Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Takafumi Mukaihira"'
Autor:
Fumihiko Saitoh, Hidemitsu Nishida, Yoshitaka Hosaka, Munetaka Ohkouchi, Naoto Kosuga, Ikuya Shiromizu, Tomokazu Matsusue, Ichiro Yamamoto, Miwa Matsumoto, Takafumi Mukaihira
Publikováno v:
Chemical and Pharmaceutical Bulletin. 55:317-323
In the course of development of factor Xa (FXa) inhibitors, we have found unique compounds containing an N,O- and an N,N-spiro acetal structure. It appeared that the difference in overall conformation due to the N,X-spiro acetal structure might be im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b781fed7c810a4e565ae830ee7f451b
https://doi.org/10.1248/cpb.55.317
https://doi.org/10.1248/cpb.55.317
Publikováno v:
European Journal of Organic Chemistry. 2006:5454-5457
The first asymmetric syntheses of antithrombotic agents M58163 and M58169 are reported. Dynamic kinetic resolution is observed in the amide formation step. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c46daaccf6370556ac2171ba9c6206c
https://doi.org/10.1002/ejoc.200600838
https://doi.org/10.1002/ejoc.200600838
Publikováno v:
Eur. J. Org. Chem.. 2006(No. 10):2269-2272
The first asymmetric synthesis of antithrombotic agent M55529 is reported, wherein the first enantioselective cyclic N,O-acetal formation is clarified. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c5818c882ff5c5e465082473fd5f74
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100617968
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100617968
Autor:
Fumihiko Saitoh, Hidenori Mochizuki, Atsushi Okamoto, Hidemitsu Nishida, Yoshitaka Hosaka, Hiroyasu Shimada, Tomokazu Matsusue, Yutaka Miyazaki, Takafumi Mukaihira, Kazuhiro Suzuki, Masashi Mizuno, Miwa Matsumoto, Shuhei Ohnishi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 52:459-462
Compounds containing an ethylenediamine structure in place of the piperazine ring of M55113 (1) and M55551 (2) were synthesized to investigate the effects of a piperazine moiety and evaluated for activity as factor Xa (FXa) inhibitors. Most such comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96901fe22bd499b167748b2c8c5337a9
https://doi.org/10.1248/cpb.52.459
https://doi.org/10.1248/cpb.52.459
Autor:
Hidemitsu Nishida, Yoshitaka Hosaka, Harada Kousuke, Manabu Itoh, Aki Muraoka, Hidenori Mochizuki, Tomokazu Matsusue, Fumihiko Saitoh, Miwa Matsumoto, Miyuki Fukui, Shuhei Ohnishi, Atsushi Okamoto, Takafumi Mukaihira, Yutaka Miyazaki
Publikováno v:
Chemical and Pharmaceutical Bulletin. 50:1187-1194
Intravascular clot formation is an important event in a number of cardiovascular diseases. The prevention of blood coagulation has become a major target for new therapeutic agents. Factor Xa (FXa) is a trypsin-like serine protease that plays a key ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bc367a4c2a5079d0ff7aa49a511ecc
https://doi.org/10.1248/cpb.50.1187
https://doi.org/10.1248/cpb.50.1187
Publikováno v:
Chemical and Pharmaceutical Bulletin. 42:1784-1790
Chiral syntheses of 3-methyl-5-(phenylthio)-L-histidine (8a) and 3-methyl-5-(1-naphthalenylthio)-L-histidine (8b), selected as models for the asteroid alkaloid imbricatine (7), have been accomplished through a 10-step route starting from 4(5)-bromoim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ec20e245b13a8e8a969e85eaa140a6
https://doi.org/10.1248/cpb.42.1784
https://doi.org/10.1248/cpb.42.1784
Publikováno v:
ChemInform. 26
Chiral syntheses of 3-methyl-5-(phenylthio)-L-histidine (8a) and 3-methyl-5-(1-naphthalenylthio)-L-histidine (8b), selected as models for the asteroid alkaloid imbricatine (7), have been accomplished through a 10-step route starting from 4(5)-bromoim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::904d56d2ff0acd8010c81213f9aafb0f
https://doi.org/10.1002/chin.199518261
https://doi.org/10.1002/chin.199518261
Autor:
Hidemitsu Nishida, Fumihiko Saitoh, Ichiro Yamamoto, Takafumi Mukaihira, Naoto Kosuga, Miwa Matsumoto, Yoshitaka Hosaka, Munetaka Ohkouchi, Ikuya Shiromizu, Tomokazu Matsusue
Publikováno v:
ChemInform. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::118bf4d9c20778f19c72042d8973ee28
https://doi.org/10.1002/chin.200728153
https://doi.org/10.1002/chin.200728153
Autor:
Fumihiko, Saitoh, Hidemitsu, Nishida, Takafumi, Mukaihira, Naoto, Kosuga, Munetaka, Ohkouchi, Tomokazu, Matsusue, Ikuya, Shiromizu, Yoshitaka, Hosaka, Miwa, Matsumoto, Ichiro, Yamamoto
Publikováno v:
Chemicalpharmaceutical bulletin. 55(2)
In the course of development of factor Xa (FXa) inhibitors, we have found unique compounds containing an N,O- and an N,N-spiro acetal structure. It appeared that the difference in overall conformation due to the N,X-spiro acetal structure might be im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2bf426d895bdd7e6b9cd5379bc8fec8
https://pubmed.ncbi.nlm.nih.gov/17268108
https://pubmed.ncbi.nlm.nih.gov/17268108
Publikováno v:
Adv. Synth. Cat.. 349
Dynamic kinetic resolution is one of the most synthetically useful phenomena for asymmetric synthesis. Dynamic kinetic resolution for the catalytic asymmetric synthesis of a spiro[imidazo[1,2-a]pyrazine-2(3H),4′-piperidin]-5(1 H)-one scaffold with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a993fdbf41c1e9ac8ba188758cf92d9
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100630764
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100630764