Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Takahide NOMURA"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 1, Pp 17-24 (2010)
5R-l-Erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase (TH). Recently, a type of dopa-responsive dystonia (DRD) (DYT5, Segawa’s disease) was revealed to be caused by dominant mutations of the gene encoding
Externí odkaz:
https://doaj.org/article/6cf2608cf0b942ae9b155bb012d06549
Autor:
Hiroaki Shiraishi, Taiya Kato, Koji Atsuta, Chiho Sumi-Ichinose, Masatsugu Ohtsuki, Mitsuyasu Itoh, Hitoshi Hishida, Shin Tada, Yasuhiro Udagawa, Toshiharu Nagatsu, Yasumichi Hagino, Hiroshi Ichinose, Takahide Nomura
Publikováno v:
Journal of Pharmacological Sciences, Vol 93, Iss 3, Pp 265-271 (2003)
ABSTRACT: Tetrahydrobiopterin (BH4) acts as an essential cofactor for the enzymatic activity of nitric oxide (NO) synthases. Biosynthesis of the cofactor BH4 starts from GTP and requires 3 enzymatic steps, which include GTP cyclohydrolase I (GCH I) c
Externí odkaz:
https://doaj.org/article/65a0a2ec34a74d11950d7056fb8babfb
Autor:
Masatsugu Ohtsuki, Shin Tada, Yasuhiro Udagawa, Kazunao Kondo, Kazuhisa Ikemoto, Hiroaki Shiraishi, Chiho Sumi-Ichinose, Takahide Nomura
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 18:312-317
Aims: Cilostazol, a type III phosphodiesterase inhibitor, is utilized for the treatment of intermittent claudication and is considered to have the beneficial effects against the atherogenic process. In the present study, we examined the effects of ci
Autor:
Setsuko Katoh, Daigo Homma, Hirofumi Tokuoka, Kazuhisa Ikemoto, Kazunao Kondo, Hiroshi Ichinose, Chiho Sumi-Ichinose, Takahide Nomura
Publikováno v:
J Biol Chem. 286:1445-1452
Postnatal development of dopaminergic system is closely related to the development of psychomotor function. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of dopamine and requires tetrahydrobiopterin (BH4) as a cofactor. To
Autor:
Yasumichi Hagino, Risa Kuroda, Masayo Kojima, Masahiro Tazawa, Hiroaki Shiraishi, Toshiharu Nagatsu, Fumi Urano, Chiho Sumi-Ichinose, Takahide Nomura, Hiroshi Ichinose, Tamae Ohye
Publikováno v:
Journal of Biological Chemistry. 276:41150-41160
(6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase (TH), tryptophan hydroxylase, phenylalanine hydroxylase, and nitric-oxide synthase. These enzymes synthesize neurotransmitters, e.g. catecholamines, se
Autor:
Masatsugu Ohtsuki, Yasumichi Hagino, Takahide Nomura, Masahiro Tazawa, Risa Kuroda, Shigeru Matsui, Hiroko Nomura, Hiroaki Shiraishi, Chiho Sumi-Ichinose
Publikováno v:
Pharmacology & Toxicology. 87:246-248
Autor:
Yasumichi Hagino, Takahide Nomura, Shigeru Matsui, Chiho Sumi-Ichinose, Hiroko Nomura, Masatsugu Ohtsuki
Publikováno v:
Pharmacology & Toxicology. 82:40-46
Studies were conducted to clarify the effects of nitric oxide donors NOR 3 ((±)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide, FK409), SIN-1 (3-morpholinosydnonimine) and SNAP (S-nitroso-N-acetylpenicillamine) on the accumulation of cGMP and
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 68
Tetrahydrobiopterin (BH4) is essential for the biosynthesis of dopamine, noradrenaline, and serotonin, which serve as cofactors for tyrosine hydroxylase (TH) and tryptophan hydroxylase. GTP cyclohydrolase (GCH) is the first and rate-limiting enzyme f
Tetrahydrobiopterin (BH4) is essential for the biosynthesis of dopamine, noradrenaline, and serotonin, which serve as cofactors for tyrosine hydroxylase (TH) and tryptophan hydroxylase. GTP cyclohydrolase (GCH) is the first and rate-limiting enzyme f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::996a63298d50f718f782129c9d434809
https://doi.org/10.1016/b978-0-12-411512-5.00003-8
https://doi.org/10.1016/b978-0-12-411512-5.00003-8
Autor:
Masayo Kojima, Yoshinori Aso, Hirofumi Tokuoka, Takahide Nomura, Daniel Metzger, Shin-ichi Muramatsu, Hiroshi Ichinose, Hiroaki Sakane, Chiho Sumi-Ichinose
The tyrosine hydroxylase (TH; EC 1.14.16.2) is a rate-limiting enzyme in the dopamine synthesis and important for the central dopaminergic system, which controls voluntary movements and reward-dependent behaviors. Here, to further explore the regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2142f47b424edb1ae909b884f8cc5bcb
https://europepmc.org/articles/PMC3234829/
https://europepmc.org/articles/PMC3234829/