Výsledky vyhledávání - "Takaharu Matsuura"

Development of Manufacturing Processes for the Carboxylic Acid Key Intermediate of Lusutrombopag: One-Pot Reaction Process of Formylation and the Horner–Wadsworth–Emmons Reaction

Autor: Makoto Kakinuma, Yutaka Nishino, Yusuke Sato, Tadafumi Komurasaki, Takaharu Matsuura, Yoshiaki Imamura

Publikováno v: Organic Process Research & Development. 24:2651-2656

We describe the development of a one-pot preparation process of (E)-3,5-dichloro-4-(3-ethoxy-2-methyl-3-oxoprop-1-en-1-yl)benzoic acid (3), which is a key carboxylic acid intermediate of lusutrombo...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bf1bbd4fa2e9817f14f6c5362cba805
https://doi.org/10.1021/acs.oprd.0c00311

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Potent Inhibitors of Secretory Phospholipase A2: Synthesis and Inhibitory Activities of Indolizine and Indene Derivatives

Autor: Masahiko Ueno, Takashi Ono, Masaaki Yamada, Toshihiko Okada, Yasushi Murakami, Toshiyuki Kato, Yukiko Chikazawa, Yuji Ito, Mitsuaki Ohtani, Sanji Hagishita, Isao Teshirogi, Takaharu Matsuura, Katsutoshi Yamada, Masaaki Wada, Kazuhiro Shirahase

Publikováno v: Journal of Medicinal Chemistry. 39:3636-3658

Phospholipase A2 is an enzyme which hydrolyzes the sn-2 position of certain cellular phospholipids. The liberated lysophospholipid and arachidonic acid are precursors in the biosynthesis of various biologically active products. As human nonpancreatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8914f7eb81c1a540a3c20589d0fccf93
https://doi.org/10.1021/jm960395q

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ChemInform Abstract: Potent Inhibitors of Secretory Phospholipase A2: Synthesis and Inhibitory Activities of Indolizine and Indene Derivatives

Autor: Isao Teshirogi, Kazuhiro Shirahase, Takashi Ono, Masaaki Yamada, Yuji Ito, Masaaki Wada, Katsutoshi Yamada, Mitsuaki Ohtani, Toshihiko Okada, Yasushi Murakami, Takaharu Matsuura, Sanji Hagishita, Yukiko Chikazawa, Toshiyuki Kato, Masahiko Ueno

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d0f50ea6895d901ec6b1965f8c74230
https://doi.org/10.1002/chin.199703190

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ChemInform Abstract: Highly Effective and Practical Enantioselective Synthesis of Half- Esters of Bicyclo(2.2.1)heptanedicarboxylic Acid

Autor: Masayuki Narisada, Mitsuaki Ohtani, Takaharu Matsuura, Fumihiko Watanabe

Publikováno v: ChemInform. 22

An effective and practical enantioselective synthesis of half-esters of bicyclo [2.2.1] heptane-2,3-dicarboxylic acid was developed by enantioselective fission of σ-symmetrical cyclic anhydrides with chiral mandelic acid derivatives, followed by dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eea150a5eb510e131c63599d2a4586da
https://doi.org/10.1002/chin.199146057

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ChemInform Abstract: Catalytic Asymmetric Synthesis of Either Enantiomer of Physostigmine. Formation of Quaternary Carbon Centers with High Enantioselection by Intramolecular Heck Reactions of (Z)-2-Butenanilides

Autor: Takaharu Matsuura, Daniel J. Poon, Atsuyuki Ashimori, Larry E. Overman

Publikováno v: ChemInform. 25

A practical method for preparing either enantiomer of physostigmine and congeners is reported. The Z stereochemistry of the butenanilide cyclization substrate is required to obtain high enantioselection (95% ee) in the key asymmetric Heck insertion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60a9370e8919b525a84fb4352fd153d4
https://doi.org/10.1002/chin.199416046

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Highly effective and practical enantioselective synthesis of half-esters of bicyclo[2.2.1]heptanedicarboxylic acid

Autor: Fumihiko Watanabe, Takaharu Matsuura, Masayuki Narisada, Mitsuaki Ohtani

Publikováno v: The Journal of Organic Chemistry. 56:4120-4123

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::319f258fa2fe080272da6f8544b17ad9
https://doi.org/10.1021/jo00013a009

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Enantioselective synthesis of S-1452, an orally active potent thromboxane A2 receptor antagonist

Autor: Mitsuaki Ohtani, Fumihiko Watanabe, Takaharu Matsuura, Masayuki Narisada

Publikováno v: The Journal of Organic Chemistry. 56:2122-2127

An efficient and extremely practical enantioselective fission of pro-chiral bicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride was applied to the asymmetric synthesis of the potent and orally active thromboxane A 2 (TXA 2 ) receptor antagonist, S-1452

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01a67ffe90ee18d4a4e024d39a7f4786
https://doi.org/10.1021/jo00006a030

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Synthesis of Metabolites of S-1452, an Orally Active Thromboxane A2 Receptor Antagonist

Autor: Fumihiko Watanabe, Kazuhiro Shirahase, Takaharu Matsuura, Mitsuaki Ohtani

Publikováno v: Chemical and Pharmaceutical Bulletin. 39:2842-2848

The synthesis of 16 metabolites of S-1452, an orally active thromboxane A2 (TXA2) receptor antagonist, is described. Regioselective hydroxylation at C-5 or C-6 of the bicyclo[2.2.1]heptane skeleton of the optically active intermediate 16 was attempte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6f3722531aa548f1d350571a62ab62
https://doi.org/10.1248/cpb.39.2842

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