Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Takaharu Mori"'
Autor:
Mai Ikei, Ryoji Miyazaki, Keigo Monden, Yusuke Naito, Azusa Takeuchi, Yutaro S Takahashi, Yoshiki Tanaka, Keina Murata, Takaharu Mori, Muneyoshi Ichikawa, Tomoya Tsukazaki
Publikováno v:
PLoS Biology, Vol 22, Iss 4, p e3002601 (2024)
Uptake of thiosulfate ions as an inorganic sulfur source from the environment is important for bacterial sulfur assimilation. Recently, a selective thiosulfate uptake pathway involving a membrane protein YeeE (TsuA) in Escherichia coli was characteri
Externí odkaz:
https://doaj.org/article/588485bb6b91481fb95d78913b6549c2
Publikováno v:
eLife, Vol 11 (2022)
Spike (S) protein is the primary antigenic target for neutralization and vaccine development for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It decorates the virus surface and undergoes large motions of its receptor binding doma
Externí odkaz:
https://doaj.org/article/e6d2fba80aa44428895594606307f61d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Structure determination using cryo-electron microscopy (cryo-EM) medium-resolution density maps is often facilitated by flexible fitting. Avoiding overfitting, adjusting force constants driving the structure to the density map, and emulating complex
Externí odkaz:
https://doaj.org/article/2b7b73ca3aa8467b9d9bfe458ceb0680
Autor:
Arata Furukawa, Kunihito Yoshikaie, Takaharu Mori, Hiroyuki Mori, Yusuke V. Morimoto, Yasunori Sugano, Shigehiro Iwaki, Tohru Minamino, Yuji Sugita, Yoshiki Tanaka, Tomoya Tsukazaki
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 895-901 (2017)
Summary: Protein secretion mediated by SecYEG translocon and SecA ATPase is enhanced by membrane-embedded SecDF by using proton motive force. A previous structural study of SecDF indicated that it comprises 12 transmembrane helices that can conduct p
Externí odkaz:
https://doaj.org/article/48061d2fb26046939236aa25cee9ac83
Autor:
Yoshiki Tanaka, Yasunori Sugano, Mizuki Takemoto, Takaharu Mori, Arata Furukawa, Tsukasa Kusakizako, Kaoru Kumazaki, Ayako Kashima, Ryuichiro Ishitani, Yuji Sugita, Osamu Nureki, Tomoya Tsukazaki
Publikováno v:
Cell Reports, Vol 13, Iss 8, Pp 1561-1568 (2015)
The bacterial SecYEG translocon functions as a conserved protein-conducting channel. Conformational transitions of SecYEG allow protein translocation across the membrane without perturbation of membrane permeability. Here, we report the crystal struc
Externí odkaz:
https://doaj.org/article/459a478423c346838346f7051c7065f0
Autor:
Isseki Yu, Takaharu Mori, Tadashi Ando, Ryuhei Harada, Jaewoon Jung, Yuji Sugita, Michael Feig
Publikováno v:
eLife, Vol 5 (2016)
Biological macromolecules function in highly crowded cellular environments. The structure and dynamics of proteins and nucleic acids are well characterized in vitro, but in vivo crowding effects remain unclear. Using molecular dynamics simulations of
Externí odkaz:
https://doaj.org/article/98673b139fe9452fb8fdfd2b5b873997
Publikováno v:
Journal of Chemical Theory and Computation. 17:5312-5321
In recent years, molecular dynamics (MD) simulations with larger time steps have been performed with the hydrogen-mass-repartitioning (HMR) scheme, where the mass of each hydrogen atom is increased to reduce high-frequency motion while the mass of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08eace5263c9a54cb49e02454ba4c502
https://doi.org/10.1021/acs.jctc.1c00185
https://doi.org/10.1021/acs.jctc.1c00185
Publikováno v:
Journal of Chemical Information and Modeling. 61:3516-3528
Structural modeling of proteins from cryo-electron microscopy (cryo-EM) density maps is one of the challenging issues in structural biology. De novo modeling combined with flexible fitting refinement (FFR) has been widely used to build a structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c7365d9ea38166bfa6d65d408e55fd
https://doi.org/10.1021/acs.jcim.1c00230
https://doi.org/10.1021/acs.jcim.1c00230
Elucidation of interactions regulating conformational stability and dynamics of SARS-CoV-2 S-protein
Publikováno v:
Biophysical Journal
The ongoing COVID-19 pandemic caused by the new coronavirus, SARS-CoV-2, calls for urgent developments of vaccines and antiviral drugs. The spike protein of SARS-CoV-2 (S-protein), which consists of trimeric polypeptide chains with glycosylated resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b5582260b796744a7e339f8da41117
https://doi.org/10.1016/j.bpj.2021.01.012
https://doi.org/10.1016/j.bpj.2021.01.012
Publikováno v:
eLife. 11
Spike (S) protein is the primary antigenic target for neutralization and vaccine development for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It decorates the virus surface and undergoes large motions of its receptor binding doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbd6c35a162758e78ca7c13f5539143
https://doi.org/10.7554/elife.75720
https://doi.org/10.7554/elife.75720