Zobrazeno 1 - 10
of 315
pro vyhledávání: '"Takafumi Inoue"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Human urine-derived cells (UDCs) are primary cultured cells originating from the upper urinary tract and are known to be multipotent. We previously developed MYOD1-transduced UDCs (MYOD1-UDCs) as a model recapitulating the pathogenesis of Du
Externí odkaz:
https://doaj.org/article/e26f4968a67247378f28053aacbd5fe8
Autor:
Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue, Toshio Ohshima
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-9 (2022)
Abstract Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory. Several lines of conditional Cdk5 knockout mice (KO) ha
Externí odkaz:
https://doaj.org/article/86bfea0428f845fab2f4dccc80274ee4
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Bilaterally projecting CA3 inputs may be crucial for integrating the left and right CA1 during memory but this has not been directly examined. Here, the authors show that projections from bilateral CA3 play a key role in the cross-hemispheric coordin
Externí odkaz:
https://doaj.org/article/94955a31eba443dc84f83d6d0fdafa3a
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105138- (2022)
Summary: Cholesterol, one of the major cell membrane components, stabilizes membrane fluidity and regulates signal transduction. Beside its canonical roles, cholesterol has been reported to directly activate signaling pathways such as hedgehog (Hh).
Externí odkaz:
https://doaj.org/article/403ba8550c034430bd0c98411142823c
Autor:
Haruki Odaka, Tadahiro Numakawa, Minami Soga, Jun Kido, Shiro Matsumoto, Ryutaro Kajihara, Toshika Okumiya, Naoki Tani, Yuki Tanoue, Takaichi Fukuda, Hirokazu Furuya, Takafumi Inoue, Takumi Era
Publikováno v:
Neurobiology of Disease, Vol 152, Iss , Pp 105279- (2021)
Sialidosis is a neuropathic lysosomal storage disease caused by a deficiency in the NEU1 gene-encoding lysosomal neuraminidase and characterized by abnormal accumulation of undigested sialyl-oligoconjugates in systemic organs including brain. Althoug
Externí odkaz:
https://doaj.org/article/d2ee334841064119b1d66c5b560c755b
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-4 (2019)
Abstract Background Pasteurella multocida (P. multocida) forms part of the normal flora of many animals. Although it is a common causative agent of skin and soft tissue infection after an animal bite or scratch, in rare cases it can cause spinal infe
Externí odkaz:
https://doaj.org/article/274808f6156a47fa9588623be887f4be
Autor:
Binglun Li, Mariya Chavarha, Yuho Kobayashi, Satoshi Yoshinaga, Kazunori Nakajima, Michael Z. Lin, Takafumi Inoue
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101363- (2020)
Summary: Recording the electrical activity of multiple neurons simultaneously would greatly facilitate studies on the function of neuronal circuits. The combination of the fast scanning by random-access multiphoton microscopy (RAMP) and the latest tw
Externí odkaz:
https://doaj.org/article/b53475c3277b4908b8b24a3fdaa72e19
Autor:
Takanobu Nakazawa, Ryota Hashimoto, Kazuto Sakoori, Yuki Sugaya, Asami Tanimura, Yuki Hashimotodani, Kazutaka Ohi, Hidenaga Yamamori, Yuka Yasuda, Satomi Umeda-Yano, Yuji Kiyama, Kohtarou Konno, Takeshi Inoue, Kazumasa Yokoyama, Takafumi Inoue, Shusuke Numata, Tohru Ohnuma, Nakao Iwata, Norio Ozaki, Hitoshi Hashimoto, Masahiko Watanabe, Toshiya Manabe, Tadashi Yamamoto, Masatoshi Takeda, Masanobu Kano
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schi
Externí odkaz:
https://doaj.org/article/76c7f59a209646a0ada889e8e6621f22
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1172 (2020)
Schizophrenia is a chronic and disabling psychiatric disorder characterized by disturbances of thought, cognition, and behavior. Despite massive research efforts to date, the etiology and pathophysiology of schizophrenia remain largely unknown. The d
Externí odkaz:
https://doaj.org/article/a12f7b31b0de491d913d58864c0dce7d
Autor:
Xiaohua Jin, Kodai Sasamoto, Jun Nagai, Yuki Yamazaki, Kenta Saito, Yoshio Goshima, Takafumi Inoue, Toshio Ohshima
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate the development and maintenance of dendritic spines is limited. We
Externí odkaz:
https://doaj.org/article/17a7d92474614777a5104ffc65bdb24b