Zobrazeno 1 - 10
of 491
pro vyhledávání: '"Takafumi Suzuki"'
Autor:
Kunihiro Azuma, Takafumi Suzuki, Kenta Kobayashi, Masako Nagahara, Hirotaka Imai, Akiko Suga, Takeshi Iwata, Tomoyasu Shiraya, Makoto Aihara, Takashi Ueta
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-12 (2024)
Abstract Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, particularly the late-stage of dry AMD known as geographic atrophy (GA), lacks effective treatment options. Genetic mouse models
Externí odkaz:
https://doaj.org/article/bd3beb598eb64000a5b3ab5cb93b582f
Autor:
Miu Sato, Nahoko Yaguchi, Takuya Iijima, Aki Muramatsu, Liam Baird, Takafumi Suzuki, Masayuki Yamamoto
Publikováno v:
Redox Biology, Vol 77, Iss , Pp 103355- (2024)
In the KEAP1-NRF2 stress response system, KEAP1 acts as a sensor for oxidative and electrophilic stresses through formation of S–S bond and C–S bond, respectively. Of the many questions left related to the sensor activity, following three appear
Externí odkaz:
https://doaj.org/article/9153399d75a44ac98cb523fb1b48eb9c
Autor:
Jun Takahashi, Takafumi Suzuki, Miu Sato, Shuji Nitta, Nahoko Yaguchi, Tatsuki Muta, Kouhei Tsuchida, Hiromi Suda, Masanobu Morita, Shin Hamada, Atsushi Masamune, Satoru Takahashi, Takashi Kamei, Masayuki Yamamoto
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114104- (2024)
Summary: Clinical evidence has revealed that high-level activation of NRF2 caused by somatic mutations in NRF2 (NFE2L2) is frequently detected in esophageal squamous cell carcinoma (ESCC), whereas that caused by somatic mutations in KEAP1, a negative
Externí odkaz:
https://doaj.org/article/b9387f5ac24f4c54a7bba4c48792b651
Autor:
Ritsuko Shimizu, Ikuo Hirano, Atsushi Hasegawa, Mikiko Suzuki, Akihito Otsuki, Keiko Taguchi, Fumiki Katsuoka, Akira Uruno, Norio Suzuki, Akane Yumoto, Risa Okada, Masaki Shirakawa, Dai Shiba, Satoru Takahashi, Takafumi Suzuki, Masayuki Yamamoto
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Spaceflight-related stresses impact health via various body systems, including the haematopoietic and immune systems, with effects ranging from moderate alterations of homoeostasis to serious illness. Oxidative stress appears to be involved
Externí odkaz:
https://doaj.org/article/cbdd5e395ae54f96aef12db4171df02b
Autor:
Takafumi Suzuki, Yoshiki Ueta, Naoko Tachi, Yasuhiro Okamoto, Takao Fukutome, Hirofumi Sasajima
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract This study investigated the refractive outcomes of 64 eyes overall including 32 immediate primary phacoemulsification in acute primary angle closure (APAC) eyes and 32 of their fellow eyes. We investigated best-corrected visual acuity, intra
Externí odkaz:
https://doaj.org/article/382a2b19308e47648ef18027e1e037e0
Autor:
Reiji Tanaka, Kei Watanabe, Takafumi Suzuki, Kae Nakamura, Masaharu Yasuda, Hiroshi Ban, Ken-ichi Okada, Shigeru Kitazawa
Publikováno v:
NeuroImage, Vol 285, Iss , Pp 120479- (2024)
Functional magnetic resonance imaging (fMRI) in behaving monkeys has a strong potential to bridge the gap between human neuroimaging and primate neurophysiology. In monkey fMRI, to restrain head movements, researchers usually surgically implant a pla
Externí odkaz:
https://doaj.org/article/98d46bce17304ec8aa9d4440e18342a9
Autor:
Sharadha Dayalan Naidu, Aki Muramatsu, Ryota Saito, Soichiro Asami, Tadashi Honda, Tomonori Hosoya, Ken Itoh, Masayuki Yamamoto, Takafumi Suzuki, Albena T. Dinkova-Kostova
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/5dfbbe1b40ee41239edc4e542ee62be3
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113169- (2023)
Summary: Interaction between the inferotemporal (ITC) and prefrontal (PFC) cortices is critical for retrieving information from memory and maintaining it in working memory. Neural oscillations provide a mechanism for communication between brain regio
Externí odkaz:
https://doaj.org/article/923f2eab1be44a22b572f4a0932e7722
A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells
Autor:
Liam Baird, Keiko Taguchi, Anqi Zhang, Yushi Takahashi, Takafumi Suzuki, Thomas W. Kensler, Masayuki Yamamoto
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102845- (2023)
While it is well established that the KEAP1-NRF2 pathway regulates the main inducible cellular response to oxidative stress, this cytoprotective function of NRF2 could become deleterious to the host if it confers survival onto irreparably damaged cel
Externí odkaz:
https://doaj.org/article/05330e90b7e04718bade953250368fe1
Autor:
Naohisa Miyakawa, Yuji Nagai, Yukiko Hori, Koki Mimura, Asumi Orihara, Kei Oyama, Takeshi Matsuo, Ken-ichi Inoue, Takafumi Suzuki, Toshiyuki Hirabayashi, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Keisuke Kawasaki, Takafumi Minamimoto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Pharmacological and surgical treatments of epilepsy can have unsatisfactory outcomes, so a more targeted and on-demand approach is desirable. Here, the authors demonstrate the usage of inhibitory chemogenetics in male nonhuman primates to attenuate t
Externí odkaz:
https://doaj.org/article/134aeee71b1746ecb0a7efa80a5b5681