Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Takafumi, Naito"'
Autor:
Takashi Mochizuki, Kaito Shibata, Takafumi Naito, Kumiko Shimoyama, Noriyoshi Ogawa, Masato Maekawa, Junichi Kawakami
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 12, Iss 6, Pp 852-859 (2022)
The quantitation of serum tocilizumab using liquid chromatography tandem-mass spectrometry (LC-MS/MS) method has not been widely applied in clinical settings because of its time-consuming and costly sample pretreatments. The present study aimed to de
Externí odkaz:
https://doaj.org/article/8b7901ed260f47128a86c5891a0ca7bd
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 6, Iss 1, Pp 1-9 (2020)
Abstract Background Itraconazole (ITZ), a triazole antifungal agent, is metabolized to hydroxy-ITZ (OH-ITZ), keto-ITZ (KT-ITZ), and N-desalkyl ITZ (ND-ITZ) by cytochrome P450 3A4. The pharmacokinetics of ND-ITZ remain largely unknown due to the lack
Externí odkaz:
https://doaj.org/article/17fc0c7fe7ab482aadd8ed7a13b41e75
Publikováno v:
Cancer Chemotherapy and Pharmacology. 91:481-490
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd6b52a3ba76a82096ff7525b6e98f37
https://doi.org/10.1007/s00280-023-04537-4
https://doi.org/10.1007/s00280-023-04537-4
Publikováno v:
Journal of Infection and Chemotherapy. 29:119-125
Plasma daptomycin has not been fully characterized in diabetic and obese patients. This study aimed to evaluate the associations of plasma daptomycin with glycation of serum albumin and obesity.Infectious patients (n = 70) receiving intravenous dapto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8d20b0b19cb46dfec5c4ebd1e39c4d
https://doi.org/10.1016/j.jiac.2022.10.002
https://doi.org/10.1016/j.jiac.2022.10.002
Autor:
Shunta Akutsu, Yasuaki Mino, Takafumi Naito, Kohei Hoshikawa, Masao Saotome, Yuichiro Maekawa, Junichi Kawakami
Publikováno v:
European Journal of Clinical Pharmacology. 78:1311-1320
The diuretic effect of tolvaptan is largely blood level-dependent although it does exhibit interindividual differences according to cytochrome P450 (CYP) 3A5 genotype. This study aimed to investigate the pharmacokinetic relationship between plasma to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efcbf4d27f5785c8554bcbc2fcca158
https://doi.org/10.1007/s00228-022-03341-y
https://doi.org/10.1007/s00228-022-03341-y
Autor:
Atsushi Otsuka, Junichi Kawakami, Masato Karayama, Kazuki Abe, Masato Maekawa, Kaito Shibata, Takafumi Naito, Hideaki Miyake, Takafumi Suda
Publikováno v:
European Journal of Clinical Pharmacology. 78:77-87
Serum nivolumab concentrations exhibit a large variation in cancer patients. Cancer cachexia inducing systemic inflammation promotes the elimination of endogenous proteins, while its association with serum nivolumab remains unclear. The present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c57d2ad2d6fd3ae6cdcfd69ddde0ff5
https://doi.org/10.1007/s00228-021-03199-6
https://doi.org/10.1007/s00228-021-03199-6
Publikováno v:
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
Long-term use of itraconazole (ITZ) is associated with a risk of inducing hepatotoxicity. This study aimed to evaluate the associations of plasma concentrations of ITZ and its hydroxylated metabolite (OH-ITZ) with endogenous markers of hepatic functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a142129b1dc9914a938a9bc3b0c4be
https://pubmed.ncbi.nlm.nih.gov/36410672
https://pubmed.ncbi.nlm.nih.gov/36410672
Oral aprepitant has a large interindividual variation in clinical responses in advanced cancer. This study aimed to characterize plasma aprepitant and its N-dealkylated metabolite (ND-AP) based on the cachexia progression and clinical responses in he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6a59a2fa381c2930a90d1189b369ac
https://doi.org/10.21203/rs.3.rs-1959940/v1
https://doi.org/10.21203/rs.3.rs-1959940/v1
Autor:
Kaito Shibata, Junichi Kawakami, Satoshi Hirakawa, Hiroyuki Mineta, Seiji Hosokawa, Koji Suzuki, Takafumi Naito
Publikováno v:
Cancer Chemotherapy and Pharmacology. 87(4):555-565
Purpose: Cetuximab inhibits epidermal growth factor receptor (EGFR) signaling in cancer and skin cells, thereby inducing anti-cancer effects and skin disorders. The present study aimed to evaluate the relationships between serum cetuximab and EGFR-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4dd9da925228c3dfc19eed56e0e6f0
http://hdl.handle.net/10271/00003931
http://hdl.handle.net/10271/00003931
Autor:
Koji Suzuki, Yasuhide Yamada, Takafumi Naito, Kaito Shibata, Kunihiko Itoh, Junichi Kawakami, Hironari Tanaka
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 128:472-481
This study aimed to evaluate the influence of CYP2D6 activity and cachexia progression on the enantiomeric alteration of plasma tramadol and its demethylated metabolites in head and neck cancer patients. Fifty-three head and neck cancer patients rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d639d526ea7cf757922ff623adc7c5a2
https://doi.org/10.1111/bcpt.13528
https://doi.org/10.1111/bcpt.13528