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Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase.

Autor: Takahata T; Department of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Takeda E; Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Tobiume M; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan., Tokunaga K; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan., Yokoyama M; Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan., Huang YL; Department of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Hasegawa A; Department of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Shioda T; Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Sato H; Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan., Kannagi M; Department of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Masuda T; Department of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan tmasu.impt@tmd.ac.jp.

Publikováno v: Journal of virology [J Virol] 2016 Dec 16; Vol. 91 (1). Date of Electronic Publication: 2016 Dec 16 (Print Publication: 2017).