coli. The fraction contained mainly th
Autor:
Yoshiyuki Mizushina, Hideki Yoshida, Toru Kuyama, Yuko Yonezawa, Hiromi Yoshida, Takahiko Hada
Publikováno v:
Nippon Eiyo Shokuryo Gakkaishi. 59:271-276
抗がん機能性食品素材の開発を目指して, 天然材料からDNA合成酵素 (DNAポリメラーゼ) 阻害物質を探索したところ, 乾燥グァバ葉の50%エタノール抽出物「グァバ葉(1)」に強い活性を見出し
Publikováno v:
Nippon Eiyo Shokuryo Gakkaishi. 59:15-19
卵黄タンパク質を酵素分解しACEを阻害する加水分解物を得た。卵黄タンパク質の分解は4種類のプロテアーゼ (ビオプラーゼSP-15FG, デナプシン, デナチームAP, パパイン) を用いて検討した