Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Takaharu Okajima"'
Autor:
Kenta Shigemura, Kaori Kuribayashi-Shigetomi, Ryosuke Tanaka, Haruka Yamasaki, Takaharu Okajima
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
As epithelial cells in vitro reach a highly confluent state, the cells often form a microscale dome-like architecture that encloses a fluid-filled lumen. The domes are stabilized by mechanical stress and luminal pressure. However, the mechanical prop
Externí odkaz:
https://doaj.org/article/3c89be2b4d77482f84f555cb7f09bf45
Publikováno v:
Journal of Biomechanical Science and Engineering, Vol 18, Iss 4, Pp 23-00339-23-00339 (2023)
Atomic force microscopy (AFM) has been extensively used to measure the mechanical properties of single cells and tissues with a high force sensitivity. AFM has been established to quantify mechanical differences between cells, e.g., between normal an
Externí odkaz:
https://doaj.org/article/26a6c334e22a4bd692f896a238782f1a
Autor:
Hirofumi Tsuru, Chika Yoshihara, Hidehiro Suginobe, Mizuki Matsumoto, Yoichiro Ishii, Jun Narita, Ryo Ishii, Renjie Wang, Atsuko Ueyama, Kazutoshi Ueda, Masaki Hirose, Kazuhisa Hashimoto, Hiroki Nagano, Ryosuke Tanaka, Takaharu Okajima, Keiichi Ozono, Hidekazu Ishida
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 13 (2023)
Background Dilated cardiomyopathy (DCM) is a major cause of heart failure in children. Despite intensive genetic analyses, pathogenic gene variants have not been identified in most patients with DCM, which suggests that cardiomyocytes are not solely
Externí odkaz:
https://doaj.org/article/e6039d40fe46452c8bcddb63e277baf4
Autor:
Yuki Fujii, Wataru C. Koizumi, Taichi Imai, Megumi Yokobori, Tomohiro Matsuo, Kotaro Oka, Kohji Hotta, Takaharu Okajima
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Fujii et al. investigate the stiffness of cells in ascidian embryos from the fertilised egg to the stage before gastrulation. They find two types of cell stiffening, occurring during cell division and in the interphase, the latter of which is associa
Externí odkaz:
https://doaj.org/article/c9829359129740dc9439b2173216a084
Autor:
Mizuki Matsumoto, Hirofumi Tsuru, Hidehiro Suginobe, Jun Narita, Ryo Ishii, Masaki Hirose, Kazuhisa Hashimoto, Renjie Wang, Chika Yoshihara, Atsuko Ueyama, Ryosuke Tanaka, Keiichi Ozono, Takaharu Okajima, Hidekazu Ishida
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0275296 (2022)
Restrictive cardiomyopathy (RCM) is a rare disease characterized by increased ventricular stiffness and preserved ventricular contraction. Various sarcomere gene variants are known to cause RCM; however, more than a half of patients do not harbor suc
Externí odkaz:
https://doaj.org/article/a09914d7287c4c10bded7af8db472da0
Autor:
Yuki Fujii, Takaharu Okajima
Publikováno v:
AIP Advances, Vol 9, Iss 1, Pp 015028-015028-6 (2019)
We investigated the apparent Young’s modulus, Em, of soft materials with the surface tilt angle, as measured by colloidal probe atomic force microscopy (AFM). The AFM measurements of soft polymer hydrogels and natural unfertilized eggs showed a cle
Externí odkaz:
https://doaj.org/article/d94223a5c19b44dcac86d700df4053c1
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191928 (2018)
The mechanosensitivity of neurons in the central nervous system (CNS) is an interesting issue as regards understanding neuronal development and designing compliant materials as neural interfaces between neurons and external devices for treating CNS i
Externí odkaz:
https://doaj.org/article/da25c72f9b8b4eed9f9c6cd49cea63fc
Autor:
Takaharu Okajima
Publikováno v:
MEMBRANE. 47:269-272
Autor:
Takaharu OKAJIMA
Publikováno v:
Seibutsu Butsuri. 62:159-164
Autor:
Jun Narita, Hidehiro Suginobe, Mizuki Matsumoto, Hirofumi Tsuru, Takaharu Okajima, Renjie Wang, Ryosuke Tanaka, Shinichi Katsuragi, Ryo Ishii, Nao Tatsumi, Shigetoyo Kogaki, Keiichi Ozono, Hidekazu Ishida
Publikováno v:
Cardiology Research
Background: Idiopathic pulmonary arterial hypertension (IPAH) is a progressive disease caused by vascular remodeling of the pulmonary arteries with elevated pulmonary vascular resistance. Recently, various pulmonary vasodilator drugs have become avai